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Effects of 'starvation Hormone'-Newly Identified in Low-carb Diets

eight on the special diet, turned up FGF21.'We saw a dramatic increase in FGF21 in the livers of the mice [on the diet],' she said.

Kliewers group showed that FGF21 is induced directly by PPAR (peroxisome proliferator-activated receptor) in liver in response to fasting in mice. Scientists have known that PPAR controls fats use as an energy source during starvation. In addition, some drugs that lower 'bad' cholesterol work by targeting PPAR. FGF21 in turn stimulates lipid breakdown in white adipose tissue and ketone body production in the liver. They unexpectedly also found that FGF21 led the animals to reduce their physical activity and made them more sensitive to entering torpor, a short-term, hibernation-like state.

'During fasting, the liver hormone communicates with adipose tissue to send fat to the liver. It turns on the metabolism of fat into ketone bodiesand at the same time, it sensitizes the animals to going into torpor to conserve energy. Its clear that FGF21 is a principal component of the fasting.' she added.


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TAG: Effects starvation Hormone Newly Identified Low carb Diets

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