Navigation Links
Effective Anti - Psychotic Drugs Pack Health Risk

According to a study of its first kind, close monitoring of patients who have taken antipsychotic drug – clozapine uncovered physical health risks// associated with it.

Rochester researchers have found that clozapine, the effective anti-psychotic drug showed serious health consequences related with higher risk for metabolic syndrome in long-term users.

Metabolic syndrome is a group of conditions that increase the risk for heart disease, stroke and diabetes. The conditions include high blood pressure, excess body fat around the waist, abnormal levels of cholesterol and triglycerides and insulin resistance. Any one of the conditions increases the risk of serious disease. In combination, the risk grows greater.

More than half the clozapine patients studied had metabolic syndrome while only about 20 percent of those in a comparison group did, researchers report in the July issue of The American Journal of Psychiatry.

Patients with metabolic syndrome in this study would be expected to have a two-to-threefold increase in cardiovascular disease mortality, the Medical Center Department of Psychiatry researchers state. ‘Clozapine is the last hope for many people,’ said J. Steven Lamberti, M.D., associate professor of psychiatry and lead author of the journal article. ‘But there are long-term health implications. This study suggests that patients who need the most effective medication are between a rock and a hard place.’

The increased physical health risks must be balanced with the potential benefits of clozapine, the researchers conclude. In addition to its superior efficacy for patients resistant to conventional antipsychotic drugs, clozapine also is the only medication currently approved by the Food and Drug Administration for the treatment of suicidal behavior.

Physicians should monitor closely people who receive clozapine with regular tests for glucose and blood lipid levels, blood pressure and body weight, L amberti said.

‘We need to raise the awareness of physicians about this issue so they monitor their patients and intervene promptly when required to prevent long-term adverse health consequences,’ Lamberti said.

Lamberti and his fellow researchers studied 93 patients at the Medical Center's Department of Psychiatry who had been receiving clozapine for at least six months. The patients were weighed, measured and tested for diabetes, blood lipids and blood pressure. The researchers then compared the patients to a group of about 2,700 individuals from a national database of health information for thousands of Americans. The comparison group was matched for age, body mass, and race or ethnicity.

The researchers found that 53.8 percent of the clozapine patients had metabolic syndrome. But only 20.7 percent of the comparison group had the same syndrome.

Many studies have shown that clozapine is associated with weight gain, but this is the first study to describe clozapine's link to metabolic syndrome.

‘People with schizophrenia are known to exercise less and have poor diets,’ Lamberti said. ‘Those factors contribute to metabolic syndrome. We can't say how much clozapine contributes to metabolic syndrome, but we have shown the high prevalence of the syndrome in those who take clozapine.’

The National Institutes of Health initiated the Clinical Antipsychotic Trials for Intervention Effectiveness investigation to determine the comparative effectiveness of several drugs.

In one major study, the investigators compared clozapine to new antipsychotic drugs in a group of patients that had not improved with the new drugs. In April, the investigators reported that clozapine was significantly more effective than the new medications. Patients receiving clozapine were less likely to discontinue treatment than those on other drugs.

Because of the findings of this NIH-sponsored study, Lamberti expects a surge in the use of clozapine, a drug he said has been underutilized.

‘With any increased use of clozapine, it becomes even more important to point out the need to closely monitor and treat patients who take the drug for metabolic syndrome and its consequences,’ Lamberti said.

Source:Eurekalert
'"/>




Related medicine news :

1. New Way to "See" Genes, Evaluate Effectiveness of Gene Therapies Discovered
2. Inhaled Steroids Safe & Effective for Children with Asthma
3. ZD1839 Proves Effective - A Breakthrough in fighting Lung Cancer
4. Fluoride Found Effective in Osteoporosis
5. Aspirin and Warfarin Are Equally Effective for Stroke Prevention
6. Implantable Contact Lens Found Safe and Effective
7. Effective And Economical Agent For Anthrax
8. Stem Cell Transplants May Be Effective For MS Patients
9. Effective therapy for Huntingtons disease
10. Chemotherapy Effective for Bladder Cancer
11. Drug Effective for Vascular Dementia
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/22/2017)... Carolina (PRWEB) , ... August 22, 2017 , ... ... advisor. Mr. Stewart is the Founder and Managing Member for t4 Leadership Development ... have become critical to his definition of “success”: physician leadership development, servant leadership, ...
(Date:8/22/2017)... ... August 22, 2017 , ... Although Labor Day is ... many communities have begun providing weekend displays, and numerous households celebrate the unofficial end ... can be downright terrifying for pets. , Kris Zambo, owner of Dynamite ...
(Date:8/21/2017)... ... August 22, 2017 , ... ... Stevens as a 2017-2018 inductee into its VIP Woman of the Year ... is the nation’s leading networking organization exclusively for professional women, boasting more than ...
(Date:8/21/2017)... ... August 21, 2017 , ... SportsEngine, Inc. , ... Official Technology Partner of North Country Region Volleyball and will power registration, scheduling, ... along with providing sport management software to their member clubs. , ...
(Date:8/21/2017)... ... August 21, 2017 , ... Duncan Insurance ... serving the people of Michigan. The new initiative fundraises for the Kalamazoo Humane ... very forefront of animal protection and welfare by addressing the root causes of ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)...  Diplomat Pharmacy, Inc. (NYSE: DPLO), the nation,s largest independent ... 30, 2017.  All comparisons, unless otherwise noted, are to the ... Second Quarter 2017 Highlights include: ... increase of 3.5% Total prescriptions dispensed of ... 7.5% versus 7.6% Gross profit per ...
(Date:8/3/2017)... DIEGO , Aug. 3, 2017  Opioid addiction ... diseases driving up healthcare costs and threatening outcomes, were ... lab supply and IVD industry that support them, met ... care market researcher said that drugs of abuse, procalcitonin ... and sessions at the organization,s 69th meeting in ...
(Date:8/2/2017)... , Aug. 2, 2017 CaryRx, a next-generation full-service ... delivery service for patients in the Washington D.C. ... retail pharmacy by providing delivery of medications through the convenience ... future delivery or delivered within one hour to any location ... excited to bring this invaluable service to Washington ...
Breaking Medicine Technology: