Navigation Links
Effective Vaccine for Leishmaniasis in the Pipeline

Leishmaniasis is a parasitic disease that kills about 60,000 people annually. It spreads by the bite of infected female sand flies. // Visceral leishmaniasis infects about 500,000 people annually mainly in India, Bangladesh, Nepal, Sudan and Brazil. The most common drugs to treat leishmaniasis have serious side effects and are expensive. Symptoms of visceral leishmaniasis include fever, weight loss, and abnormalities of the liver and spleen. As there is no effective vaccine for the visceral, or internal, form of leishmaniasis till date there is an increase in the death rate due to the disease. Peter H. Seeberger, Ph.D., of the Laboratory for Organic Chemistry at the Swiss Federal Institute of Technology (ETH) in Zurich developed a fundamentally new vaccine for the disease. The research team consisted of scientists from the Swiss Tropical Institute in Basel and Pevion Inc., a biotech company focusing on virosomal delivery systems.

The results of the research findings were reported in ACS Chemical Biology, one of 34 peer-reviewed journals published by the American Chemical Society, the world’s largest scientific society. Several leishmaniasis candidate vaccines are in various stages of development. The vaccine is a new genre of carbohydrate-based vaccines. Carbohydrates are chemical compounds that include sugar which are linked together. The vaccine is not only useful in humans but can be used to protect pets (dogs) against leishmaniasis. Carbohydrate vaccines are used in everyday medicine, including vaccines to immunize against meningitis and other bacterial infections, mainly in small children in the United States. Those vaccines use carbohydrates isolated from the actual bacteria responsible for the diseases.

The carbohydrates act as antigens, which stimulate the immune system to produce antibodies. But now synthetic carbohydrates are used as antigens in order to control the purity and composition and avoid possible contamination. But one major drawback with carbohydrate vaccines is the difficulty in getting them to produce a strong immune response. Vaccine manufacturers achieve this by adding a booster substance called adjuvant. Seeberger’s vaccine against leishmaniasis combines the delivery vehicle, immune-stimulating antigen and adjuvant into one package.

The delivery vehicle is an influenza virosome that is an empty envelope of the influenza virus. They contain none of the infectious genetic material of the flu viruses. The virosome also acts as an adjuvant, boosting the immune response of the vaccine. The antigen is a synthetic carbohydrate similar to substances on the surface of the leishmaniasis bacteria. Seeberger’s group is planning to test the vaccine on animals. WHO assigned a high priority to development of a leishmaniasis vaccine because of the huge human toll and the lack of any effective treatment.

'"/>




Related medicine news :

1. New Way to "See" Genes, Evaluate Effectiveness of Gene Therapies Discovered
2. Inhaled Steroids Safe & Effective for Children with Asthma
3. ZD1839 Proves Effective - A Breakthrough in fighting Lung Cancer
4. Fluoride Found Effective in Osteoporosis
5. Aspirin and Warfarin Are Equally Effective for Stroke Prevention
6. Implantable Contact Lens Found Safe and Effective
7. Effective And Economical Agent For Anthrax
8. Stem Cell Transplants May Be Effective For MS Patients
9. Effective therapy for Huntingtons disease
10. Chemotherapy Effective for Bladder Cancer
11. Drug Effective for Vascular Dementia
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2017)... Fla. (PRWEB) , ... March 27, 2017 , ... ... overdose deaths soared 167%,(1) with opioids alone responsible for over 33,000 of the ... McCarty has sponsored Assembly Bill (AB) 1512, which proposes a tax on prescription ...
(Date:3/25/2017)... ... ... Norland at Swissray is pleased to announce the release of the ELITE DXA, ... has an active scan window, which is more than double that of existing bone densitometers. ... could not undergo an accurate total body bone density or body composition study. ...
(Date:3/24/2017)... Greenville, SC (PRWEB) , ... March 24, 2017 , ... ... , is excited to announce the opening of a Greenville, South Carolina ... center for digital progress in Greenville. , “We’ve been working with South Carolina clients ...
(Date:3/24/2017)... , ... March 24, 2017 , ... ... planning, and related services to families and business owners across eastern Michigan, is ... feeding regional families struggling with financial difficulties. , The Oxford/Orion FISH Food Pantry ...
(Date:3/24/2017)... CA (PRWEB) , ... March 24, 2017 , ... ... on two panels at the Advanced ERISA Benefit Claims Litigation seminar in Chicago, ... Creating the Administrative Record, The majority of cases litigated under ERISA involve claims ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... Research and Markets has announced the addition of the "Global Wound ... report to their offering. ... The global wound care market was worth $24,482.9 million in 2015 and ... Among the various wound care products type, the advanced wound ... 2015. Among the various applications, surgical wound segment held the largest share ...
(Date:3/24/2017)... 2017   The Accreditation Council for Medical ... in the pharmaceutical industry has appointed Dr. ... newly formed scientific advisory board. Dr. Chin will ... first ever medical affairs think tank within the ... the ACMA, please visit  www.medicalaffairsspecialist.org .  Connect ...
(Date:3/24/2017)... , March 24, 2017 FinancialBuzz.com News Commentary ... Medical cannabis products around ... Research, Inc., projects that the global medical cannabis market will reach a ... is a major market for the new growing industry. By the ... to legally buy and sell medical cannabis. More conservative states like ...
Breaking Medicine Technology: