Navigation Links
Environmental Factors Linked to Increased Risk of Breast Cancer

Women can encounter environmental factors that increase their risk of breast cancer at// various periods of their physical development, beginning before birth and extending until menopause. These non-inherited, or epigenetic, changes in DNA can correlate with risk factors for breast cancer, according to research by the American Association for Cancer Research.

To study the effects of epigenetic changes in DNA, a team of researchers from Columbia University School of Public Health, led by Mary Beth B. Terry, Ph.D., collected information from former participants of the National Collaborative Perinatal Project born between 1959 and 1966.

"We’ve been following a birth cohort of women who were all born at Columbia in the late 50s and early 60s," said Terry. "We’re interested to find if early life factors are associated with breast cancer susceptibility."

The researchers gathered data on childhood and adult exposures, along with blood samples and mammograms, from 263 women. Terry and her colleagues looked at an epigenetic effect called DNA methylation, whereby DNA is tagged by a molecular "methyl" fragment, which alters activation of the genes. In this instance, the researchers looked at global hypomethylation – aberrant methylation throughout the entirety of a person’s DNA.

The researchers found differences in global DNA hypomethylation depending on breast cancer risk factors including racial group, smoking status, and infant and childhood size. "Birth size in particular has been correlated with breast cancer later in life, but nobody really knows why," Terry pointed out. "This is a small pilot study to look at one possible mechanism."

Other correlating factors included ethnic group and smoking or nonsmoking status. Twenty-one percent of whites, 39 percent of blacks, and 13 percent of Hispanics were in the highest quartile, while 35 percent current smokers were in the highest quartile compared with 15 pe rcent former smokers and 26 percent of women who never smoked.

The researchers also plan to look at gene-specific hypermethylation in a variety of different genes that might be important for breast cancer, according to Terry.

Terry notes that although this pilot study used a very diverse sample, it was still a relatively small group, and the next step is a much larger study using samples from hundreds of women. Such an effort is currently in progress.

"We’re going to try to see if we find these patterns holding up in a much larger sample now," Terry said. "We see this as a first step to understand why measures from birth might be related to adult disease much later in life."

Source-Eurekalert'"/>




Related medicine news :

1. Environmental Factors Found To Have An Impact On The Sex of A Child
2. Environmental Factors Found To Have An Impact On The Sex of A Child
3. Environmental estrogens can cause breast cancer
4. Athletes Are More Prone To Environmental Pollutants Due To Choice Of Diet
5. Industrial and Environmental pollutants increase diabetes risk
6. Environmental Abuse Causes Health Hazards
7. Genes And Environmental Factors Determine Stress Response
8. Air Pollution in Tamil Nadu is a Cause of Concern for Environmentalists
9. WHO Outlines the Link between Environmental Hazards and Disease
10. Environmental Factors Leads to Obesity in Rural Communities
11. Environmental Factors Trigger Onset of Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/23/2016)... ... May 23, 2016 , ... While new U.S. opioid ... physicians are not legally required to follow them. In the absence of federal ... Novus Medical Detox Center , a leading Florida-based drug treatment facility, strongly ...
(Date:5/23/2016)... ... ... the upcoming airing of Innovations with Ed Begley, Jr., ... 4:00pET via Fox Business. , The show will explore ... safely and rapidly develop cures for mosquito-borne, emerging infectious ...
(Date:5/23/2016)... , ... May 23, 2016 ... ... Size for Verification and Validation:, Tools to Safely Speed Your Device to ... http://www.fdanews.com/bestdevicesamplesizevv                  , Today's FDA inspectors focus like lasers on device ...
(Date:5/23/2016)... (PRWEB) , ... May 23, 2016 , ... ... the action analytics leader as Chief Medical Officer. Dr. O’Connor’s deep expertise in ... product development and client services teams who deliver best-in-class solutions and transformative technologies ...
(Date:5/23/2016)... Valley, California (PRWEB) , ... May 23, 2016 ... ... clinical communications and solutions for healthcare providers announced today that AGNITY MobileCare™ Platform ... and health collaboration applications as a part of its M-Health Solution. Tech Mahindra ...
Breaking Medicine News(10 mins):
(Date:5/19/2016)... Israel , May 19, 2016 ... the "Company"), an emerging global ophthalmic company focused on ... candidates which address ophthalmic conditions, announced today that it ... Italy ) for the manufacturing, distribution, marketing ... for the treatment of dry eye syndrome (DES) and ...
(Date:5/19/2016)... May 19, 2016 A ... World Biopsy Devices Market Opportunities and Forecasts, 2014 ... market generated $1,621 million in 2015. The MRI-guided ... and is expected to maintain this trend over ... http://photos.prnewswire.com/prnh/20140911/647229 ) , To know ...
(Date:5/19/2016)... BioLineRx Ltd. (NASDAQ/TASE: BLRX) announced ... of multiple cancer and hematological indications, will be presented ... titled " Clinical response in relapsed/refractory AML patients correlates ... a potent CXCR4 antagonist; results of a Phase 2a ... the European Hematology Association 21st Congress, to be held ...
Breaking Medicine Technology: