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Effective Vaccine for Leishmaniasis in the Pipeline

drawback with carbohydrate vaccines is the difficulty in getting them to produce a strong immune response. Vaccine manufacturers achieve this by adding a booster substance called adjuvant. Seeberger’s vaccine against leishmaniasis combines the delivery vehicle, immune-stimulating antigen and adjuvant into one package.

The delivery vehicle is an influenza virosome that is an empty envelope of the influenza virus. They contain none of the infectious genetic material of the flu viruses. The virosome also acts as an adjuvant, boosting the immune response of the vaccine. The antigen is a synthetic carbohydrate similar to substances on the surface of the leishmaniasis bacteria. Seeberger’s group is planning to test the vaccine on animals. WHO assigned a high priority to development of a leishmaniasis vaccine because of the huge human toll and the lack of any effective treatment.

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