Navigation Links
Elevating Manganese Levels hold back HIV

According to researchers at the Hopkins University, working with yeast have made the unexpected discovery the metal manganese can block the replication of HIV inside cells, a finding that could lead to a whole new class of treatments for the virus that causes AIDS.// A team of researchers at Hopkins University in Baltimore found that, human immunodeficiency virus depends on an enzyme called reverse transcriptase to replicate, and higher than normal levels of manganese lower the activity of a similar enzyme used by a virus-like component of yeast.

Further research determined increasing manganese also lowers the activity of HIV's reverse transcriptase, which could block replication of the virus and help prevent it from causing acquired immune deficiency syndrome.

According to Jef Boeke, professor of molecular biology at Hopkins University, if drugs could be grown that increase manganese levels, it would be a innovative approach to treating HIV. Boeke said his team currently is looking for drugs that do just that. The higher levels of manganese in yeast were caused by a defective gene called PRM1, which produces a protein that shuttles manganese out of cells. The Hopkins scientists, felt that they human equivalent of PRM1 will be a good target for drugs designed to treat HIV infection. Boeke cautioned, however, it is not yet known whether raising manganese levels in humans will have any therapeutic effect.

One of the first treatments for HIV infection, the antiretroviral zidovudine (AZT), targeted reverse transcriptase. The virus is notorious for developing resistance to drugs, however, so new treatments are needed to keep it in check. Drugs that target PRM1 and increase manganese levels may help prevent the development of resistance, Boeke said.

HIV may still develop resistance but "a new class of agents would still be really useful because what has really been successful is combining drugs," he said.

Carl Dief
'"/>




Page: 1 2

Related medicine news :

1. Levels Of Blood Proteins May Help Heart Disease Care
2. Elevated Ozone Levels Hurt Sperm Count
3. High Levels of Protein Linked to Brain Shrinkage
4. Chickens Found To Have High Levels of Arsenic
5. Low Protein Levels A Possible Indicator For A Miscarriage
6. Low Testosterone Levels the Cause Of Depression In Men
7. Weather Found To Play An Important Role In Cholesterol Levels
8. Education Levels Found To Predict Stress
9. Effective Control Of Blood Sugar Levels
10. Elevated Blood Sugar Levels A Risk Factor Of Heart Disease
11. Better Control Of Sugar Levels
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Elevating Manganese Levels hold back HIV

(Date:5/3/2015)... “ BolehVPN ” was featured on NewsWatch as ... and coolest technology products available to consumers. Scott Steinberg, a ... and shared with viewers how to protect their private information. ... on computers and even more so online. It helps everyone ... over the world. In terms of work, the internet makes ...
(Date:5/3/2015)... It is not too late to register to take part in ... Anne Been in Arnold, Missouri on May 9, 2015. Family ... her loving memory. It has benefited the renowned Brain Aneurysm Foundation ... Lissa suffered a brain aneurysm . After two operations and ... is designed to serve as a remembrance of her and to ...
(Date:5/2/2015)... Vancouver fencing company, QS Fencing, has recently announced that its ... related to their questions on railings and gates. Many people ... and patios. While that seems like an easy task, there ... rolls up their sleeve to start working. One of the ... gate that matches it. , Instead of spending hours worrying ...
(Date:5/2/2015)... We are pleased to announce the Sun ... one of the Top Workplaces of 2015. , The ... field for their ethics and standards of excellence. The ... their educational efforts. The Delray Recovery Center prides itself ... purpose – to help individuals heal from the disease ...
(Date:5/2/2015)... (PRWEB) May 02, 2015 As ... laxity issues of the face, neck and décolleté, ... concept with real potential for the success of ... the ThermiHealth Clinical Advisory Council, ThermiGyn’s Women’s Health ... FACS, ACGE, concluded that ThermiGyn’s temperature controlled radio ...
Breaking Medicine News(10 mins):Health News:A Method to Keep Private Information Secure was Featured on NewsWatch Television 2Health News:Renowned Brain Aneurysm Foundation to Benefit from Arnold, Missouri’s 3rd Annual Brain Aneurysm Walk in Memory of Lissa Anne Been 2Health News:Professional Staff at QS Fencing Company Now Provides Advice on Railings and Gates 2Health News:The Delray Recovery Center Named 2015 Top Workplace 2Health News:Study Demonstrates Efficacy of Temperature Controlled Radiofrequency for Vulvovaginal Laxity 2Health News:Study Demonstrates Efficacy of Temperature Controlled Radiofrequency for Vulvovaginal Laxity 3
... (THURSDAY) 10:00 A.M., WASHINGTON, July 2 Food ... regulation that would require,growers and packers of fruits and ... those products to be traced back to their farm,of ... will reiterate its,call for growers to implement written food ...
... reduces time of anesthesia, number of instruments inserted into canal ... meant to make surgical treatment of ear infections safer and ... , The device, which combines three of the tools used ... promising results in clinical trials. , Each year in the ...
... Advanced Metals Technologies from Los Alamos National Laboratory ... Aluminum as Strong as Steel ... Cars Go On a Nanotechnology Diet, LOS ALAMOS, N.M., July 2 ... and its licensed patented technology. The announcement,came from MHTX,s affiliate Albuquerque factory, ...
... Alicia Keys, As I Am Concert Tour fans donated to Keep A Child ... by Texting ,ALIVE, to ,90999, ... of the first text message donation campaigns in the U.S.,to benefit Keep A ... out of each show to show a clip from her film Alicia in ...
... out of hiding could bring about a cure, scientists say ... are afflicted by breakouts of unsightly cold sores, caused by ... offering them the possibility of a cure. , Scientists at ... simplex 1 slips into dormancy and stays dormant -- evading ...
... Extension of Promotion -, DENVER, July 2 ... functional foods, beverages and nutritional,supplements, announced that "XELR8 ... the $1 million sales goal for the month ... to earn,significant bonuses in July., John Pougnet, ...
Cached Medicine News:Health News:New Ear Tube Device Helps Treat Infections Faster 2Health News:Manhattan Scientifics Acquires Metallicum, Inc. 2Health News:Manhattan Scientifics Acquires Metallicum, Inc. 3Health News:Manhattan Scientifics Acquires Metallicum, Inc. 4Health News:Keep A Child Alive and Alicia Keys Raise $40,000 Through Mobile Donations During U.S. Concert Tour 2Health News:Keep A Child Alive and Alicia Keys Raise $40,000 Through Mobile Donations During U.S. Concert Tour 3Health News:New Hope Against the Cold Sore Virus 2Health News:New Hope Against the Cold Sore Virus 3Health News:XELR8 Holdings Announces Continuation of 'XELR8 To A Million' Promotion 2
(Date:5/1/2015)... NEW YORK , May 1, 2015  Shares ... over 70% of their value yesterday following the results ... company,s glaucoma therapy, Rhopressa.  Despite the trial failing to ... indicates that positive results may come from future studies. ... a brief company overview, current pipeline, financial review, analyst ...
(Date:4/30/2015)... 30, 2015 Omnicell, Inc. (NASDAQ: OMCL ), ... to healthcare systems, today announced results for its first ... Revenue for the first quarter of 2015 was $116.2 ... quarter of 2014, and down $5.3 million or 4.4% ... quarter 2015 net income as reported in accordance with ...
(Date:4/30/2015)... Diabetes Care ® , Inc. (NASDAQ: TNDM ), a ... and t:flex™ Insulin Pumps, today reported its financial results for ... comparing the first quarter of 2015 to the same period ... million from $8.1 million , t:slim Pump shipments grew ... "Our investment in resources to build the foundation of our ...
Breaking Medicine Technology:All is Not Lost for Aerie Pharmaceuticals - VLM Research Issued by BrokerBank Securities, Inc. 2Omnicell Announces First Quarter 2015 Results 2Omnicell Announces First Quarter 2015 Results 3Omnicell Announces First Quarter 2015 Results 4Omnicell Announces First Quarter 2015 Results 5Omnicell Announces First Quarter 2015 Results 6Omnicell Announces First Quarter 2015 Results 7Omnicell Announces First Quarter 2015 Results 8Omnicell Announces First Quarter 2015 Results 9Omnicell Announces First Quarter 2015 Results 10Omnicell Announces First Quarter 2015 Results 11Omnicell Announces First Quarter 2015 Results 12Omnicell Announces First Quarter 2015 Results 13Omnicell Announces First Quarter 2015 Results 14Omnicell Announces First Quarter 2015 Results 15Omnicell Announces First Quarter 2015 Results 16Omnicell Announces First Quarter 2015 Results 17Omnicell Announces First Quarter 2015 Results 18Omnicell Announces First Quarter 2015 Results 19Omnicell Announces First Quarter 2015 Results 20Omnicell Announces First Quarter 2015 Results 21Omnicell Announces First Quarter 2015 Results 22Omnicell Announces First Quarter 2015 Results 23Omnicell Announces First Quarter 2015 Results 24Omnicell Announces First Quarter 2015 Results 25Omnicell Announces First Quarter 2015 Results 26Omnicell Announces First Quarter 2015 Results 27Tandem Diabetes Care Reports First Quarter 2015 Financial Results 2Tandem Diabetes Care Reports First Quarter 2015 Financial Results 3Tandem Diabetes Care Reports First Quarter 2015 Financial Results 4Tandem Diabetes Care Reports First Quarter 2015 Financial Results 5Tandem Diabetes Care Reports First Quarter 2015 Financial Results 6
Sheath Introducers with guidewires....
... The Driver Stent design, utilizing ... the limitations of stainless steel ... possible thinner struts, for unparalleled ... The Driver Coronary Stent Systemwith ...
The complete performance package. Precision handling. Stable platform for device delivery. Enhanced backup support. Unique braid technology. Improved curve retention. Smooth PTFE liner....
The soft tip sheath design for smooth delivery and retrieval of Constellation advanced mapping basket catheters....
Medicine Products: