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Enbrel Joins with Methotrexate to Cure Rheumatoid Arthritis

painful and debilitating disease that has consequences not only for people with the condition but also for their families, friends and employers. It is vital that people with rheumatoid arthritis have access to treatments that have been proven effective to inhibit the progression of joint damage and to improve physical function.'

Stevo Knezevic, MD, PhD, chief medical officer of Wyeth Europe commented, 'These results clearly show rheumatoid arthritis patients on methotrexate or ENBREL monotherapy may benefit from treatment with the combination of ENBREL and methotrexate. It is important that health care providers make these therapies available as quickly as possible for appropriate patients.'

Rheumatoid arthritis affects approximately 0.5 to one per cent of the adult population worldwide, and about twice as many women as men suffer from the disease.2 It is a frequently progressive, destructive, chronic, systemic autoimmune disease of unknown aetiology.3 Patients with rheumatoid arthritis experience pain, inflammation, and morning stiffness, usually in the small joints of the hands and feet and often symmetrically. As the disease progresses, irreversible joint damage may lead to loss of function and physical disability. Rheumatoid arthritis can be a devastating disease that can negatively affect quality of life and may result in increased feelings of depression. During the first two to three years of the disease, 20 to 30 per cent of patients become permanently work disabled. Within 10 years of onset, at least 50 per cent of patients are unable to work. Because rheumatoid arthritis is a systemic disease, it can also lead to pulmonary, ocular, and cardiac complications.3

In the European Union, ENBREL is approved alone or in combination with methotrexate for the treatment of active rheumatoid arthritis in adults when the response to disease-modifying antirheumatic drugs, including methotrexate (unless contraindicated), has been inadequa
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