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Estradiol Guards Against Osteoporosis

ere exposed for 24 hours to a drug called etoposide, a cancer chemotherapeutic drug that promotes apoptosis.

Results showed that caspace-3 activity decreased in cells treated with estrogen, but increased in cells not treated with estrogen. "These findings support our hypotheses that the anti-osteoporotic effects of estradiol may result in part from its anti-apoptotic effects on osteoblasts," said Bradford.

"We now are investigating the biochemical mechanisms that mediate the estrogen-dependent inhibition of caspase-3 activity in osteoblasts and whether other pharmacological or nutritional agents might mimic or aid this action of estradiol."

Source-Eurekalert
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