Navigation Links
Early Treatment May Thwart Mad Cow-Type Disease

A number of brain diseases caused by mutant prion proteins, such as mad cow disease or scrapie in sheep, //might be averted if normal prion proteins can be depleted, researchers report.

Prion disease, which includes the human form of mad cow disease called variant Creutzfeldt-Jakob disease, is thought to be caused when prion protein in the brain becomes misfolded, and this causes normal prion protein to follow suit. The accumulation of mutant prions is toxic to brain cells, eventually turning the brain to mush.

Now UK researchers report that in mice that have been infected with disease-related prions, early depletion of naturally occurring normal prion protein in neurons leads to repair of sponge-like brain damage.

Their mouse experiments showed that cognitive and behavioral deficits and impaired nerve function accompany early brain damage. "Remarkably, these behavioral and synaptic impairments recover when (normal prion protein) is depleted, in parallel with reversal of spongiosis," the team reports.

"These data now lead to the hope that early intervention in human prion disease will not only halt clinical progression but allow reversal of early behavioral and cognitive abnormalities," Dr. Giovanna R. Mallucci from the Institute of Neurology in London and colleagues write in the journal Neuron.

"Currently, no treatment can prevent the cognitive and motor deficits associated with widespread neurodegeneration in prion disease," they point out.

Mallucci and colleagues do point out that the idea of eliminating normal prion protein "remains somewhat controversial…as the physiological role of the native protein is still unclear." They note, however, that normal prion depletion itself had no effect on behavior and cognition in uninfected animals in the current study.

Source-Bio-Bio Technology
'"/>




Page: 1

Related medicine news :

1. Early detection of prostate cancer
2. Early detection of heart attack
3. Early puberty linked to nutrition
4. Early Clue to Down Syndrome
5. Early delivery can prevent cancer
6. Early puberty more resistance
7. Early menopause- The cause
8. Early menopause- The cause
9. Early Warning System For Breast Cancer
10. Early therapy aids eyesight
11. Early detection of colorectal cancer may be hindered by coloured toilet disinfectants
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/8/2016)... ... 08, 2016 , ... Eating disorders and post-traumatic stress disorder ... and men with eating disorders report a history of trauma, research suggests that ... an eating disorder. , At the 2016 iaedp Symposium, the workshop, “What ...
(Date:2/8/2016)... ... 08, 2016 , ... The Association of Home Care Coding ... Home Health and Hospice ICD-10 Transition Workgroup are working closely with the American ... clarifications, to address concerns over the use of 'A' as the seventh character ...
(Date:2/8/2016)... ... February 08, 2016 , ... The schedule is now online ... AutismOne 2016 Conference, which is being held May 25-29 at the Loews Chicago O’Hare ... helpful interventions and causes of chronic illness in children. , Very recent articles have ...
(Date:2/7/2016)... ... February 07, 2016 , ... HealthSmart ... employers and organizations with the tools and information to lower the costs, and ... cut the cost of providing employee healthcare benefits by as much as 22%:, ...
(Date:2/6/2016)... Viejo, CA (PRWEB) , ... February 06, 2016 , ... ... quickly and easily add warm color grades to their footage. A LUT is a ... every pixel's color to the corresponding color indicated by the table. By manipulating each ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... Feb. 8, 2016  A research team led by ... discovered details of how the abnormal breakage and rearrangement ... aggressive form of acute lymphoblastic leukemia (ALL). Such leukemias ... mutations trigger overproduction of immature cells, called lymphoblasts. ... of the malfunction underlying the type called "Ph-like ALL" ...
(Date:2/8/2016)... SAN DIEGO , Feb. 8, 2016 /PRNewswire/--  ... have announced that advanced tissue-engineering services are now ... using a groundbreaking new three-dimensional (3D) bioprinting approach ... Regenova® 3D Bio Printer , a state-of-the-art robotic ... Applications has created a powerful pay-for-service bio-printing model ...
(Date:2/8/2016)... 2016 http://www.researchandmarkets.com/research/bcrl3s/labelfree ... "Label-Free Detection Market by Technology, Products, ... report to their offering. --> ... the "Label-Free Detection Market by Technology, ... report to their offering. --> ...
Breaking Medicine Technology: