Navigation Links
Estrogen Curbs Appetite: Research

Researchers at Yale School of Medicine have found out that Estrogen regulates the brain's energy metabolism in the same way as the hormone leptin, leading the way to a viable// approach to tackling obesity in people resistant to leptin. Their findings were published in the December 31 online issue of Nature Medicine.

"We found that estrogen suppresses appetite using the same pathways in the brain as the adipose hormone leptin," said lead author Tamas L. Horvath, chair and professor of Comparative Medicine and professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine.

Horvath and his team studied the regulation of obesity in mice with mutations in leptin or estrogen signaling. They analyzed the effect of estrogen on the ability of nerve cells to make new connections in the hypothalamus. They also measured the associated feeding behavior and energy expenditure of the animals.

According to their report, estrogen is a strong regulator of energy metabolism through the brain. They show that while the pathway of estrogen-induced intracellular signaling merges with that of leptin, estrogen's effect on feeding and obesity is independent from leptin or the leptin receptor.

"Impaired estrogen signaling in the brain may be the cause of metabolic changes during menopause," said Horvath. "Brain-selective mimics of estrogen could be a viable approach to tackle obesity in the case of leptin resistance."

In previous studies, Horvath and his team found that that estrogen induces synaptic plasticity in the hypothalamus, so they looked to see whether those alterations by estrogen were in line with the proposed shift in the activity of the hypothalamus.

In future studies, Horvath and his team will analyze brain-specific mimics of estrogen on metabolism, obesity in particular. "Brain-specific estrogen analogs would allow us to take advantage of estradiol's weight reduci ng effects without altering peripheral tissues such as the breast and ovaries," said Horvath.

Source-Eurekalert
SRI
'"/>




Related medicine news :

1. Estrogen lowers cancer risk
2. Estrogen Does Not Prevent Recurrent Strokes
3. Herbs With Estrogen Action Aggravate Cancer Risk
4. Osteoarthritis and Estrogen are connected
5. Estrogen Patch is Safer than Pills for Heart
6. Estrogen in Food Reduces Cancer Risk
7. Estrogen Found To Protect the Colon Against Cancer
8. The Side Effects Of Estrogen Therapy
9. The Effects Of Estrogen Therapy
10. A Likely Use For Estrogen Therapy
11. Preventing Colon Cancer With Estrogen
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/5/2016)... ... May 05, 2016 , ... TLC Laser Eye Centers announced today that it ... center will now be called “Gordon Schanzlin New Vision Institute, a TLC Laser Eye ... full-service facility to ensure that patients continue to receive the highest quality of care. ...
(Date:5/5/2016)... ... May 05, 2016 , ... LELO has discovered many people are ... reach out via email, social media and on the Volonté blog seeking advice about ... I masturbate ‘normal’ or ‘correct’?” , While some methods are more common than others, ...
(Date:5/5/2016)... Collins, CO (PRWEB) , ... May 05, 2016 ... ... announced the commencement of a master charity program created to assist the people ... 60 days, working closely with nonprofit organizations and community leaders. Their hope is ...
(Date:5/5/2016)... Houston, TX (PRWEB) , ... May 05, 2016 , ... ... 2015 AIA/AAH Healthcare Design Awards, presented by the American Institute of Architects and the ... and designed by the renowned Perkins+Will and Harrell Architects, opened to patients in October ...
(Date:5/5/2016)... ARIZ. (PRWEB) , ... May 05, 2016 , ... ... president Jennifer Drago presented a talk highlighting the organization’s successful Care Transitions ... in Chicago. , The talk was titled “Minimizing Costs in the Post-Acute Environment ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... with watching a film or TV show in high definition, you may not be familiar ... Ampronix  is a renowned authorized reseller of the medical industry,s top brands as well as ... ... ... Although initially ...
(Date:5/3/2016)... DUBLIN , May 3, 2016 ... to pay $55 million to a woman who says ... State court awarded Gloria Ristesund $5 million ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ... of accusations against the company. In February, the same ...
(Date:5/3/2016)... JERUSALEM , May 3, 2016 ... (TASE: INTP), a clinical-stage biopharmaceutical company, today announced the ... Clinical and Regulatory Affairs. "Ms. Strauss-Levy has ... affairs, and has established an outstanding track record, having ... development and regulatory approval processes in the ...
Breaking Medicine Technology: