Navigation Links
Energy Supplement Under Study for Parkinson's Disease

Whether a supplement used by athletes to boost energy levels and build muscle can slow progression of Parkinson’s disease is the focus of a North American study. //

Creatine, under study for a number of neurological and neuromuscular diseases such as Lou Gehrig’s and muscular dystrophy, may help Parkinson’s patients by giving an energy boost to dying cells, says Dr. Kapil D. Sethi, neurologist and director of the Movement Disorders Program at the Medical College of Georgia.

“We think it may help cells that are damaged or overworked,” says Dr. Sethi, a site principal investigator on the National Institute of Neurological Disorders and Stroke study. MCG hopes to recruit 45 patients for the study that will enroll 1,720 patients at 51 sites in the United States and Canada.

Mitochondria, the powerhouse for cells, become dysfunctional in the brain, muscle and platelet cells of many patients with Parkinson’s disease, Dr. Sethi says. Powerhouse dysfunction is discernible in postmortem brain studies and in muscle biopsies and measures of platelet activity in the living.

“By giving more energy to the cell, you are giving them a safety margin,” Dr. Sethi says. “If a cell is dying, it takes another route and that would be surviving.”

The goal is to slow progression of a disease that affects about 1 million people in North America. Hallmarks include tremors, rigidity and slowed movement. Late in the disease, the majority of patients also develop dementia and behavior disorders.

Today’s therapies – including the gold standard, a synthetic dopamine called levodopa and MAO-B inhibitors that forestall breakdown of dopamine – are geared toward treating symptoms. Dopamine, a neurotransmitter critical to movement, is depleted in Parkinson’s. Researchers hope newer therapies, including creatine, can be added to the mix to help slow the disease.

The creatine study will enroll patients who have been on stan dard therapies from 90 days to two years and follow them for five years. Half the enrollees will get creatine and half placebo. The hope is for at least a 20 percent reduction in disease progression, so that at the end of five years, patients on creatine will look like placebo patients at four years, says Buff Dill, MCG study coordinator.

A number of methods will be used to periodically measure disease progression, including the Unified Parkinson’s Disease Rating Scale.

Following disease progression over many years and measuring endpoints such as falling, nursing home placement, dementia and death is the only way to effectively assess treatment for a disease that typically progresses slowly, Dr. Sethi says. In fact, the study may be extended five more years, based on preliminary results and funding, he says.

Those who get creatine may have the added benefit of increased muscle, as is true of athletes, Dr. Sethi says, noting that many patients experience muscle atrophy and weight loss.

Although creatine is available over the counter, he believes Parkinson’s patients will still be interested in the study. “Patients realize that we don’t know if it works. They are willing to take the risk of being on placebo for the cause of science and to learn more about the disease,” he says, noting the altruistic nature of many of his patients. “They want to beat this disease and if they can’t, they want to help somebody else beat it.”

Avicena Group, Inc., will provide creatine and placebo for this first large study in a series of National Institutes of Health-sponsored exploratory trials in Parkinson’s.

MCG will participate in a similar study of coenzyme Q10, another natural supplement that boosts energy production, later this year. Dr. Sethi, project director of the Parkinson Research Alliance of India, which is working to bring more clinical trials to his homeland, plans to incorporate these supplements into innovative treatment cocktails that will be studied there.


Sorce-Eurekalert
SRM
'"/>




Related medicine news :

1. Radiofrequency Energy Cooks Tumors Without Surgery
2. Energy intake directly related to portion size
3. Energy Therapy For Quicker Healing
4. Pollution Free Hydrogen based fuel for Energy
5. Obesity Can Be Caused By Consumption Of Energy Drinks
6. Bird Flu Likely To Reduce World Energy Demand
7. Alcohol-illusion: Alcohol and Energy Drinks Combo, Maintains Sobriety?
8. Energy Security Boosted by ADB in Asia
9. Boosting Energy Naturally
10. "Dynamic Energy Landscape" of enzyme in Catalysis
11. High-Energy Clamp Simplifies Heart Surgery for Atrial Fibrillation
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... ... viewers the lowdown on sciatica in a new episode of "Success Files," which ... current events and innovation and investigates each subject in-depth with passion and integrity. ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and ... of published author, William Nowers. Captain Nowers and his wife, Millie, have six ... years in the Navy. Following his career as a naval aviator and carrier ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest ... its plans to open a flagship location in Covington, LA at 401 N. U.S. ... Go store next to Office Depot in the Holiday Square shopping center. Its location ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) ... FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s ... Morris F. Collen, a pioneer in the field of medical informatics, this prestigious award ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa Mohebi, ... a medical article to the newly revamped Cosmetic Town journal section, ... hair transplant procedure known as Follicular Unit Extraction (FUE). , Dr. ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... MENLO PARK, Calif. , Oct. 11, 2017 /PRNewswire/ ... a national scientific team that developed an innovative way ... and quantity of the delivery of new drugs. ... the 2017 Fall Clinical Dermatology Conference will show how ... Massachusetts General Hospital, Harvard Medical School used a suite ...
(Date:10/11/2017)...  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided ... Piedras, Puerto Rico , where the ... Following a comprehensive onsite ... structural damage, temporary loss of power and minimal water ... manufacturing operations have resumed, and the company expects to ...
(Date:10/7/2017)... Oct. 6, 2017   Provista, a proven ... $100 billion in purchasing power, today announced a new ... The Newsroom is the online home for ... infographics, expert bios, news releases, slideshows and events. ... a wealth of resources at their fingertips, viewers can ...
Breaking Medicine Technology: