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Enzyme stimulates growth of adult stem cells

According to researchers at the University of Texas, an enzyme has been found, that instigates the growth and maturation of stem cells lurking in bone marrow, causing the stem cells to step up production and replace lost blood and immune system cells.//

It is possible the enzyme may also spur the growth of stem cells elsewhere in the body. This information may help researchers determine how to harness the potential of adult stem cells to treat a variety of ailments. Stem cells are immature cells that give rise to the specialized cells that make up the body, and scientists believe they can be used to repair the damaged tissue that marks diseases like Parkinson's, diabetes and heart disease. In a developing embryo, stem cells are able to mature into all types of tissue.

Such cells have traditionally been thought to be limited in potential--with, for example, gut stem cells giving rise to gut cells and brain stem cells producing only brain cells--although recent research has been challenging that thinking. For instance, transplanted bone marrow stem cells have shown up in mature kidney, liver, skin and gastrointestinal tissue.

A long-standing problem with adult stem cells is that they are relatively rare and secluded in the body, which has severely hampered attempts to investigate their use in treating disease. Dr. Shahin Rafii of Cornell University Medical College in Texas, and his colleagues report that adult stem cells are stimulated to do their job by an enzyme, metalloproteinase-9 (MMP-9). Injury turns on MMP9, Rafii explained, which helps release growth-promoting substances which, in turn, wake up the stem cells. The stem cells then move to a portion of the bone marrow where they can multiply and be released.

Rafii and his team discovered the significance of MMP9 when they examined mice that had been engineered to grow and develop without the enzyme. When the researchers treated the mice with chemotherapy that severely
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