Navigation Links
Drugs may Help Turn on Gene Switched Off in Cancer

Researchers from the University of Michigan Comprehensive Cancer Center suggest that drugs may be helpful in switching on a gene implicated in the development of cancer cells , raising hope for the development of a new class of targeted therapies with potential to benefit many different cancer types.

During the study, the researchers found that a gene called Brahma (BRM) was silent, but not missing, in some cancer cells. They found that the gene was turned off in about 15 percent of tumours studied, including cells from lung, oesophageal, ovarian, bladder, colon and breast cancers.

When the BRM gene was exposed to some of the existing inhibitor drugs, it was turned on. The finding attains significance because many times cancers occur when genes that control growth are turned off.

The researcher though concede that new drugs need to be developed to be more effective in reactivating this gene in cancer cells, they insist that their finding may lead to new targets for cancer treatment.

This is a targetable target. We can detect it, but we need to find a better way to turn it back on. No drugs are designed to deal with a gene thats turned off. But its a straightforward extension of current therapies that target genes that are turned on, says lead study author Dr. David Reisman, Assistant Professor of Internal Medicine at the U-M Medical School.

The study, published in the journal Oncogene, involved the use of a class of drugs called histone deacetylase inhibitors, or HDAC inhibitors.

While the existing HDAC inhibitors were found to switch on the BRM gene, the effect was short-lived and reduced as the drugs were taken away. The HDAC inhibitors are not the perfect answer, but in principle this tells us we can turn our gene back on. If we can turn the gene back on, it may not be a cure for cancer, but it could slow it down or make it responsive to existing drugs, Reisman says.

The researchers targeted lung cancer cell lines in particular, although they found similar results in a variety of other cancer cell lines tested. Tumours are not the same from one person to the next, and even the cells within a single tumour are not the same. Giving a single drug or drug combination to 500 people is setting ourselves up for failure, much like a one-size-fits-all clothing store would never succeed, Reisman says.

Targeted therapies are now opening the door, because they are essentially given only to those patients who have a high likelihood of response. Their low toxicity means the patient can be treated for long periods of time, which is unlike older and more traditional chemotherapy agents. Even if these new targeted therapies dont cure the cancer, we can at least have long-term survival, he adds.


Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Life Saving Cancer Drugs – From Chicken! Possible Says Dolly’ Creatos
3. Nasal Spray Could Take Drugs Direct to Brain.
4. Emphasis to ban Drugs ads by Doctors
5. Osteoporosis Drugs: right time to take-off
6. Drugs disrupt formation of blood vessels
7. Drugs to stop burgeon of HIV
8. Misleading Advertisements for Prescription Drugs
9. Drugs For Anthrax May Interfere With Oral Contraceptives
10. Over-The-Counter Drugs May Prevent Alzheimers
11. Steps To Improve Quality Of Plant-Based Drugs
Post Your Comments:

(Date:11/25/2015)... ... ... Today, Mothers Against Drunk Driving (MADD) learned that the number ... first time since 2011. In 2014, there were 9,967 fatalities involving an alcohol impaired ... Highway Traffic Safety Administration (NHTSA), 32,675 people were killed in traffic crashes in 2014. ...
(Date:11/25/2015)... ... November 25, 2015 , ... "When ... that regular bras were incredibly uncomfortable," said an inventor from Bronx, N.Y. "In ... She developed the patent-pending RECOVERY BRA for added comfort and support. The bra ...
(Date:11/25/2015)... ... November 25, 2015 , ... Many people know of the common symptoms ... hands, and dry skin. But many people who find their cholesterol levels and weight ... of their thyroid, especially if they don’t have any of the other symptoms. , ...
(Date:11/25/2015)... ... 2015 , ... Students and parents have something to be thankful for this ... Impact awards. California Casualty is proud to support the contest designed to ... reckless driving, the number one killer of young drivers. , Almost 1,000 entries ...
(Date:11/24/2015)... ... 2015 , ... Eric C. Seidel, DMD and Stephanie DeFilippo, ... revolutionary BIOLASE WaterLase iPlus 2.0™ system. This advanced laser technology uses light energy ... dentist in Gettysburg, PA . From routine visits to cosmetic treatments, laser dentistry ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... 25, 2015 Allergan plc (NYSE: AGN ) ... New York State Attorney General,s Office ... Act, and other statutes with the Attorney General over the ... cease marketing and selling the now generic version of memantine ... no liability, has released its counterclaims against New ...
(Date:11/25/2015)... 2015 USP 800 applies to all ... pharmacists, pharmacy technicians, nurses, physicians, physician assistants, home ... also covers all entities which store, prepare, transport, ... healthcare institutions, patient treatment clinics, physicians, practice facilities, ... --> What is the purpose of ...
(Date:11/25/2015)... - Will Also Offer Point -of- ... --> - Will Also Offer Point ... --> - Will Also Offer ... (CME) Elsevier , a world-leading provider of ... diagnostic imaging textbooks and decision support tools, as well as prominent ...
Breaking Medicine Technology: