Navigation Links
Estradiol Guards Against Osteoporosis

Researchers find a novel pathway by which estradiol, the primary estrogen in humans maintains bone density. This function is significant as it aids in avoiding osteoporosis. //

It is well known that estrogen is essential for healthy bone, and that when the production of estrogen is reduced, as occurs normally in postmenopausal women and pathogenically after exposure to radiation or chemotherapeutic drugs, bones become brittle and break easily. However, the mechanisms involved aren’t clearly understood.

The new study found that one way estradiol helps to maintain bone density is by stopping the activation of an enzyme known as caspase-3. Also called the executioner caspase, caspase-3 is the central player in initiating the process of apoptosis, or programmed cell death of osteoblasts, the bone cells that aid in the growth and development of new bone and teeth.

Results of the study will be presented tomorrow (Friday, March 23) at the International Association of Dental Research meeting in New Orleans. Peter G. Bradford, Ph.D., senior author on the study said of the results: "Basic and clinical studies have shown that estrogens can prevent both bone loss and reduce the incidence of bone fractures. Our research at the molecular and cellular level suggests that the underlying basis of this protective effect of estrogens involves the prevention of apoptosis in osteoblasts and that the key event in this prevention is the inhibition of caspase-3 activity."

Bradford is an associate professor of pharmacology and toxicology in the UB School of Medicine and Biomedical Sciences and associate professor of oral biology in the UB School of Dental Medicine. Kenneth V. Gerace, a third-year dental student in his laboratory, is first author on the study.

To determine the effect of estradiol on caspase-3 activity, one group of human osteoblasts was treated with estradiol for 24 hours and another group was not. Both groups then w ere exposed for 24 hours to a drug called etoposide, a cancer chemotherapeutic drug that promotes apoptosis.

Results showed that caspace-3 activity decreased in cells treated with estrogen, but increased in cells not treated with estrogen. "These findings support our hypotheses that the anti-osteoporotic effects of estradiol may result in part from its anti-apoptotic effects on osteoblasts," said Bradford.

"We now are investigating the biochemical mechanisms that mediate the estrogen-dependent inhibition of caspase-3 activity in osteoblasts and whether other pharmacological or nutritional agents might mimic or aid this action of estradiol."

Source-Eurekalert
PRI
'"/>




Related medicine news :

1. Delhi Police, Home Guards to Guard LNGP
2. AAI Pharma Files Lawsuit Against Dr. Reddys Laboratories
3. Diabetics Need to Guard Against Nail Fungus
4. New Weapon Against Germs
5. Estrogen Found To Protect the Colon Against Cancer
6. Diet Found To Offer Protection Against Leukemia
7. Olive Oil Found To Offer A Protective Effect Against Breast Cancer
8. WHO Issues Caution Against Bird Flu Epidemic
9. New Supplement Found To Be Effective Against Sunburn
10. Intense Fight Against Polio In India Gets Results
11. Prime Minister Manmohan Against Incentive-Based Population Control
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library ... City Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ... for fumigation is not a common occurrence, but a necessary one in the event that ...
(Date:6/25/2016)... , ... June 25, 2016 , ... ... and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a ... area —Johnson is one of the first doctors to perform the treatment. Orthobiologics ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may ... to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To ... for healthy coping following a traumatic event. , Trauma sufferers tend to feel a ...
(Date:6/24/2016)... ... , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys ... peers for this recognition are considered among the top 2 percent of lawyers practicing ... members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. ...
(Date:6/24/2016)... ... 2016 , ... People across the U.S. are sharpening their pencils and honing ... contest in which patients and their families pay tribute to a genetic counselor by ... Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... N.C. , June 24, 2016  Consumers ... decisions and regulators/payers have placed more emphasis on ... environment, patient support programs in the pharmaceutical industry ... patients, medications. Consequently, pharmaceutical companies are focusing on ... they are providing products and services that improve ...
(Date:6/24/2016)... June 24, 2016  Global Blood Therapeutics, Inc. (GBT) ... developing novel therapeutics for the treatment of grievous ... the closing of its previously announced underwritten public ... the public offering price of $18.75 per share. ... offered by GBT. GBT estimates net proceeds from ...
(Date:6/24/2016)... , June 24, 2016 ... has announced the addition of the " Global ... This report ... provides an updated review, including its applications in various ... total market, which includes three main industries: pharmaceutical and ...
Breaking Medicine Technology: