Navigation Links
Emotional Stress Could Be a Factor in Causing Alzheimers: Study

Researchers at the Salk Institute for Biological Studies have found in a study of mice that repeated emotional stress, the kind humans experience in everyday life, may contribute to the accumulation of neurofibrillary tangles in the animal, which is a hallmark of Alzheimers disease.

The researchers say that while aging is still the greatest risk factor for Alzheimers disease, a number of studies have pointed to stress as a contributing factor.

A long-term study of about 800 members of religious orders had found that the people who were most prone to stress were twice as likely to develop Alzheimers disease, but the nature of the link between the two has been elusive, says lead researcher Dr. Paul E. Sawchenko, a professor in the Neuronal Structure and Function Laboratory.

The study, published in the Journal of Neuroscience, suggests that the brain-damaging effects of negative emotions are relayed through the two known corticotropin-releasing factor receptors, namely CRFR1 and CRFR2, which are part of a central switchboard that mediates the bodys responses to stress and stress-related disorders.

In Alzheimer's disease, as well as various other neurodegenerative conditions, phosphate groups are attached to tau protein, as a result of which the protein looses its grip on the microtubules, and starts to collapse into insoluble protein fibers, which ultimately cause cell death.

Previous studies had shown that extreme physiological stress, such as plunging mice into ice water or starving them for three days, can induce tau phosphorylation.

But what we wanted to know was whether exposure to milder stress, of the kind we experience in our daily lives, can induce tau phosphorylation, explains senior research associate and first author Dr. Robert A. Rissman.

When the researchers restrained mice for half an hour, it resulted only in a transient phosphorylation of tau. But when they simulated chronic stress by repeating the procedure every day for two weeks, the modification lasted long enough to let tau molecules tumble off the cytoskeleton and pile up in insoluble heaps of protein.

During the study, the researchers genetically engineered mice to lack either CRFR1 or CRFR2.

And sure enough, the CRF receptors turn out to be integrally and differentially involved, says Sawchenko.

In the absence of CRFR1, stress-induced tau phosphorylation was abrogated, while in mice missing CRFR2 the effect was amplified, says the researcher, adding that pharmacological studies with small molecule inhibitors replicated the effect.

We may have discovered another application. Such drugs could have a prophylactic effect or delay the progression of Alzheimers disease, Sawchenko says.


Related medicine news :

1. Emotional trigger to smoke
2. Emotional callers hamper speedy ambulance dispatch
3. Emotional intelligence in Cancer
4. MRI Shows Emotional Changes During Menstrual Cycle
5. ‘Marriage Squabbles’ bad for both Emotional and Physical Wound
6. You Can Be Emotional And Logical
7. Breast Cancer Survivors Emotional Recovery Is Rapid After Treatment
8. Parental Conflicts Lead To Emotional Insecurity In Children
9. Job Or Emotional Stress Can Increase Risk Of Heart Attack
10. Baby Bottle Tooth Decay Affects Kids Physically and Emotionally
11. Emotional Engagement of Husband - A Final Answer To What Women Want
Post Your Comments:

(Date:6/24/2016)... ... ... A recent article published June 14 on E Online details ... to state that individuals are now more comfortable seeking to undergo not only the ... and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) notes ...
(Date:6/24/2016)... ... ... crisis. Her son James, eight, was out of control. Prone to extreme mood shifts and ... him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife on ... say he was going to kill them. If we were driving on the freeway, ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a ...
(Date:6/24/2016)... , ... June 24, 2016 , ... People across the ... Genome magazine’s Code Talker Award, an essay contest in which patients and their families ... to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education ...
(Date:6/24/2016)... Vegas, Nevada (PRWEB) , ... June 24, 2016 ... ... Las Vegas client, The Grove Investment Group (TGIG), has initiated cultivation and processing ... Grove, in Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 Roche ... received 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) ... severe sepsis or septic shock. With this clearance, Roche ... provide a fully integrated solution for sepsis risk assessment ... associated with bacterial infection and PCT levels in blood ...
(Date:6/23/2016)... 2016 Research and Markets has announced ... report to their offering. ... a favourable commercial environment for MedImmune to enter. The US ... will serve to drive considerable growth for effective anti-influenza medications. ... cap sales considerably, but development is still in its infancy. ...
(Date:6/23/2016)... and INDIANAPOLIS , June ... receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship is any ... scholarship winners, announced today online at ... type 1 diabetes stand in the way of academic ... supported the Foundation,s scholarship program since 2012, and continues ...
Breaking Medicine Technology: