Navigation Links
Energy Supplement Under Study for Parkinson's Disease

Whether a supplement used by athletes to boost energy levels and build muscle can slow progression of Parkinson’s disease is the focus of a North American study. //

Creatine, under study for a number of neurological and neuromuscular diseases such as Lou Gehrig’s and muscular dystrophy, may help Parkinson’s patients by giving an energy boost to dying cells, says Dr. Kapil D. Sethi, neurologist and director of the Movement Disorders Program at the Medical College of Georgia.

“We think it may help cells that are damaged or overworked,” says Dr. Sethi, a site principal investigator on the National Institute of Neurological Disorders and Stroke study. MCG hopes to recruit 45 patients for the study that will enroll 1,720 patients at 51 sites in the United States and Canada.

Mitochondria, the powerhouse for cells, become dysfunctional in the brain, muscle and platelet cells of many patients with Parkinson’s disease, Dr. Sethi says. Powerhouse dysfunction is discernible in postmortem brain studies and in muscle biopsies and measures of platelet activity in the living.

“By giving more energy to the cell, you are giving them a safety margin,” Dr. Sethi says. “If a cell is dying, it takes another route and that would be surviving.”

The goal is to slow progression of a disease that affects about 1 million people in North America. Hallmarks include tremors, rigidity and slowed movement. Late in the disease, the majority of patients also develop dementia and behavior disorders.

Today’s therapies – including the gold standard, a synthetic dopamine called levodopa and MAO-B inhibitors that forestall breakdown of dopamine – are geared toward treating symptoms. Dopamine, a neurotransmitter critical to movement, is depleted in Parkinson’s. Researchers hope newer therapies, including creatine, can be added to the mix to help slow the disease.

The creatine study will enroll patients who have been on stan dard therapies from 90 days to two years and follow them for five years. Half the enrollees will get creatine and half placebo. The hope is for at least a 20 percent reduction in disease progression, so that at the end of five years, patients on creatine will look like placebo patients at four years, says Buff Dill, MCG study coordinator.

A number of methods will be used to periodically measure disease progression, including the Unified Parkinson’s Disease Rating Scale.

Following disease progression over many years and measuring endpoints such as falling, nursing home placement, dementia and death is the only way to effectively assess treatment for a disease that typically progresses slowly, Dr. Sethi says. In fact, the study may be extended five more years, based on preliminary results and funding, he says.

Those who get creatine may have the added benefit of increased muscle, as is true of athletes, Dr. Sethi says, noting that many patients experience muscle atrophy and weight loss.

Although creatine is available over the counter, he believes Parkinson’s patients will still be interested in the study. “Patients realize that we don’t know if it works. They are willing to take the risk of being on placebo for the cause of science and to learn more about the disease,” he says, noting the altruistic nature of many of his patients. “They want to beat this disease and if they can’t, they want to help somebody else beat it.”

Avicena Group, Inc., will provide creatine and placebo for this first large study in a series of National Institutes of Health-sponsored exploratory trials in Parkinson’s.

MCG will participate in a similar study of coenzyme Q10, another natural supplement that boosts energy production, later this year. Dr. Sethi, project director of the Parkinson Research Alliance of India, which is working to bring more clinical trials to his homeland, plans to incorporate these supplements into innovative treatment cocktails that will be studied there.


Sorce-Eurekalert
SRM
'"/>




Related medicine news :

1. Radiofrequency Energy Cooks Tumors Without Surgery
2. Energy intake directly related to portion size
3. Energy Therapy For Quicker Healing
4. Pollution Free Hydrogen based fuel for Energy
5. Obesity Can Be Caused By Consumption Of Energy Drinks
6. Bird Flu Likely To Reduce World Energy Demand
7. Alcohol-illusion: Alcohol and Energy Drinks Combo, Maintains Sobriety?
8. Energy Security Boosted by ADB in Asia
9. Boosting Energy Naturally
10. "Dynamic Energy Landscape" of enzyme in Catalysis
11. High-Energy Clamp Simplifies Heart Surgery for Atrial Fibrillation
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... ProVest Insurance Group, ... Dallas, Miami, and Raleigh regions, is organizing an extended charity drive to benefit ... deadly chromosome abnormality. , After struggling since birth with several health challenges, T.J. ...
(Date:10/13/2017)... ... October 13, 2017 , ... The International ... promote standards of excellence for the field of eating disorders, announces the opening ... 25, 2018 in Orlando, Florida at the Omni Resort at ChampionsGate. ...
(Date:10/13/2017)... LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for care ... is the 90-day elimination period, when the family pays for care, is often waived, ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob ... sciatica in a new episode of "Success Files," which is an award-winning educational ... and investigates each subject in-depth with passion and integrity. , Sciatica occurs when ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... now treating sleep apnea using cutting-edge Oventus O2Vent technology. As many ... sleep disorder characterized by frequent cessation in breathing. Oral appliances can offer significant ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... LAWRENCE, Mass. , Oct. 4, 2017 /PRNewswire/ ... developer of single-use, self-contained, illuminating medical devices, today ... National Health Surveillance Agency (or Agência Nacional ... ®. The first single-use, cordless surgical retractor with ... ONETRAC provides optimal access, illumination and exposure of ...
(Date:10/2/2017)... Denmark , Oct. 2, 2017 The Rebound ... in the struggle to reverse the tide of prescription drug ... for regulating their medicine intake and stepping down their dosage ... set to launch in December 2017; the first 100,000 people ... Learn more at http://www.rebound-solution.com/ ...
(Date:9/25/2017)... Sept. 25, 2017   Montrium , an ... solutions, today—from the IQPC Trial Master Files & ... NL)—announced that EastHORN Clinical Services has selected ... and TMF management. EastHORN, a leading European contract ... to increase transparency to enable greater collaboration with ...
Breaking Medicine Technology: