Navigation Links
Enriching Environment Stimulates Neurons: Hope For Fragile X Syndrome

A new finding by a team of researchers, led by Huibert Mansvelder reveals that a stimulating environment can restore the malfunctioning neuronal machinery of Fragile X syndrome . The findings have been published in the May 24, 2007 issue of the journal Neuron, published by Cell Press.

A type of inherited mental retardation; Fragile X syndrome affects 1 in 3600 males and 1 in 4000 to 6000 females. The researchers carried out studies on mice that were genetically altered to match the defects in humans with this mental disorder. The scientists performed a detailed analysis of the electrophysiological properties of neurons in the prefrontal cortex, a region responsible for higher cognitive functions, including learning and memory, that are affected in humans with the disorder.

The scientists analysis revealed that the neurons in the mice showed reduction of a particular form of a process called "long-term potentiation" that is central to the formation of new circuit pathways in learning and memory. The researchers experiments showed that this reduction was due to abnormalities in the pore-like channels that regulate the flow of calcium into neurons.

Importantly, they found that increased stimulation of neurons in the mice, which enhanced calcium signaling, could restore normal long-term potentiation and neuronal plasticity.

There have been reports that Fragile X patients can still learn and memorize information but need more repetition and stimulation. Also, studies by other researchers had shown that exposing Fragile X knockout mice to a stimulating environment ameliorated behavioral and neuronal abnormalities.

So, Mansvelder and colleagues tested whether exposure of the knockout mice to an enriched environment caused higher stimulation that would restore normal neuronal plasticity. They gave such mice a variety of cage toys, and also gave them time in play cages that contained running wheels, tunnel s, different bedding material, and interesting objects.

The researchers found that such an enriched environment did, indeed, restore normal neuronal plasticity. The researchers concluded that "increased sensory, cognitive, and motor stimulation by environmental enrichment facilitates the development of synaptic plasticity in cortical areas involved in higher cognitive function. The results of this study demonstrate that in prefrontal cortex of Fragile X knockout mice, excitatory synapses can show lasting increases in synaptic strength, but this requires increased neuronal activity to occur."


Related medicine news :

1. GlaxoSmithKline To Cultivate Non-Smoking Environment
2. Alcoholism Influenced By Both Genetics & Family Environment
3. Environment and Diet Found To Precipitate Asthma
4. Environmental Factors Found To Have An Impact On The Sex of A Child
5. Environmental Factors Found To Have An Impact On The Sex of A Child
6. Environmental estrogens can cause breast cancer
7. Athletes Are More Prone To Environmental Pollutants Due To Choice Of Diet
8. Industrial and Environmental pollutants increase diabetes risk
9. Environment a major factor in occurrence of Type 2 Diabetes
10. Environmental Abuse Causes Health Hazards
11. Urban Built Environment May Play a Vital Role in Influencing the Body Size
Post Your Comments:

(Date:11/24/2015)... ... November 24, 2015 , ... ... their Black Friday sale a week early, offering 40% off select bras and ... intimate apparel industry through both mobile fit technology and the latest fashion, quickly ...
(Date:11/24/2015)... ... November 24, 2015 , ... DMG Productions announced that they will ... first quarter 2016 via Discovery Channel. Dates and show times TBA. , Aphria, Inc., ... in the business of producing and supplying medical marijuana pursuant to the Marijuana for ...
(Date:11/24/2015)... City, UT (PRWEB) , ... November 24, 2015 , ... ... Forbes Magazine. For a business, it is critical that the first impression be positive ... business, they are not likely to buy anything or want to return. They will ...
(Date:11/24/2015)... Richey, FL (PRWEB) , ... November 24, 2015 , ... ... deems a growing epidemic as deaths from prescription opioids in the United States grew ... and cocaine. In 2013 alone, opioids were involved in 37 percent of all fatal ...
(Date:11/24/2015)... ALEXANDRIA, VA (PRWEB) , ... November 24, 2015 ... ... encourages people across the United States to support their local poison centers through ... been designated as #GivingTuesday: calls it “a day that inspires people to ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... -- The uptake of recently approved and pipeline premium products ... market growth to 2021, says GBI Research . ... for Type 1 Diabetes Mellitus (T1DM), will be a key driver of ... --> The uptake of recently approved and pipeline premium ... of market growth to 2021, says GBI Research ...
(Date:11/24/2015)... 24, 2015   Renowned ... deliver s advice and insights on ... More than 50% of Dubai ... according to the DHA   femMED launches comprehensive solutions for ... Dubai residents are not consuming enough to keep ...
(Date:11/24/2015)...  Freudenberg Medical has developed specialty tubing for an inexpensive, ... facilities. Africa and ... Nevertheless, prompt diagnosis is important to treat those affected and ... the help of a portable mini-lab or "lab on a ... affected areas and perform rapid testing for HIV. They do ...
Breaking Medicine Technology: