Navigation Links
Environmental Factors Linked to Increased Risk of Breast Cancer

Women can encounter environmental factors that increase their risk of breast cancer at// various periods of their physical development, beginning before birth and extending until menopause. These non-inherited, or epigenetic, changes in DNA can correlate with risk factors for breast cancer, according to research by the American Association for Cancer Research.

To study the effects of epigenetic changes in DNA, a team of researchers from Columbia University School of Public Health, led by Mary Beth B. Terry, Ph.D., collected information from former participants of the National Collaborative Perinatal Project born between 1959 and 1966.

"We’ve been following a birth cohort of women who were all born at Columbia in the late 50s and early 60s," said Terry. "We’re interested to find if early life factors are associated with breast cancer susceptibility."

The researchers gathered data on childhood and adult exposures, along with blood samples and mammograms, from 263 women. Terry and her colleagues looked at an epigenetic effect called DNA methylation, whereby DNA is tagged by a molecular "methyl" fragment, which alters activation of the genes. In this instance, the researchers looked at global hypomethylation – aberrant methylation throughout the entirety of a person’s DNA.

The researchers found differences in global DNA hypomethylation depending on breast cancer risk factors including racial group, smoking status, and infant and childhood size. "Birth size in particular has been correlated with breast cancer later in life, but nobody really knows why," Terry pointed out. "This is a small pilot study to look at one possible mechanism."

Other correlating factors included ethnic group and smoking or nonsmoking status. Twenty-one percent of whites, 39 percent of blacks, and 13 percent of Hispanics were in the highest quartile, while 35 percent current smokers were in the highest quartile compared with 15 pe rcent former smokers and 26 percent of women who never smoked.

The researchers also plan to look at gene-specific hypermethylation in a variety of different genes that might be important for breast cancer, according to Terry.

Terry notes that although this pilot study used a very diverse sample, it was still a relatively small group, and the next step is a much larger study using samples from hundreds of women. Such an effort is currently in progress.

"We’re going to try to see if we find these patterns holding up in a much larger sample now," Terry said. "We see this as a first step to understand why measures from birth might be related to adult disease much later in life."

Source-Eurekalert'"/>




Related medicine news :

1. Environmental Factors Found To Have An Impact On The Sex of A Child
2. Environmental Factors Found To Have An Impact On The Sex of A Child
3. Environmental estrogens can cause breast cancer
4. Athletes Are More Prone To Environmental Pollutants Due To Choice Of Diet
5. Industrial and Environmental pollutants increase diabetes risk
6. Environmental Abuse Causes Health Hazards
7. Genes And Environmental Factors Determine Stress Response
8. Air Pollution in Tamil Nadu is a Cause of Concern for Environmentalists
9. WHO Outlines the Link between Environmental Hazards and Disease
10. Environmental Factors Leads to Obesity in Rural Communities
11. Environmental Factors Trigger Onset of Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... , ... While it’s often important to take certain medications during the night, ... has identified a solution. , She developed a prototype for MOTION LIGHT-UP PILL BOX ... eliminates the need to turn on a light when taking medication during the night, ...
(Date:10/13/2017)... ... October 13, 2017 , ... Southern ... and Jennifer Huggins, PharmD ’17, along with clinical associate professor Janice Frueh, ... cardiovascular diseases during the 15th Annual Women’s Health Conference. The SIU School ...
(Date:10/13/2017)... RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... annual Holly Day Market. Featuring a collection of specialty vendors and unique items from ... of personalized and quality-focused health and wellness services offered by the VNA. The ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... giving viewers the lowdown on sciatica in a new episode of "Success Files," ... on current events and innovation and investigates each subject in-depth with passion and ...
(Date:10/12/2017)... WILMINGTON, Del. (PRWEB) , ... October 12, 2017 ... ... technology and advisory services for healthcare compliance program management, will showcase a range ... and National Association for Assisted Living (NCAL) Convention and Expo to be held ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare ... CPR training aide "cprCUBE" on Kickstarter. The device will ... during cardiac arrests with better efficiency compared to the ... offers real-time feedback on efficacy of the compression for ... campaign has a goal to raise $5,000. ...
(Date:10/2/2017)... 2, 2017  Eli Lilly and Company (NYSE: ... the third quarter of 2017 on Tuesday, October 24, ... that day with the investment community and media to ... conference call will begin at 9 a.m. Eastern time. ... live webcast of the conference call through a link ...
(Date:9/28/2017)... Hill-Rom Holdings, Inc. (NYSE: HRC), will host ... webcast on Friday, November 3, 2017, beginning at 7:00 ... approximately 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... performance and guidance for 2018, Hill-Rom executives will also ... performance, and long-range financial outlook through 2020. ...
Breaking Medicine Technology: