Navigation Links
Eczema patients lack natural antibiotic in skin

Researchers at National Jewish Medical and Research Center report in the New England Journal of Medicine that patients with atopic dermatitis, also known as eczema, are susceptible to bacterial infections// of their skin because they fail to produce effective amounts of two antimicrobial peptides. The findings demonstrate the clinical significance of these peptides in humans, and suggest that a medication containing or inducing the peptides may one day be used to fight the infections that plague millions of atopic dermatitis patients.

"This study helps explain why 90 percent of atopic dermatitis patients are colonized by staphylococcus aureus and 30 percent develop active infections," said the study’s senior author, Donal Leung, Head of Pediatric Allergy-Immunology at National Jewish Medical and Research Center, in Denver. "It is important to understand why people with this common skin disease are so susceptible to skin infections especially in light of recent widespread concerns that they can develop severe infections after receiving a smallpox vaccination. Interestingly, these antimicrobial peptides are also needed to combat viral infections and therefore could account for the susceptibility of atopic dermatitis patients to eczema vaccinatum and herpes simplex infections."

Atopic dermatitis is a common, chronic skin disease characterized by dry, itchy and easily irritated skin. It occurs most commonly in infants and young children, but can persist into adulthood. Severe cases can lead to sleep deprivation, chronic bacterial infections, and depression. Approximately one in nine people in the United States suffer from this diseases at some point. Along with other allergic diseases, its prevalence has grown significantly in recent years.

Immunologists recently identified peptides in the skin that help fight incipient infections. They rarely appear in normal skin, but are produced in reaction to skin inflammation. Since atopic dermati tis patients are so frequently plagued by bacterial infections, Dr. Leung and his colleagues decided to investigate the potential role of the antimicrobial peptides in those patients.

They evaluated the levels of two antimicrobial peptides, known as LL-37 and HBD-2, in eight patients with moderate to severe atopic dermatitis, 11 psoriasis patients, and six healthy individuals. Psoriasis is an inflammatory skin disease, whose patients rarely suffer skin infections. Microscopic examination of skin samples showed significant amounts of the peptides in the skin of psoriasis patients, but none to minor amounts in skin from atopic dermatitis patients, and none in the skin of healthy controls. Additional analysis indicated that most psoriasis patients had at least 10 times as much of the peptides in their skin as did atopic dermatitis patients. Many atopic dermatitis patients had no detectable amounts of the antimicrobial peptides in their skin.

When the researchers treated staphylococcus aureus colonies with the antimicrobial peptides, levels found in skin of psoriasis patients killed the bacterial. The researchers also found that two hormone-like proteins associated with the immune response and commonly secreted by atopic dermatitis patients’ cells. "These findings indicate that atopic dermatitis patients have an impaired immune response that prevents them from producing adequate amounts of antimicrobial peptides in their skin," said Dr. Leung.

'"/>




Related medicine news :

1. Immunosupressants for Eczema
2. FDA Approves Elidel Cream for Eczema
3. New Treatment for Chronic Eczema
4. Home-based Treatment For Eczema More Effective Compared To Hospital Care
5. Vitamin C Consumption In Pregnancy Found To Increase The Likelihood Of Asthma and Eczema in Kids
6. Azathioprine Can Soon Revolutionize Eczema Treatment
7. Azathioprine to Treat Eczema?
8. Children Having An Early Exposure To Cats May Develop Eczema
9. Eczema And Hay Fever Decline In UK While Allergic Reactions On The Rise
10. Now Single Jab Could Ward off Asthma, Eczema and Hay Fever
11. Hydrolysed Casein Formula may Slash Eczema in Infants
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/17/2017)... ... February 17, 2017 , ... ... its educational assistance management solution to the exhibit floor for the 2017 ... Fla. , From Feb. 19–23, 2017, more than 40,000 healthcare industry professionals ...
(Date:2/17/2017)... Verdes, CA (PRWEB) , ... February 17, 2017 ... ... emotional flow is Dr. Carol Francis' goals for each and every ... Conference, Dr. Carol Francis will demonstrate five different brainwave tools which help energize ...
(Date:2/17/2017)... ... February 17, 2017 , ... Qualis ... a finalist in the 8th Annual DecisionHealth Platinum Awards in recognition of its ... Health’s work is recognized across multiple award categories, highlighting four of the organization’s ...
(Date:2/17/2017)... , ... February 17, 2017 , ... ... fall 2017 season , Trinity Health and the U.S. Soccer Foundation announced today ... program in underserved communities. Soccer for Success, the Foundation’s soccer mentoring program, teaches ...
(Date:2/17/2017)... (PRWEB) , ... February 17, 2017 , ... ... clinical operations executives and focusing on all facets of clinical trial planning and ... management , patient engagement, and more. In addition, attendees stopping by Pharmica’s booth ...
Breaking Medicine News(10 mins):
(Date:2/16/2017)... LOUIS , Feb. 16, 2017  Express Scripts (NASDAQ: ... of the World,s Most Admired Companies within the Health Care: Pharmacy ... be named one of the World,s Most Admired Companies," said ... driven by the commitment and passion of our 26,000 employees to ... we serve." ...
(Date:2/16/2017)... , Feb. 16, 2017  Prescription pain medications ... department visit are necessary for long-term opioid use to ... Feb. 16 th edition of The New ... "Emergency physicians see more patients in acute pain than ... Parker , MD, FACEP, president of the American College ...
(Date:2/16/2017)... 16, 2017   Spectralink Corporation , the ... healthcare, retail, manufacturing and hospitality industries, today announced ... and symbology support features of its PIVOT™:SC ... scanner. The study, conducted by The Tolly Group, ... two phones with dedicated hardware scanners. ...
Breaking Medicine Technology: