Navigation Links
Elevating Manganese Levels hold back HIV

According to researchers at the Hopkins University, working with yeast have made the unexpected discovery the metal manganese can block the replication of HIV inside cells, a finding that could lead to a whole new class of treatments for the virus that causes AIDS.// A team of researchers at Hopkins University in Baltimore found that, human immunodeficiency virus depends on an enzyme called reverse transcriptase to replicate, and higher than normal levels of manganese lower the activity of a similar enzyme used by a virus-like component of yeast.

Further research determined increasing manganese also lowers the activity of HIV's reverse transcriptase, which could block replication of the virus and help prevent it from causing acquired immune deficiency syndrome.

According to Jef Boeke, professor of molecular biology at Hopkins University, if drugs could be grown that increase manganese levels, it would be a innovative approach to treating HIV. Boeke said his team currently is looking for drugs that do just that. The higher levels of manganese in yeast were caused by a defective gene called PRM1, which produces a protein that shuttles manganese out of cells. The Hopkins scientists, felt that they human equivalent of PRM1 will be a good target for drugs designed to treat HIV infection. Boeke cautioned, however, it is not yet known whether raising manganese levels in humans will have any therapeutic effect.

One of the first treatments for HIV infection, the antiretroviral zidovudine (AZT), targeted reverse transcriptase. The virus is notorious for developing resistance to drugs, however, so new treatments are needed to keep it in check. Drugs that target PRM1 and increase manganese levels may help prevent the development of resistance, Boeke said.

HIV may still develop resistance but "a new class of agents would still be really useful because what has really been successful is combining drugs," he said.

Carl Dief fenbach, associate director for basic sciences in the AIDS program at the National Institutes of Health's Institute of Allergy and Infectious Diseases in Bethesda, Md., said the research was done in a test tube and adjusting metal ion concentrations in the body could have completely different results.

Dieffenbach told UPI the study will spur a flurry of research to further understand whether the PRM1 gene is a viable target to develop drugs around. His first step will be to do a study in mice. At the same time, researchers also can look at people infected with HIV and see if they can detect any with a defect in the PRM1 gene. If they do find a defect, they can determine if they are protected from HIV infection or have a slower progression of disease.


'"/>




Related medicine news :

1. Levels Of Blood Proteins May Help Heart Disease Care
2. Elevated Ozone Levels Hurt Sperm Count
3. High Levels of Protein Linked to Brain Shrinkage
4. Chickens Found To Have High Levels of Arsenic
5. Low Protein Levels A Possible Indicator For A Miscarriage
6. Low Testosterone Levels the Cause Of Depression In Men
7. Weather Found To Play An Important Role In Cholesterol Levels
8. Education Levels Found To Predict Stress
9. Effective Control Of Blood Sugar Levels
10. Elevated Blood Sugar Levels A Risk Factor Of Heart Disease
11. Better Control Of Sugar Levels
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/5/2016)... NY & Salt Lake City, UT (PRWEB) , ... February 05, ... ... Founder of Activz Whole-Food Nutrition , announced that the much-anticipated feature with author ... the New Really Cool Humans Amateur TV Network. , Each week, on his weekly ...
(Date:2/5/2016)... ... February 05, 2016 , ... The event is being held ... Event Center in Minneapolis, Minn. Triumph Over Parkinson’s will fund nearly $100,000 for research ... Schneiderman’s Furniture, lives with Parkinson’s disease and is the architect of this informative event ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... addition of micro-needling services in their Napa Valley office. The technique utilizes the ... Surgery Associates, Dr. Canales and Dr. Furnas, are part of only a select ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... H. Van Allen have signed a joint enrollment and degree completion agreement. ... toward associate and baccalaureate degrees at FHU|Dickson. , The agreement allows students ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... exclusively to funding innovative lymphoma research and serving the lymphoma community through a ... to once again host, Swirl, A Wine Tasting Event at the La Gorce ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... , Feb. 4, 2016 Wegener Polyangiitis ... Global Markets Direct,s, ,Wegener Polyangiitis - Pipeline Review, ... Polyangiitis,s therapeutic pipeline. This report provides comprehensive ... complete with comparative analysis at various stages, therapeutics ... route of administration (RoA) and molecule type, along ...
(Date:2/4/2016)... 4, 2016 Frontier Pharma: Chronic Obstructive ... Innovation Chronic Obstructive Pulmonary Disease ... inflammation of the airways and lungs. Persistent breathing ... the disease one of the leading causes of ... the world. COPD is linked to cumulative exposure ...
(Date:2/4/2016)... SILVER SPRING, Md. , Feb. 4, 2016 ... Robert Califf , the FDA,s Deputy Commissioner for Medical Products ... far-reaching action plan to reassess the agency,s approach to opioid ... the epidemic, while still providing patients in pain access to ... The FDA will: , Re-examine the risk-benefit ...
Breaking Medicine Technology: