Navigation Links
Drugs to stop burgeon of HIV

An Australian research team has discovered a way of preventing HIV from spreading from cell to cell.Professor Henry and colleagues from the John Curtin School of Medical Research have found the drug hexamethylene amiloride (HMA) appears to reduce the ability of viruses to escape from infected cells. This could develop into a new drug to tackle HIV.

"We have found a drug that blocks the channels HIV may use to spread to uninfected cells," said Professor henry.Budding is the method by which viruses spread. After working their way into cells and making copies of themselves, the virus goes to the surface membrane and wraps it around themselves before 'popping' off.//

In 1996 the researchers showed that a protein created by HIV called Vpu formed ion channels in fatty membranes around cells. Ion channels act as 'gates' for ions to pass in and out of the cell."We had to make a conceptual leap between ion channels and the budding process" said Professor Gage who works in the Division of Biochemistry and Molecular Biology at the Australian National University. "We had an idea this would affect it but we didn't know how."

"The same part of Vpu is involved in making ion channels and budding, so the ion channels formed by Vpu could have a role to play in budding," said Professor Henry.Earlier this year the researchers showed that Vpu could dramatically increase the rate of budding. They concluded Vpu is likely to be important in viral reproduction."We found if we mess around with Vpu, we can reduce the rate of HIV replication in cells. Vpu isn't essential for replication, but it has an effect on it."

The researchers showed that the drug HMA stops the enhancement of budding by Vpu which indicates it will reduce the spread of the virus. "The virus will still replicate, but eventually the cell dies and the viruses, defenceless without surface membranes, are eaten up by macrophages," he explained.

At present there are two types of anti-HIV drugs available – reverse transcriptase inhibitors such as AZT and protease inhibitors. These work by targeting the reproduction of the virus within the host cell."The problem is HIV can mutate to escape the drugs you are using to treat it," said Professor Gage. "If this occurs, the drug will kill off all non-mutated cells leaving only the mutated ones to thrive." Any drug that results from this research will work with the current treatments. "This will complement existing anti-HIV therapies," said Professor henry. The advantage of multi-drug treatment is a reduction in the probability of a mutated virus escaping the treatment. The team has been working on the project for the past couple of years .


'"/>




Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Life Saving Cancer Drugs – From Chicken! Possible Says Dolly’ Creatos
3. Nasal Spray Could Take Drugs Direct to Brain.
4. Emphasis to ban Drugs ads by Doctors
5. Osteoporosis Drugs: right time to take-off
6. Drugs disrupt formation of blood vessels
7. Misleading Advertisements for Prescription Drugs
8. Drugs For Anthrax May Interfere With Oral Contraceptives
9. Over-The-Counter Drugs May Prevent Alzheimers
10. Steps To Improve Quality Of Plant-Based Drugs
11. Nasal Spray Could Take Drugs Directly to Brain
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/24/2017)... ... May 24, 2017 , ... In modern ... the most appropriate instruments for research and understanding the basic principles that were ... will focus on innovations in stereo microscopy for brightfield and fluorescence typically used ...
(Date:5/24/2017)... ... ... Altec Products, Inc., a leader in enterprise document management and ... in San Diego, CA. , At nVerge 2017, Altec will be highlighting ... their Sage ERP solutions by providing improved visibility and control to the entire document ...
(Date:5/24/2017)... , ... May 24, 2017 , ... ... implants in Bayside, NY, who have now spent 10 years as clinical instructors ... York University (NYU) College of Dentistry. Through the program, private practitioners receive cutting-edge ...
(Date:5/24/2017)... ... 2017 , ... Patients who want to receive cosmetic dentistry procedures such as ... Bedich for a consultation, with or without a referral. Dr. Bedich enjoys improving the ... , Dr. Bedich offers a variety of cosmetic dentistry services at his practice ...
(Date:5/24/2017)... ... 2017 , ... Myers Jackson is well known for auctioning homes that people ... anywhere on the planet. The luxury home market is alive and well and there ... quick search of “11 Spyglass Hill Auction will enlighten you on the dynamics of ...
Breaking Medicine News(10 mins):
(Date:5/11/2017)... , May 11, 2017  Thornhill Research ... has been awarded an $8,049,024 USD five-year, firm-fixed-priced, ... through the Canadian Commercial Corporation (CCC) ( ... Anesthesia Systems to administer general anesthesia to patients ... "The US Marine Corps have been ...
(Date:5/10/2017)... BARRINGTON, Ill. , May 10, 2017 ... medicine today; unfortunately its costs have also spiraled to ... are being sent to radiology than ever before as ... and diagnosis.  For a patient with lower back pain ... prove no anatomical reason for pain, resulting in entirely ...
(Date:5/9/2017)... -- Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ) ... on the development of oral drug delivery systems, ... has granted Oramed a patent titled, "Methods and ... covers Oramed,s invention of an oral glucagon-like peptide-1 ... hormone that stimulates the secretion of insulin from ...
Breaking Medicine Technology: