Navigation Links
Emergency Heart Patients Do Better With Invasive Approach

Patients admitted to the hospital for sudden, worsening chest pain or a certain type of heart attack have better outcomes if they undergo early invasive treatment// rather than being treated conservatively, a new review of clinical trials has found.

“Available evidence suggests that an early invasive strategy is superior to a conservative strategy,” said lead author Michel Hoenig of the Centre for Research in Vascular Biology at the University of Queensland in Australia. “However, we are far from having as solid an answer as we need given the prevalence and costs associated with treating this disease.”

The review appears in the current issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that evaluates research in all aspects of health care. Systematic reviews draw evidence-based conclusions about medical practice after considering both the content and quality of existing trials on a topic.

The researchers looked at two heart conditions: unstable angina, which is acute, accelerating chest pain, and a kind of heart attack known as non-ST-elevation myocardial infarction, which is diagnosed in part by ECG.

Together, these conditions account for 1.4 million hospital admissions yearly in the United States, far surpassing admissions for other cardiac disorders. Although the risks of death, heart attack and other unfavorable outcomes vary widely among patients with these disorders, cardiologists classify them as a single acute coronary syndrome.

The Cochrane reviewers pooled findings from five major randomized controlled trials that compared an early invasive approach to a conservative approach in patients with this acute coronary syndrome.

They looked at differences in the death and heart attack rates both during the initial hospitalization and in the long term. They also looked at differences in rates of intractable angina and rehospitalization dur ing the first six to 12 months after the initial event.

The early invasive approach was superior to the conservative approach for all of these outcomes.

In the early invasive approach, a cardiologist looks for narrowing or blockage in the coronary arteries with angiography, an imaging test using a cardiac catheter. Patients with significant obstruction are treated with angioplasty, in which a balloon is inflated to widen the artery, followed by insertion of a stent to keep the vessel open. Some patients with narrowing or blockage instead require bypass surgery.

In the conservative approach, patients are treated in the hospital with medication. Only those whose symptoms persist or worsen, or who have evidence of artery narrowing on noninvasive tests, undergo invasive procedures.

Supporters of the conservative approach maintain that, once patients have been stabilized with medical therapy, noninvasive tests can be used to identify high-risk patients who would be most likely to benefit from invasive treatment.

Of study participants, patients in the early invasive group were about one-third less likely to have uncontrolled chest pain or to be rehospitalized six to 12 months after hospitalization. Based on the two trials with the longest follow-up, patients in the early invasive group also had a 25 percent lower risk of dying or suffering a second heart attack two to five years after the initial event.

However, the early invasive approach was not without risks. Patients randomized to early invasive treatment had a twofold increased risk of procedure-related heart attack and an increased risk of bleeding during the initial hospitalization.

According to William Boden, M.D., chief of cardiology at Buffalo General Hospital, this finding underscores the importance of factoring in an individual patient’s level of risk when considering whether to proceed with invasive treatment.

“Com mon to all of the trials is this hazard of increased death or heart attack within the first seven days or so of a catheter-based procedure,” said Boden. “This is why I think it’s important to risk-stratify patients, because the early hazard would be magnified in the low-risk patient and would be mitigated to a degree in the high-risk patient.”

The reviewers came to a similar conclusion when they looked at which patients were most likely to benefit from the early invasive approach. In two of the studies, only patients who were considered at high risk based on ECG findings or lab test results had a reduced risk of death or heart attack with the early invasive approach.

In one study that used a composite measure of risk called the TIMI risk score, a reduced risk of death, heart attack or rehospitalization was seen only for patients with intermediate or high risk who underwent an early invasive approach.

“Clearly we do not want to catheterize every patient who walks in the door with chest pain,” said Hoenig.

Harvard Medical School professor Elliott Antman, M.D., agreed with the review’s conclusions, but said that findings from randomized controlled trials don’t always translate perfectly to the real world.

“We need effectiveness trials, not just efficacy trials,” he said. “An effectiveness trial informs us about how well the efficacy observed in randomized controlled trials holds up when tested in routine clinical practice rather than in the artificial environment of a clinical trial.”

Hoenig agreed that more contemporary trials are needed and added that improving the medical care that patients receive after their initial hospitalization is also important.

“Some data suggest that the treatment of [these] patients follows guidelines only about 75 percent of the time,” he said. “To improve outcomes in patients with acute coronary syndromes, we need to get better at doing the simple — and o ften cheap — things first.”

(Source: Newswise)
'"/>




Related medicine news :

1. Gas Masks Dont Always Fit an Emergency
2. London Emergency Services Receive Wide Appreciation
3. WHO declares Tuberculosis – ‘An Emergency’ in Afrca
4. Indian Health Ministry approves sale of Emergency contraceptives as over the counter drug
5. Emergency Treatment Found Wanting In Anaphylactic Reactions
6. Chlamydia Screening To Be Offered With Emergency Contraception
7. Apollo And Stanford Team To Train Emergency Medical Technicians
8. Mumbai To Get Emergency Ambulance Service
9. Extravagant Pay For Emergency Department Head Of Caboolture Hospital
10. Andhra Junior Doctors Call Off Strike Partially; To Attend Emergency cases
11. Nursing Home Residents Receive Appropriate Emergency Care Despite Poor Funds
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
(Date:6/24/2016)... ... 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida ... their peers for this recognition are considered among the top 2 percent of lawyers ... as members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, ... minimum wage raise to $12 an hour by 2020 and then adjusting it yearly to ... value of the minimum wage, assure the wage floor does not erode again, and make ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty Network, affiliated ... Weintraub as a prominent plastic surgeon and the network’s newest partner. , ... most handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands ...
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm Slone ... executive with extensive sequencing and genomics experience, as Vice President of North American Capital ... will be responsible for leading the sales team in the commercialization of the HTG ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... --  Pulmatrix, Inc ., (NASDAQ: PULM ), ... today that it was added to the Russell Microcap ... set of U.S. and global equity indexes on June ... for Pulmatrix," said Chief Executive Officer Robert Clarke ... in developing drugs for crucial unmet medical needs, and ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... - Forecast to 2022" report to their offering. ... for the patients with kidney failure, it replaces the function ... the patient,s blood and thus the treatment helps to keep ... in balance. Increasing number of ESRD patients ...
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... BRAHMS PCT (procalcitonin) assay as a dedicated testing solution ... this clearance, Roche is the first IVD company in ... sepsis risk assessment and management. PCT is ... levels in blood can aid clinicians in assessing the ...
Breaking Medicine Technology: