Navigation Links
Elevating Manganese Levels hold back HIV

According to researchers at the Hopkins University, working with yeast have made the unexpected discovery the metal manganese can block the replication of HIV inside cells, a finding that could lead to a whole new class of treatments for the virus that causes AIDS.// A team of researchers at Hopkins University in Baltimore found that, human immunodeficiency virus depends on an enzyme called reverse transcriptase to replicate, and higher than normal levels of manganese lower the activity of a similar enzyme used by a virus-like component of yeast.

Further research determined increasing manganese also lowers the activity of HIV's reverse transcriptase, which could block replication of the virus and help prevent it from causing acquired immune deficiency syndrome.

According to Jef Boeke, professor of molecular biology at Hopkins University, if drugs could be grown that increase manganese levels, it would be a innovative approach to treating HIV. Boeke said his team currently is looking for drugs that do just that. The higher levels of manganese in yeast were caused by a defective gene called PRM1, which produces a protein that shuttles manganese out of cells. The Hopkins scientists, felt that they human equivalent of PRM1 will be a good target for drugs designed to treat HIV infection. Boeke cautioned, however, it is not yet known whether raising manganese levels in humans will have any therapeutic effect.

One of the first treatments for HIV infection, the antiretroviral zidovudine (AZT), targeted reverse transcriptase. The virus is notorious for developing resistance to drugs, however, so new treatments are needed to keep it in check. Drugs that target PRM1 and increase manganese levels may help prevent the development of resistance, Boeke said.

HIV may still develop resistance but "a new class of agents would still be really useful because what has really been successful is combining drugs," he said.

Carl Dief fenbach, associate director for basic sciences in the AIDS program at the National Institutes of Health's Institute of Allergy and Infectious Diseases in Bethesda, Md., said the research was done in a test tube and adjusting metal ion concentrations in the body could have completely different results.

Dieffenbach told UPI the study will spur a flurry of research to further understand whether the PRM1 gene is a viable target to develop drugs around. His first step will be to do a study in mice. At the same time, researchers also can look at people infected with HIV and see if they can detect any with a defect in the PRM1 gene. If they do find a defect, they can determine if they are protected from HIV infection or have a slower progression of disease.


'"/>




Related medicine news :

1. Levels Of Blood Proteins May Help Heart Disease Care
2. Elevated Ozone Levels Hurt Sperm Count
3. High Levels of Protein Linked to Brain Shrinkage
4. Chickens Found To Have High Levels of Arsenic
5. Low Protein Levels A Possible Indicator For A Miscarriage
6. Low Testosterone Levels the Cause Of Depression In Men
7. Weather Found To Play An Important Role In Cholesterol Levels
8. Education Levels Found To Predict Stress
9. Effective Control Of Blood Sugar Levels
10. Elevated Blood Sugar Levels A Risk Factor Of Heart Disease
11. Better Control Of Sugar Levels
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... or dementia. However, many long-term care insurance companies have a waiver for care if ... the 90-day elimination period, when the family pays for care, is often waived, so ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run ... This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed ... geared towards children of all ages; it is a non-competitive, non-timed event, which is ...
(Date:10/13/2017)... ... 2017 , ... Coveros, a leader in agile coaching services ... by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile Transformation ... Agile methodologies in a consistent and high value manner across CMS programs. Coveros ...
(Date:10/12/2017)... Del. (PRWEB) , ... October 12, 2017 , ... ... and advisory services for healthcare compliance program management, will showcase a range of ... National Association for Assisted Living (NCAL) Convention and Expo to be held October ...
(Date:10/12/2017)... ... 12, 2017 , ... The company has developed a suite ... regulatory authorities worldwide. From Children’s to Adults 50+, every formula has been developed ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... -- AVACEN Medical , Inc. (AVACEN) announced that Frost ... Product Innovation Award for Its fibromyalgia pain management device. ... device market research by Frost & Sullivan,s industry experts. ... relief product, the AVACEN 100, offers a safe and effective ... ...
(Date:10/11/2017)... , Oct. 11, 2017  True Health, ... has amplified its effort during National Breast Cancer ... hereditary cancer risks. ... Clinical Oncology calculated that more than 10 million ... inherited mutations in BRCA1 or BRCA2 and have not ...
(Date:10/5/2017)... 2017  In response to the nationwide opioid ... Surgeons (AAOMS) released prescribing recommendations that urge ibuprofen ... as a first-line therapy to manage a patient,s ... Recognizing the value and importance of ... Prescribing: Acute and Postoperative Pain Management" stresses that ...
Breaking Medicine Technology: