Navigation Links
Elements In Grape fruit Juice Combine Lethally with Certain Drugs, leading to potentially dangerous side effects, study.

Novel research from the University of North Carolina at Chapel Hill has zeroed in on a substance in grapefruit juice that could cause dangerous side effects when ingested with certain drugs.//

Certain medications administered to patients for control of blood pressure and cholesterol and other drugs if consumed along with grape fruit juice could cause unhealthy and even dangerous side effects.

The drugs affected by grapefruit juice usually have some difficulty entering the body after they are consumed because an intestinal enzyme, CYP3A, partially destroys them, as they are absorbed. Grapefruit juice, but not other commonly consumed fruit juices, inhibits this enzyme, allowing more of these drugs to enter the body.

It was originally assumed that the ingredients responsible for drug interactions were the flavonoids that give grapefruit juice its bitter taste.

The new study shows that a group of chemicals called furanocoumarins are the likely culprit.

'This is the best evidence to date that furanocoumarins are the active ingredients in grapefruit juice that cause the interaction with medications,' said Dr. Paul Watkins, the Dr. Verne S. Caviness distinguished professor of medicine and director of UNC's General Clinical Research Center (GCRC). Watkins led the study team.

A report of the new findings appears in the May issue of the American Journal of Clinical Nutrition.

To determine whether furanocoumarins are responsible for grapefruit juice-drug interactions, Watkins worked with scientists at the Florida Department of Citrus to selectively remove only the furanocoumarins from the juice.

He and his collaborators then studied the effect of the whole juice versus furanocoumarin-free juice on the ability to affect absorption of felodipine, an anti-hypertension drug known to interact with grapefruit juice 'And we found that removing the furanocoumarins from grapefruit juice entirely got rid of t his interaction,' Watkins said. In this randomized study, 18 healthy volunteers took 10 milligrams of felodipine with each of three juices: orange juice, regular grapefruit juice, and grapefruit juice devoid of furanocoumarins. Blood was collected over 24 hours to measure felodipine blood levels. One week elapsed between each felodipine-juice 'treatment.' The study found that in contrast to whole grapefruit juice, the furanocoumarin-free grapefruit juice behaved like orange juice and did not cause an interaction with felodipine.

Watkins notes that there are several implications of this work. 'First, it should now be possible to market the furanocoumarin-free grapefruit juice to patients who would otherwise need to avoid grapefruit. In addition, it should be possible to screen new foods for the potential for drug interactions by determining whether they contain furanocoumarins.

'Finally, it may be possible to add furanocoumarins to formulations of certain drugs that tend to be poorly or erratically absorbed to improve their oral delivery.'

Source:Eureka Alert
'"/>




Related medicine news :

1. Grapes, Melons Implicated in Outbreaks
2. Grape seed extract helps wound healing
3. To Reduce Risk Of Cancer Eat Grapes
4. Grapefruit extract effective in stomach ulcer healing
5. Grape fruit seed extracts can heal stomach ulcers
6. Heart Disease In Women Can Be Reduced By Eating Grapes
7. Compound In Grapes And Red Wine To Counter Alzheimers Disease
8. Gum disease is beatable by Grapefruit
9. Grapefruit Aroma Makes Women Appear Younger
10. One fruit that has captured the health benefit sector is Grapefruit!
11. High Blood Pressure Can Be Treated With Grape Seed Extract
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/6/2016)... Maryland (PRWEB) , ... December 06, 2016 , ... ... announced the launch of a Kickstarter crowd funding campaign ( http://kck.st/2g3a1so ) for ... health active alerts and even taking an EKG from the watch while sharing ...
(Date:12/6/2016)... ... December 06, 2016 , ... 'Tis the season for ... routines. That means it's also the season when eating healthy, staying active, and taking ... on schedule is harder to do. , "Shopping trips, parties and family gatherings ...
(Date:12/6/2016)... ... December 06, 2016 , ... “Tatiana Sibirskaya: A Life Devoted ... of sacrifice and enlightenment. , “Tatiana Sibirskaya: A Life Devoted to ... for creative outlets, Carolyn gravitated toward writing through the inspiration of her aging ...
(Date:12/6/2016)... ... December 06, 2016 , ... TopConsumerReviews.com recently gave a best-in-class ... . , Mobility Scooters give freedom to people who need help getting around. For ... be facing a long period of rehabilitation after an illness or accident. There is ...
(Date:12/6/2016)... ... 06, 2016 , ... "Add realistic flares and light leaks to your media ... to clip with high quality 4K lens flare footage," said Christina Austin - CEO ... filmed on the RED Dragon. Utilizing the Dragon Sensor, TransFlare 4K Jewel lens flare ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... PARSIPPANY, N.J. , Dec. 5, ... Sankyo) today announced preliminary safety and efficacy data ... investigational oral selective MDM2 inhibitor, suggesting that DS-3032 ... including relapsed/refractory acute myeloid leukemia (AML) and high-risk ... escalation part of the phase 1 study of DS-3032 ...
(Date:12/5/2016)... -- BD (Becton, Dickinson and Company) (NYSE: BDX ... an enhanced technology platform designed with the ability to ... Pyxis™ and Alaris™ systems, at this year,s American ... being held in Las Vegas ... that approximately 68 percent of medication errors occur during ...
(Date:12/5/2016)... Eisai Inc. announced today new analyses and ... of the American Epilepsy Society (AES). ... adjunctive therapy for the treatment of partial onset seizures ... generalized tonic-clonic seizures (PGTC) in patients with epilepsy who ... Important Safety Information for FYCOMPA, including Boxed WARNING for ...
Breaking Medicine Technology: