Navigation Links
Emory Participates in Study to Slow Progression of Parkinson's Disease

Emory University is participating in one of the largest ever Parkinson's disease (PD) clinical trials to determine if the nutritional supplement creatine can slow the symptom progression of this disorder.

PD is a degenerative disorder of the brain in which patients develop tremor, slowness of movements and stiffness of muscles. It affects at least one million people in the U.S. Currently, there are a number of effective treatments to mask the symptoms but none to slow their progression.

Emory is among 51 medical centers in the U.S. and Canada recruiting the 1,720 participants with early-stage PD required to complete this study. The double-blind, placebo-controlled, phase III study is the first large national study following a series of smaller clinical trials sponsored by the National Institutes of Health (NIH).

"The premise for this important research study is supported by a large body of laboratory data and the promising results of an earlier smaller clinical study of creatine in Parkinson's disease," says Dr. Jorge Juncos, primary investigator at Emory University.

"If positive, the results will have a lasting impact in the treatment of all stages of this illness," says Dr. Juncos. "Our goal is to offer enhanced therapies to patients with Parkinson's that will improve their quality of life and slow the progression of symptoms."

Creatine is marketed as a nutritional supplement, but is not an approved therapy for PD or any other condition. Studies have suggested that it can improve energy production by the mitochondria, the "powerhouse" of cellular metabolism. In persons without PD and in patients with PD, it can improve exercise performance so long as the person is also exercising regularly. It is important to note that creatine is no substitute for exercise and its short-term use in PD does not directly affect motor symptoms, says Dr. Juncos.

Creatine also acts as an antioxidant t o prevent damage from compounds that are harmful to cells in the brain. In mouse model studies of PD, creatine was able to prevent the loss of the dopamine cells in the brain, the same cells that are also affected in PD.

"This study is an example of our commitment to Parkinson's research," says Story C. Landis, PhD, director of the National Institute of Neurological Disorders and Stroke (NINDS), the NIH institute leading the study. "We are trying to explore every possible option for reducing the burden of this disease."

The study will enroll people who have been diagnosed with PD within the past five years and who have been treated for two years or less with levodopa or other drugs that improve dopamine transmission in the brain. Many of the symptoms of PD result from the loss of dopamine, a brain chemical that helps to control movement. Half of the participants will receive creatine and half will receive a placebo. Neither the participants nor their doctors will know which treatment to which the participants have been assigned.

The investigators will measure disease progression using standard rating scales that measure quality of life, cognitive function, walking and the ability to carry out other activities of daily living.


'"/>




Related medicine news :

1. Researchers from Emory University Undertake A New Genetic Mapping
2. First Ultrasound Thrombolysis in U.S. Performed at Emory University Hospital
3. NIH Awards Emory $3.6 Million for Schizophrenia Gene Research
4. Death and Disability from Brain Injury Reduced, Emory Researchers Report
5. Tomato Sauce reduces Cancer Risk- Study
6. Study on obesity and heart failure
7. National Lung Study in the process
8. Study casts doubt on keyboard ills
9. Study reveals how stress can make you sick
10. Study reveals how stress can make you sick
11. Study supports vegetable diet
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/2/2016)... ... December 02, 2016 , ... Mediaplanet’s newest ... patients, standing as living proof that attitude and determination can combine into the ... that spike around the holidays. This campaign will offer patients a new-found hope, ...
(Date:12/2/2016)... ... December 02, 2016 , ... The PAINWeekEnd ... Beach Resort and Spa in Honolulu, offering local frontline clinicians the opportunity to ... , The demand for supplemental training related to pain management has surged ...
(Date:12/2/2016)... ... December 02, 2016 , ... "Pro3rd Accents Volume 2 ... to create versatile lower third titles with just a few clicks of the mouse," ... 2 includes 30 lower third animations. Choose from various styles with accented animations, rigid ...
(Date:12/2/2016)... Miami, FL (PRWEB) , ... December 02, 2016 , ... ... they are winners of $1,000 each from the National Family Partnership and the Drug ... winning families who decorated their homes and the 10 winning schools who decorated their ...
(Date:11/30/2016)... ... November 30, 2016 , ... ... treatment has announced the opening of a new eating disorder treatment center location ... outpatient treatment for adults and adolescents, both males and females ages 10 and ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... SPRING, Md. , Dec. 2, 2016 ... new indication for Jardiance (empagliflozin) to reduce the risk ... diabetes mellitus and cardiovascular disease. "Cardiovascular ... with type 2 diabetes mellitus," said Jean-Marc Guettier ... and Endocrinology Products in FDA,s Center for Drug Evaluation ...
(Date:12/2/2016)... , December 2, 2016 ... global cardiac pacemaker market in its upcoming report titled, "Global Market Study ... a Declining CAGR of -1.4% between 2016 and 2024". The ... Mn in 2015 and this is likely to decline ... revenue, the global cardiac pacemaker market is anticipated to ...
(Date:12/2/2016)... , December 2, 2016 According to ... "Global Market Study on Automated Endoscope Reprocessors: Single Basin Automated ... of 8.6% Between 2016 and 2024 " the global automated endoscope reprocessors ... expected to expand at a CAGR of 7.2% during an ... US$ 1,367.6 Mn by 2024. ...
Breaking Medicine Technology: