Navigation Links
Erectile Dysfunction in Diabetes Due to Defect in the NO Mechanisms

events NMDA-induced erection. The researchers hypothesized that the blunted NMDA mediated responses in diabetes reflects an impaired NO mechanism within the PVN. The involvement of an NO mechanism in the NMDA mediated behavioral response was also explored.

Methodology
The rats were exposed to a light/dark cycle, with standard temperature and humidity levels. The animals were randomly selected to receive chemical injection of the streptozotocin (STZ) to induce diabetes. Those rats that did not receive STZ (vehicle injected) served as controls. The experiments began on each of the rats four weeks after the injections.

Four experiments were conducted. Experiment one examined the effect of L-NMMA on NMDA mediated behavioral responses in normal rats; experiment two measured behavioral responses to NMDA or sodium nitroprusside (SNP), an NO donor in both control and diabetic rats; the third experiment observed the effect of diabetes on nNOS protein in the PVN; the fourth experiment measured NMDA mediated behavioral responses in diabetic rats after restoring the nNOS protein in the PVN using viral gene transfer.

Results
The researchers found that:
* When L-NMMA was used to block NO production in the PVN, NMDA mediated penile erectile responses were blunted
* NMDA-induced erections were significantly blunted in diabetic rats compared with control rats
* The nNOS protein levels in the PVN were decreased in rats with diabetes and
* restoring nNOS protein within the PVN of diabetic rats with viral gene transfer could alleviate the blunted NMDA induced erectile responses.

Conclusion
The researchers conclude that erectile dysfunction in diabetes is due to a selective defect in the NO mechanisms within the PVN. This defect is a loss in the synthetic enzyme for the production of NO within the neurons of the PVN. Restoring this synthetic enzyme may have a significa
'"/>




Page: 1 2 3

Related medicine news :

1. Erectile dysfunction (ED) signals vascular disease
2. An Exploration into Erectile Dysfunction in Diabetics
3. Erectile dysfunction: an early warning sign of clinically silent coronary artery disease?
4. Erectile Dysfunction Drug Viagra Launched In India By Pfizer
5. Cardiovascular Disease More Common Among Erectile Dysfunction Patients
6. Erectile Dysfunction Connected To Heart Disease
7. Statins For Erectile Dysfunction- An Alternative To Viagra?
8. Erectile Dysfunction Can Be Rectified By Healthy Way Of Life
9. Host of Benefits from Erectile Dysfunction Drugs
10. Erectile Dysfunction Linked with Smoking and Obesity – Study Report
11. South Africans Turn to Natural Remedies for Treating Erectile Dysfunction
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Erectile Dysfunction Diabetes Due Defect the Mechanisms

(Date:12/25/2014)... 2014 Recently, BellasDress has ... its wedding dresses. BellasDress has chosen their best-selling lace ... choices for the holiday season. , Now, BellasDress.com ... wedding gowns here at discount prices. The business hopes ... its website. , “All our elegant products ...
(Date:12/25/2014)... HealthDay Reporter WEDNESDAY, Dec. 24, 2014 (HealthDay ... receive effective, less expensive care from a clinic that functions ... of dedicated health care professionals, a new study shows. ... either hospitalization or a trip to the emergency room when ... the University of Texas in Houston versus usual care, according ...
(Date:12/25/2014)... 25, 2014 AngelWeddingDress.com tries its best ... online realm. Today, the business has introduced its new ... prom dress promotion. , The new prom outfits are ... every dress lover. They are specially designed for 2015. ... dresses should visit its website before Jan. 26, ...
(Date:12/25/2014)... CA (PRWEB) December 25, 2014 Each ... visits and 2 million hospital admissions across the nation ... Prevention ). The CDC’s National Hospital Ambulatory Medical ... through a survey conducted in 2010. They estimated that ... visits that resulted in a primary diagnosis of broken ...
(Date:12/24/2014)... 24, 2014 Connie Casad, MD, a ... medicine advocate with 30 years of practice experience in ... the health benefits of dietary detoxification. The second study ... following excellent results from test patients who just completed ... explain her interest in conducting the study, Dr. Casad ...
Breaking Medicine News(10 mins):Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Angelweddingdress 2015 Prom Dresses Online Now 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 3Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 4Health News:Connie Casad, MD, Now Accepting Test Participants for January Dietary Detoxification Study 2Health News:Connie Casad, MD, Now Accepting Test Participants for January Dietary Detoxification Study 3
... exercise improves your cholesterol profile, even in the absence ... how exercise affects the level of 'good' and 'bad' ... body attached to protein molecules, the combination being known ... or 'bad' cholesterol) are linked to heart disease, while ...
... person aged 40 or over has a lifetime risk of ... they have high blood pressure. Heart failure is an increasing ... within the heart which makes it hard to pump blood ... the condition is very disabling. ,Researchers for the ...
... gets better if specialists in critical care medicine manage ... have analysed the evidence on managing patients in intensive ... much better if they are cared for by a ... ,Previous research has suggested that the involvement ...
... do not fare as well as men when it comes ... Germany now confirm what has long been suspected - kidneys, ... be rejected// by the recipients than those from males. Female ... ,The study covered more than 114,000 kidney transplants, ...
... and vegetables which increases by one third for every additional ... and content of people's daily diet.//According to a new study ... these is the convenience of shopping facilities. The survey looked ... ,Six times more supermarkets were located in areas ...
... test for bowel cancer based upon a molecule found only ... highly curable if caught early. Screening with sigmoidoscopy - an ... the disease. Now researchers in the find that a reliable ... ,The bowel sheds cells into feces all the time. ...
Cached Medicine News:
(Date:12/24/2014)... TIJUANA, Mexico , Dec. 24, 2014 /PRNewswire/ ... treatment of its first patient in its study ... to the American Stroke Association, ischemic strokes account ... continues to enroll qualified patients in the study, ... Intravenous Administration of Allogeneic Mesenchymal Stem Cells and ...
(Date:12/24/2014)... Dec. 24, 2014 Soligenix, Inc. (OTCQB: ... company developing products that address unmet medical needs ... announced today that on December 24, 2014 it ... The Company raised approximately $2.3 million in ... use the net proceeds from the offering to ...
(Date:12/24/2014)... , December 24, 2014 ... at an average rate of 8.1%. The US has ... knee and spine surgeries are the common orthopedic procedures ... have a lower penetration. Increased number of product recalls ... Non-metallic orthopedic devices have gained popularity in the industry ...
Breaking Medicine Technology:Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 2Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 3Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 4Soligenix Announces Closing of Public Offering of Units 2Soligenix Announces Closing of Public Offering of Units 3Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 2Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 3
... , STAMFORD, Conn. , Feb. ... treatment will soon have advanced technology available to the medical ... FUJIFILM Medical Systems USA (Fujifilm), and AmeriCares, a portable digital ... and will be sent to a hospital where currently x-ray ...
... , , SINGAPORE , UPPSALA, Sweden ... Novus Scientific Pte. Ltd today announced that the US Food and ... the TIGR™ Matrix Surgical Mesh, for use in reinforcement ... Mesh is a 100 percent resorbable, synthetic matrix, knitted from two ...
Cached Medicine Technology:Local Organizations Partner to Improve Healthcare in Haiti 2Local Organizations Partner to Improve Healthcare in Haiti 3Local Organizations Partner to Improve Healthcare in Haiti 4Local Organizations Partner to Improve Healthcare in Haiti 5Novus Scientific Receives FDA Clearance for TIGR(TM) Matrix Surgical Mesh - World's 1st Long-Term Resorbable Synthetic Mesh 2Novus Scientific Receives FDA Clearance for TIGR(TM) Matrix Surgical Mesh - World's 1st Long-Term Resorbable Synthetic Mesh 3
... The Diamedix Immunosimplicity (Is) Rubella IgG ... for the qualitative and quantitative detection ... can be performed either manually or ... EIA Processor. The results are reported ...
... VITROS HBsAg assay is the ... the U.S. Food and Drug,Administration ... a random,access format on the ... Now you can run an,HBsAg ...
... For use as a quality ... immunoglobulin M (IgM) antibodies to ... IgM), IgM antibodies to hepatitis ... B e antigen (HBeAg) and ...
... This SIGNET anti-PSA antibody gives ... all cases of benign hyperplasia. In ... intense staining and 34% give definite ... only a minority of cells; this ...
Medicine Products: