( An international one year TEMPO trial r...)Enbrel Joins with Methotrexate to Cure Rheumatoid Arthritis,Health

An international one year TEMPO trial reports in addition to the usual methotrexate therapy, rheumatoid arthritis patients also benefits //from ENBREL* (etanercept), a biological treatment. A report presented in the Annual European Congress of Rheumatology, (the European League Against Rheumatism (EULAR)), 2006, also proves its efficiency in a combination treatment.

The TEMPO extension trial was an open-label 52 week study involving subjects who had completed the 3-year double-blind TEMPO trial. At the end of the 3-year TEMPO trial, 227 subjects who met the specific predefined criteria continued into the 1-year, open-label extension. All subjects received treatment with the combination of ENBREL and methotrexate. Subjects receiving methotrexate monotherapy during the 3-year double-blind TEMPO trial were switched to the combination of ENBREL and methotrexate (n = 55). Subjects receiving ENBREL monotherapy during the 3-year double-blind TEMPO trial were switched to the combination of ENBREL and methotrexate (n = 76). Subjects receiving combination therapy during the 3-year double-blind TEMPO trial were continued on the same regimen (n = 96).

Commenting on the implications of the results, study investigator Dr Emilio Martín Mola, chief of the rheumatology department, Hospital Universitario de La Paz in Madrid and professor, Universidad Autónoma de Madrid, Spain said: 'Patients with rheumatoid arthritis, who have active disease after an adequate regimen of methotrexate, can improve significantly when etanercept is added. Whether newly diagnosed patients with active rheumatoid arthritis should be put on this combination regimen is a matter for discussion, but it is a good therapeutic strategy for those patients with aggressive, rheumatoid arthritis.'

Heather Widnall, UK, who has rheumatoid arthritis and took the combination of ENBREL and methotrexate for four years said, 'Before I started taking ENBREL and methotrexate, my joints were pain
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