Navigation Links
Emotional Stress Could Be a Factor in Causing Alzheimers: Study

Researchers at the Salk Institute for Biological Studies have found in a study of mice that repeated emotional stress, the kind humans experience in everyday life, may contribute to the accumulation of neurofibrillary tangles in the animal, which is a hallmark of Alzheimers disease.

The researchers say that while aging is still the greatest risk factor for Alzheimers disease, a number of studies have pointed to stress as a contributing factor.

A long-term study of about 800 members of religious orders had found that the people who were most prone to stress were twice as likely to develop Alzheimers disease, but the nature of the link between the two has been elusive, says lead researcher Dr. Paul E. Sawchenko, a professor in the Neuronal Structure and Function Laboratory.

The study, published in the Journal of Neuroscience, suggests that the brain-damaging effects of negative emotions are relayed through the two known corticotropin-releasing factor receptors, namely CRFR1 and CRFR2, which are part of a central switchboard that mediates the bodys responses to stress and stress-related disorders.

In Alzheimer's disease, as well as various other neurodegenerative conditions, phosphate groups are attached to tau protein, as a result of which the protein looses its grip on the microtubules, and starts to collapse into insoluble protein fibers, which ultimately cause cell death.

Previous studies had shown that extreme physiological stress, such as plunging mice into ice water or starving them for three days, can induce tau phosphorylation.

But what we wanted to know was whether exposure to milder stress, of the kind we experience in our daily lives, can induce tau phosphorylation, explains senior research associate and first author Dr. Robert A. Rissman.

When the researchers restrained mice for half an hour, it resulted only in a transient phosphorylation of tau. But when they simulated chronic stress by repeating the procedure every day for two weeks, the modification lasted long enough to let tau molecules tumble off the cytoskeleton and pile up in insoluble heaps of protein.

During the study, the researchers genetically engineered mice to lack either CRFR1 or CRFR2.

And sure enough, the CRF receptors turn out to be integrally and differentially involved, says Sawchenko.

In the absence of CRFR1, stress-induced tau phosphorylation was abrogated, while in mice missing CRFR2 the effect was amplified, says the researcher, adding that pharmacological studies with small molecule inhibitors replicated the effect.

We may have discovered another application. Such drugs could have a prophylactic effect or delay the progression of Alzheimers disease, Sawchenko says.


'"/>




Related medicine news :

1. Emotional trigger to smoke
2. Emotional callers hamper speedy ambulance dispatch
3. Emotional intelligence in Cancer
4. MRI Shows Emotional Changes During Menstrual Cycle
5. ‘Marriage Squabbles’ bad for both Emotional and Physical Wound
6. You Can Be Emotional And Logical
7. Breast Cancer Survivors Emotional Recovery Is Rapid After Treatment
8. Parental Conflicts Lead To Emotional Insecurity In Children
9. Job Or Emotional Stress Can Increase Risk Of Heart Attack
10. Baby Bottle Tooth Decay Affects Kids Physically and Emotionally
11. Emotional Engagement of Husband - A Final Answer To What Women Want
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer care, ... remain in the eye of the beholder, according to experts who offered insights and ... Journal of Managed Care. For the full issue, click here . , For ...
(Date:6/26/2016)... , ... June 26, 2016 , ... Pixel Film Studios ... X. , "Film editors can give their videos a whole new perspective by using ... - CEO of Pixel Film Studios. , ProSlice Levels contains over 30 Different ...
(Date:6/26/2016)... NC (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind and ... to be personalized through a fitness app. The fitness app plans to fix the two ... currently only offer a one size fits all type program , They don’t ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts ... applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention ... health care topics including advance care planning, healthcare costs and patient and family ...
(Date:6/25/2016)... Miami, FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton ... Plant City Observer , brings up a new, often overlooked aspect of head lice: ... The closing for fumigation is not a common occurrence, but a necessary one in the ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... June 27, 2016  VMS Rehab Systems, Inc. ( ... take whatever measures required to build a strong and ... is currently listed on the OTC Markets-pink current trading ... and CEO, "We are seeing an anomaly in market ... not only by the Company, but shareholders and market ...
(Date:6/24/2016)... 2016  Consumers have taken a more active ... more emphasis on patient outcomes. ... the pharmaceutical industry have evolved beyond just providing ... are focusing on becoming more patient-oriented across their ... services that improve health. ...
(Date:6/24/2016)... June 24, 2016  Global Blood Therapeutics, Inc. (GBT) ... developing novel therapeutics for the treatment of grievous ... the closing of its previously announced underwritten public ... the public offering price of $18.75 per share. ... offered by GBT. GBT estimates net proceeds from ...
Breaking Medicine Technology: