Navigation Links
EBV Might Trigger Multiple Sclerosis, Study

ed by antigens,' said Edwards.

'We also examined T-cell responses to influenza hemagglutinin, antigens derived from cytomegalovirus, and even EBV antigens other than EBNA1,' Edwards said. 'The T-cell responses to these were all normal in MS patients, indicating a distinct role for EBNA1 in the disorder.'

The team then wanted to determine which portion of EBNA1 the T cells were recognizing. Generally, immune cells recognize one small, specific part on a protein, called an immunodominant region. Earlier evidence had pointed to one end of the protein, so the team decided to focus there. Münz supplied a series of 51 peptides—small segments of the EBNA1 protein—that the team added to T cells from MS patients and healthy controls.

As expected, the T cells in the healthy volunteers activated only in the presence of a specific group of peptides. But, Edwards said, 'EBNA1-specific T cells from the MS patients not only increased in frequency, but also recognized a much broader region of the protein, compared to healthy people who carried the EBV virus.' Immunologists call this phenomenon epitope-spreading. 'This was an interesting and unexpected finding,' said Edwards. 'At this point, I really believed we had a story.’

Finally, the team discovered that the hyper-reactive T cells belonged to the CD4 compartment of memory T cells and that these cells were strong producers of interferon-gamma, an anti-viral protein that shapes immune responses. 'Animal research has shown that pro-inflammatory CD4 cells directed against central nervous system antigens can trigger an MS-like disease,' said Edwards. 'So we knew we were looking at the right population of T cells.'

The next step will be to determine how these over-reactive immune cells trigger the destruction of the myelin sheathing that insulates nerve cells. 'The broadened response of the T cells could lead them to recognize and attack cells they aren't supposed to, like b
'"/>




Page: 1 2 3 4

Related medicine news :

1. Anemia Treatment for Cancer Patients Might Not be a Good Idea.
2. Tomatoes Might Inhibit the Development Of Prostate Cancer
3. Mad Cow Disease Might Be Linked to Blood Transfusions
4. Strategies That Might Lower Blood Pressure Questioned
5. Factors That Might Increase The Risk Of Schizophrenia
6. A Drug That Might Relieve Chronic Cough
7. Biochemical Markers Might Help Predict Heart Problems
8. Yoga Might Be Helpful For Cancer Patients
9. Healthcare Professionals Might Want To Rethink Their Dress Code
10. Embryonic Cells Might Prevent Parkinson’s Disease From Worsenin
11. Counting Calories Might Be The Ideal Way To Stay Healthy
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: EBV Might Trigger Multiple Sclerosis Study

(Date:8/31/2015)... ... August 31, 2015 , ... Castle Dermatology Institute now ... Dr. Pedram Ghasri is a graduate of the University of California, Los Angeles. He ... studies at the University of California, Irvine Medical School. As a nationally recognized Regents ...
(Date:8/31/2015)... , ... August 31, 2015 , ... In preparation for ... Research, maker of the BEAN™ personal sound amplifier, is offering caregivers “7 Reasons to ... as a way of coping with a variety of home healthcare challenges, specifically as ...
(Date:8/31/2015)... ... August 31, 2015 , ... For 12 years, since ... acknowledged September 26th as Mesothelioma Awareness Day . On this day, and in ... several ways of becoming involved and helping the cause. , “One of the ways ...
(Date:8/31/2015)... ... August 31, 2015 , ... MeYou Health ®, a ... mobile walking app, Walkadoo , by including an in-app step tracker. , ... to each person’s walking habits. Rather than broadly assign every Walkadoo member 10,000 steps ...
(Date:8/31/2015)... ... 2015 , ... It’s a lot like coming home. Life-long Fox Valley resident ... his first days on the job, he’s run into residents of the retirement community ... knowing that they’re living in such a wonderful place,” he said. GreenFields, which is ...
Breaking Medicine News(10 mins):Health News:Castle Dermatology Institute Now Welcomes Dr. Pedram Ghasri to the Practice 2Health News:Etymotic Offers Caregivers “7 Reasons to Care about Hearing Health” 2Health News:Etymotic Offers Caregivers “7 Reasons to Care about Hearing Health” 3Health News:Cancer Research Organization Paints the World in Mesothelioma Awareness 2Health News:Cancer Research Organization Paints the World in Mesothelioma Awareness 3Health News:Walkadoo™ Walking Program Now Includes In-app Step Tracker 2Health News:Friendship Senior Options Welcomes New Executive Director for GreenFields of Geneva 2
... Benefits and Flavor of Fruit in a Zero-Calorie Fortified Water ... of Fruit2O(R), the original fruit flavored water, comes a new ... nutrients found in two servings of fruit with zero calories ... shown that 80 percent of Americans do not drink the ...
... ... Adoption of Healthcare Information Technology , ... Stamford, CT (PRWEB) June 4, 2009 -- IVANS, Inc. , ... survey that showed healthcare providers believe in the importance of reform, but are concerned ...
... Continued Market Leadership in Parenteral and Solutions/Nutritionals , ... Inc. (B. Braun) today announced that it had received ... highest year-over-year market share growth for distributed products in the ... , , (Logo: http://www.newscom.com/cgi-bin/prnh/20081022/NYW008LOGO ...
... overburdened if an outbreak were more severe , THURSDAY, June ... H1N1 swine flu outbreak that surfaced unexpectedly in April has ... , And those shortcomings could take on added urgency if ... fall, a new report found. , "It,s clear that ...
... , , HARRISBURG, Pa., June 4 Pennsylvania ... Estoydecidido.com , a resource tool to help Latino residents ... -- which translates to "I am determined" -- is ... site. , , "Latinos have become an emerging ...
... and the Alzheimer Research Forum announce the release of the ALS ... ), a web-based resource for researchers interested in amyotrophic lateral sclerosis ... The site is modeled on the Alzheimer Research Forum,s popular ... efforts to build a similar set of tools for ALS researchers. ...
Cached Medicine News:Health News:Fruit2O(R) Introduces New 'Essentials' Line 2Health News:Fruit2O(R) Introduces New 'Essentials' Line 3Health News:Providers Believe Healthcare Reform Will Increase Their Costs, According to IVANS Survey 2Health News:Providers Believe Healthcare Reform Will Increase Their Costs, According to IVANS Survey 3Health News:B. Braun Medical Wins Two GHX 2009 Best in Class Awards 2Health News:B. Braun Medical Wins Two GHX 2009 Best in Class Awards 3Health News:Report Gives U.S. Good Grades for Swine Flu Response 2Health News:Report Gives U.S. Good Grades for Swine Flu Response 3Health News:Report Gives U.S. Good Grades for Swine Flu Response 4Health News:Pennsylvania Department of Health Launches Spanish-Language Smoking Cessation Resource Web Site 2Health News:Prize4Life and the Alzheimer Research Forum Announce Launch of New Web-Portal for ALS Research 2Health News:Prize4Life and the Alzheimer Research Forum Announce Launch of New Web-Portal for ALS Research 3
(Date:8/31/2015)... Aug. 31, 2015 With increasing clinical ... experiencing a rise in active partnerships. The primary ... nations to quantitate CD4 cell markers in human ... http://photos.prnewswire.com/prnh/20150831/262206LOGO New analysis ... Flow Cytometry Market ( http://www.frost.com/nf0e ), finds the ...
(Date:8/31/2015)... Pa. , Aug. 31, 2015  The departments ... an event today at Gaudenzia Concept 90 to raise ... drug overdose crisis in Pennsylvania ... treatment and focus on recovery through the Building ... many Pennsylvanians are dying every day to a disease ...
(Date:8/31/2015)...  Diplomat Pharmacy, Inc. (NYSE: DPLO ), the nation,s ... , Chairman & CEO, and Sean Whelan , CFO, ... Mr. Hagerman and Mr. Whelan are scheduled to participate in ... on Wednesday, September 9, 2015 at 1:45 PM ... scheduled to participate in the Robert W. Baird 2015 Healthcare ...
Breaking Medicine Technology:Clinical Applications of Flow Cytometry Instrumentation and Reagents are Transforming this Market with a High-Growth Path 2Clinical Applications of Flow Cytometry Instrumentation and Reagents are Transforming this Market with a High-Growth Path 3Clinical Applications of Flow Cytometry Instrumentation and Reagents are Transforming this Market with a High-Growth Path 4Pennsylvania Departments of Drug & Alcohol Programs and Health Kick-off Second Annual Building Bridges to Recovery Initiative 2Diplomat to Participate in Upcoming Investor Conferences 2
... Blumenthal,Cancer Center at Carolinas Medical Center (CMC) in ... a study that could lead to individualized,treatments for ... hospital system,outside Moffitt,s home state of Florida to ... will enroll more than 2,300 patients in,the study, ...
... of patients remain symptom-free and off daily GERD ... after transoral incisionless ... EndoGastric Solutions, the,world leader in natural orifice surgery ... of 1-year follow-up on GERD patients,in the phase ...
Cached Medicine Technology:CMC, Moffitt Partner to Study Cancer 2EndoGastric Solutions(TM) Announces Results of EsophyX(TM) Multi-Center GERD Study 2EndoGastric Solutions(TM) Announces Results of EsophyX(TM) Multi-Center GERD Study 3EndoGastric Solutions(TM) Announces Results of EsophyX(TM) Multi-Center GERD Study 4
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: