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Effect of ADHD Drugs on the Brain - Study Finds

Investigating on the target areas, where ADHD drugs act, researchers have concluded that it primarily targets the prefrontal cortex (PFC) region of the brain //rather than on accumbens and medial septum regions.

Researchers at the University of Wisconsin-Madison found how the drug Ritalin used in treating the symptoms of attention deficit hyperactivity disorder (ADHD), works in the brain.

But new work at the University of Wisconsin-Madison is now starting to clear up some of the mystery. Writing in the journal Biological Psychiatry, UW-Madison researchers report that ADHD drugs primarily target the prefrontal cortex (PFC), a region of the brain that is associated with attention, decision-making and an individual's expression of personality.

The finding could prove invaluable in the search for new ADHD treatments, and comes amidst deep public concern over the widespread abuse of existing ADHD medicines.

'There's been a lot of concern over giving a potentially addictive drug to a child [with ADHD],' says lead author Craig Berridge, a UW-Madison professor of psychology. ‘But in order to come up with a better drug we must first know what the existing drugs do.'

A behavioral disorder that afflicts both children and adults, ADHD is marked by hyperactivity, impulsivity and an inability to concentrate. The National Institute of Mental Health estimates that 2 million children in the U.S. suffer from the condition, with between 30 to 70 percent of them continuing to exhibit symptoms in their adult years.

Despite public anxiety over the treatment of a behavioral condition with pharmacological drugs, doctors have continued to prescribe meds like Adderall, Ritalin and Dexedrine because - quite simply - they work better than anything else.

ADHD drugs fall into a class of medications known as stimulants. ADHD stimulants boost levels of two neurotransmitters, or chemical messengers in the brain, known as dopa
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