Navigation Links
Early Estrogen Therapy May Reduce Cardiovascular Risks

A new analysis of both estrogen and estrogen plus progestin shows a 24 percent reduction in risk for coronary heart disease events in women starting// hormone therapy less than 10 years after menopause.

The analysis, by researchers at Yale and eight other study centers participating in the Kronos Early Estrogen Prevention Study (KEEPS), also showed a 30 percent reduction in overall deaths among women aged 50 to 59 using hormone therapy.

However, the new study, “Postmenopausal Hormone Therapy and Risk of Cardiovascular Disease by Age and Years Since Menopause,” also found that hormone therapy increased coronary heart disease events by 28 percent in older women, and that deaths increased by 14 percent in women aged 70 to 79. There was a slightly elevated risk of stroke at all ages studied.

The Women’s Health Initiative was halted in July 2002 due to overall elevated risks. This new analysis indicates that excess cardiovascular risk is confined to older women, which is consistent with previous research. Prior to the WHI, most data suggested that hormone therapy was associated with a high degree of protection (30 to 50 percent reductions) against coronary heart disease, all-cause mortality, and osteoporotic fractures, in addition to a small increase in breast cancer risk.

“This new analysis of WHI data seems to confirm earlier findings that estrogen may be good early, but bad late,” said Dr. S. Mitchell Harman, director of the Kronos Longevity Research Institute. The Institute is conducting the KEEPS, a randomized, controlled, double-blinded trial of 720 women designed to provide prospective data on the risks and benefits of early menopausal hormone therapy, particularly as it relates to the progression of atherosclerosis.

“In this study, hormone therapy reduced overall mortality in the younger menopausal women,” said lead investigator of the KEEPS trial at Yale, Hugh S. Taylor, M.D., associate professor in t he Departments of Obstetrics, Gynecology & Reproductive Sciences and Molecular Cellular & Developmental Biology. “It is important not to trivialize quality of life. No one should tell women to put up with hot flashes to avoid serious risk, if in reality this therapy saves lives.”

The KEEPS will also examine whether the natural human estrogen, estradiol, delivered through the skin via a patch is equally effective as, and potentially safer than, oral estrogen. Researchers have speculated that this method may be safer since transdermal estrogen does not go to the liver in high concentrations and has been shown to have little or no effect on clotting disease.

“The WHI was instrumental in providing a roadmap for the next phase of research to examine whether estrogen protects younger women from cardiovascular disease, as earlier observational studies indicated, said Harman. “KEEPS is designed to provide useful new data to begin answering women’s questions and help shape future research.”

Source-YALE Universty
SRM/B
'"/>




Related medicine news :

1. Early detection of prostate cancer
2. Early detection of heart attack
3. Early puberty linked to nutrition
4. Early Clue to Down Syndrome
5. Early delivery can prevent cancer
6. Early puberty more resistance
7. Early menopause- The cause
8. Early menopause- The cause
9. Early Warning System For Breast Cancer
10. Early therapy aids eyesight
11. Early detection of colorectal cancer may be hindered by coloured toilet disinfectants
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/23/2017)... ... (PRWEB) February 23, 2017 ... nation to come together to combine its favorite springtime pastime ... favorite fruit – apples! To celebrate National Nutrition Month, the ... “Apple Madness” bracket tournament – a five-week, five-round online competition ...
(Date:2/23/2017)... ... February 23, 2017 , ... Curemark, LLC announced today ... efficacy of CM-AT in children aged 3-8 with Autism, is now enrolling at three ... enrolling children across the United States. , “There are currently no approved drugs ...
(Date:2/23/2017)... ... ... Carlos Gutierrez has lived his spiritual life hardly without ... the purpose of everyone in this universe. As Gutierrez sees the need of spiritual ... to guide readers to expand one’s spiritual life. , “Our Spiritual Truths” deals with ...
(Date:2/22/2017)... ... 22, 2017 , ... Gevir, a New Zealand-based company that focuses on developing ... coming soon to Amazon.com, the world’s largest online retailer. , The company ... an effective natural treatment for Shelley’s Multiple Sclerosis, which she’d been diagnosed with at ...
(Date:2/22/2017)... ... February 22, 2017 , ... Secure Exchange Solutions, the ... network of hospitals, health information exchanges, physicians and patients, announced today that SES ... 2015 Edition Health IT Module Certification via Drummond Group LLC, an Authorized Certification ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... The U.S. cannabis market is growing rapidly as ... 2016. According to a new report published by New Frontier ... billion in 2016 and is projected to grow at a ... are projected to jump from $2.6 billion in 2016 to ... may grow faster as the estimate was based on the ...
(Date:2/23/2017)... KNOXVILLE, Tenn. , Feb. 23, 2017 ... or the "Company"), a clinical-stage oncology and dermatology biopharmaceutical ... Horowitz and Dominic Rodrigues as special ... and Mr. Rodrigues will advise the board on financial ... it had received an investment commitment of up to ...
(Date:2/23/2017)... 22, 2017 Orthopedic and cardiac devices ... aging demographic patterns lead to an increasing prevalence ... and exercise-related injuries, chronic back problems, heart valve ... gains. The future of medical implants faces many ... questions and more: - What types of ...
Breaking Medicine Technology: