Navigation Links
Enriching Environment Stimulates Neurons: Hope For Fragile X Syndrome

A new finding by a team of researchers, led by Huibert Mansvelder reveals that a stimulating environment can restore the malfunctioning neuronal machinery of Fragile X syndrome . The findings have been published in the May 24, 2007 issue of the journal Neuron, published by Cell Press.

A type of inherited mental retardation; Fragile X syndrome affects 1 in 3600 males and 1 in 4000 to 6000 females. The researchers carried out studies on mice that were genetically altered to match the defects in humans with this mental disorder. The scientists performed a detailed analysis of the electrophysiological properties of neurons in the prefrontal cortex, a region responsible for higher cognitive functions, including learning and memory, that are affected in humans with the disorder.

The scientists analysis revealed that the neurons in the mice showed reduction of a particular form of a process called "long-term potentiation" that is central to the formation of new circuit pathways in learning and memory. The researchers experiments showed that this reduction was due to abnormalities in the pore-like channels that regulate the flow of calcium into neurons.

Importantly, they found that increased stimulation of neurons in the mice, which enhanced calcium signaling, could restore normal long-term potentiation and neuronal plasticity.

There have been reports that Fragile X patients can still learn and memorize information but need more repetition and stimulation. Also, studies by other researchers had shown that exposing Fragile X knockout mice to a stimulating environment ameliorated behavioral and neuronal abnormalities.

So, Mansvelder and colleagues tested whether exposure of the knockout mice to an enriched environment caused higher stimulation that would restore normal neuronal plasticity. They gave such mice a variety of cage toys, and also gave them time in play cages that contained running wheels, tunnel s, different bedding material, and interesting objects.

The researchers found that such an enriched environment did, indeed, restore normal neuronal plasticity. The researchers concluded that "increased sensory, cognitive, and motor stimulation by environmental enrichment facilitates the development of synaptic plasticity in cortical areas involved in higher cognitive function. The results of this study demonstrate that in prefrontal cortex of Fragile X knockout mice, excitatory synapses can show lasting increases in synaptic strength, but this requires increased neuronal activity to occur."


'"/>




Related medicine news :

1. GlaxoSmithKline To Cultivate Non-Smoking Environment
2. Alcoholism Influenced By Both Genetics & Family Environment
3. Environment and Diet Found To Precipitate Asthma
4. Environmental Factors Found To Have An Impact On The Sex of A Child
5. Environmental Factors Found To Have An Impact On The Sex of A Child
6. Environmental estrogens can cause breast cancer
7. Athletes Are More Prone To Environmental Pollutants Due To Choice Of Diet
8. Industrial and Environmental pollutants increase diabetes risk
9. Environment a major factor in occurrence of Type 2 Diabetes
10. Environmental Abuse Causes Health Hazards
11. Urban Built Environment May Play a Vital Role in Influencing the Body Size
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/5/2016)... ... February 05, 2016 , ... Freed-Hardeman University President Joe ... signed a joint enrollment and degree completion agreement. The agreement, which begins ... degrees at FHU|Dickson. , The agreement allows students to be jointly admitted ...
(Date:2/5/2016)... ... February 05, 2016 , ... In the fourth ... country gathered at the La Valencia Hotel in San Diego, California to discuss ... named the year’s most outstanding franchise, walking away with the coveted David Wright ...
(Date:2/5/2016)... SARASOTA, Fla., (PRWEB) , ... February 05, 2016 , ... ... appetizing recipes just in time for this weekend’s Big Game. Take the stress out ... ingredients that will keep your guests happy at every stage of the game. , ...
(Date:2/5/2016)... ... February 05, 2016 , ... Stuart Bentkover, MD, FACS is ... to provide the most effective tattoo removal today, Dr. Bentkover is the only doctor ... by Cynosure, the PicoSure has been approved by the Food and Drug Administration (FDA) ...
(Date:2/5/2016)... ... February 05, 2016 , ... Health and wellness is a topic that should ... event they are experiencing an illness. Migraines are a severe form of a headache ... migraines would not wish the pain on their worst enemy, the feeling can last ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... Calif. , Feb. 4, 2016  Edwards Lifesciences ... patient-focused innovations for structural heart disease and critical care ... accelerated share repurchase (ASR) agreement with Morgan Stanley & ... stock.  This repurchase is part of the Company,s previously ... the Company,s common stock.  --> ...
(Date:2/4/2016)... Feb. 4, 2016 Worldwide Radiology Oncology ... growth as next generation systems provide a way ... for cancer surgery. New systems pinpoint the delivery ... has been such a problem previously, limiting the ... robots take cancer surgery far beyond what has ...
(Date:2/4/2016)... Calif. , Feb. 4, 2016  SciClone ... today announced it has entered into a settlement ... Commission (SEC) fully resolving the SEC,s investigation into ... (FCPA).  Under the terms of the settlement agreement, ... $12.8 million, including disgorgement, pre-judgment interest and a ...
Breaking Medicine Technology: