Navigation Links
Eap1 in the Brain Regulates the Female Reproductive Cycle

The onset of puberty and maintenance of the female reproductive cycle are events controlled by neurons in the hypothalamus that secrete gonadotropin-releasing hormone (GnRH). How signaling to these neurons is controlled remains unclear.

In a study appearing online on July 12 in advance of publication in the August print issue of the Journal of Clinical Investigation, Sergio Ojeda and colleagues from Oregon Health & Science University report that the gene enhanced at puberty 1 (EPA1) acts as a regulator of the neuronal signaling that controls female reproductive function.

The authors found that EPA1 expression was selectively increased at puberty in the hypothalamus in monkeys, rats, and mice. They also showed that the protein product of EPA1 was expressed in neurons involved in the control of reproduction, and that EAP1 activated GnRH.

The authors went on to show that inhibition of EPA1 expression in the rat hypothalamus delayed the onset of puberty and disrupted estrous in these animals. The data suggest that EPA1 is an important regulator acting within the brain and contributes to the control of female reproductive function.

AUTHOR CONTACT: Sergio R. Ojeda Oregon Health & Science University, Beaverton, Oregon, USA. Phone : (503) 690-5302; Fax: (503) 590-5384; E-mail: ojedas@ohsu.edu


'"/>




Page: 1

Related medicine news :

1. Use of Cellular Phones associated with Increased risk of Brain Tumors
2. Brain death – How to cope with it
3. “Brain fingerprinting”- The new lie detectr
4. Nasal Spray Could Take Drugs Direct to Brain.
5. Virus Combats Brain Tumour
6. Nasal Spray Could Take Drugs Directly to Brain
7. Control of anger disorder connected to Brain Dysfunction
8. High Levels of Protein Linked to Brain Shrinkage
9. Brain damage affects artistic skill
10. Brain cells protected by new compounds
11. Brain changes observed in people with sleep apnoea
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... ... March 24, 2017 , ... Digital Scientists, a software ... announce the opening of a Greenville, South Carolina location. The lab has ... in Greenville. , “We’ve been working with South Carolina clients for years from our ...
(Date:3/24/2017)... ... March 24, 2017 , ... According to a new ... invalid because it does not obey the rules Congress has directed the CBO to ... which the GOP reform would restore. Yet, it estimates a reduction in employer-based coverage ...
(Date:3/24/2017)... , ... March 24, 2017 , ... The iaedp Foundation, ... other medical professionals caring for those suffering from the full spectrum of disordered eating, ... as eating disorders professionals from nearly all 50 states and several countries converged on ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... Arizona’s Premier Center for Shamanic Healing and Spiritual Awakening, proudly presents her ... 9--24, 2017. This sacred and spiritual journey during the Summer Solstice will ...
(Date:3/24/2017)... ... March 24, 2017 , ... As the standards ... a communications platform that positions them as the go-to thought leader in all ... online publication as an always-on, always-fresh news, views and advocacy engine, called ONS ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... March 27, 2017 Cota Healthcare, ... value-based precision medicine, today announced the signing ... Pharmaceuticals Corporation to help improve clinical and ... As part of this agreement, which ... entered into January 2016, teams from across ...
(Date:3/27/2017)... HAMILTON, N.J. , March 27, 2017 ... company and leading in vivo pharmacology contract ... Solar Farm adjacent to its newly expanded preclinical research ... The solar farm provides a cleaner, renewable energy source ... on the environment. Completion of the Genesis Solar Farm ...
(Date:3/24/2017)... LEBANON, N.H. , March 24, 2017 ... as the recipient of an award including funding and ... free blood draw technology.  "Making blood ... way to making their whole hospital experience better.  We,re ... how this technology can help improve care for the ...
Breaking Medicine Technology: