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Early Estrogen Therapy May Reduce Cardiovascular Risks

he Departments of Obstetrics, Gynecology & Reproductive Sciences and Molecular Cellular & Developmental Biology. “It is important not to trivialize quality of life. No one should tell women to put up with hot flashes to avoid serious risk, if in reality this therapy saves lives.”

The KEEPS will also examine whether the natural human estrogen, estradiol, delivered through the skin via a patch is equally effective as, and potentially safer than, oral estrogen. Researchers have speculated that this method may be safer since transdermal estrogen does not go to the liver in high concentrations and has been shown to have little or no effect on clotting disease.

“The WHI was instrumental in providing a roadmap for the next phase of research to examine whether estrogen protects younger women from cardiovascular disease, as earlier observational studies indicated, said Harman. “KEEPS is designed to provide useful new data to begin answering women’s questions and help shape future research.”

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