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Enbrel Joins with Methotrexate to Cure Rheumatoid Arthritis

ful and swollen; I found it difficult to walk, grip things, get dressed in the morning and generally live my life. Over the last four years of treatment, my quality of life has improved, and I experience less disability.'1

The results of the 227 patient one-year open-label extension of the TEMPO study showed that the combination therapy with ENBREL and methotrexate demonstrated clinical improvement and was generally well-tolerated during the one-year study.1 Fifty per cent of patients taking ENBREL and methotrexate for four years achieved clinical remission based on the disease activity score (DAS) of less than 1.6, the primary clinical efficacy endpoint, compared with 38.7 per cent at three years.1 Seventy-four per cent of patients taking ENBREL and methotrexate for four years achieved a DAS of less than 2.4 (low disease activity) compared with 66.7 per cent at three years.1 DAS is a combined index to measure disease activity in rheumatoid arthritis patients and is a validated tool used in clinical trials and serves as the basis for the EULAR response criteria. In addition, the data also demonstrate that among the rheumatoid arthritis patients treated with methotrexate monotherapy for three years, whose mean disease activity was moderate, the addition of ENBREL provided further improvement in clinical efficacy that approached the response achieved by patients treated with combination therapy for four years (mean DAS 1.9 vs. 1.8, respectively).1 The addition of methotrexate to patients who received ENBREL monotherapy for three years also resulted in improvements at four years (mean DAS 2.2)1. The proportions of subjects achieving clinical remission by adding ENBREL to methotrexate and adding methotrexate to ENBREL at four years were 41.8% and 38.2% and were not statistically different from each other nor compared to the combination group.

Ailsa Bosworth, chief executive, National Rheumatoid Arthritis Society, UK said, 'Rheumatoid arthritis is a
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