Navigation Links
Drugs Delivery Revolutionized by Extremely Stable Glass

A new approach to drug delivery has been achieved. This is made possible with the invention of unusually strong and stable glass made from organic material.// It can be coated with drugs and then chilled. The journal Science has reported the advanced processing by researchers from the University of Wisconsin-Madison and the National Institute of Standards and Technology (NIST) Center for Neutron Research (NCNR).

Pharmaceutical compounds can now be made in non crystalline forms that are readily absorbed by the body, said the researchers. Recent research have been striving to develop such amorphous pharmaceutical compounds to enhance drug delivery to specific targets in the body The new technique entails depositing vapors of organic molecules onto a substrate cooled to 50 degrees (Celsius) below the glass transition temperature—the point at which a compound normally begins to solidify en route to becoming glass, a frozen, liquid-like structure with no long-range internal order. Conceived by UW-Madison chemist Mark Ediger and colleagues, the method short-circuits the conventional cooling process to great practical advantage.

The result, the researchers say, is a dramatically altered internal "energy landscape." The glass molecules position themselves more densely in low-energy valleys that dot this landscape. In contrast, the molecules that make up conventional glasses are dispersed more widely and become "frozen" on higher-energy bluffs and mesas.

Conventional glasses are less stable thermodynamically, because the molecules gradually abandon the higher-energy elevations. During processing or over time, a conventional glass is more apt to convert to a low-energy crystalline order, changing the structural nature of the material. This can be a problem for amorphous pharmaceuticals, in particular. If the internal structure changes during storage, for example, properties such as solubility also will change, potentially undermining the effec tiveness of the drug.

Studies at the NCNR confirmed that molecules in glasses prepared with the team’s vapor-deposition method were very densely packed, yet true glasses—amorphous in arrangement. Neutron probes also were used to study how molecules diffuse during subsequent annealing of the two types of glass samples. After 16 hours of annealing, molecules in the new glass remained fixed in place. The conventional sample, by contrast, began bulk molecular diffusion after less than 30 minutes of annealing.



Source-Eurekalert
MT
'"/>




Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Life Saving Cancer Drugs – From Chicken! Possible Says Dolly’ Creatos
3. Nasal Spray Could Take Drugs Direct to Brain.
4. Emphasis to ban Drugs ads by Doctors
5. Osteoporosis Drugs: right time to take-off
6. Drugs disrupt formation of blood vessels
7. Drugs to stop burgeon of HIV
8. Misleading Advertisements for Prescription Drugs
9. Drugs For Anthrax May Interfere With Oral Contraceptives
10. Over-The-Counter Drugs May Prevent Alzheimers
11. Steps To Improve Quality Of Plant-Based Drugs
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/15/2017)... ... January 15, 2017 , ... Going above ... program that strives to better communities around the world by offering the Gensuite ... provides the opportunity for team members to become involved in a cause that ...
(Date:1/15/2017)... ... January 15, 2017 , ... San Francisco Magazine ... Bay Area counties for 2017. Almost 1,000 nominations were submitted and a little ... process. Results were announced the magazine’s January 2017 issue . , Under ...
(Date:1/14/2017)... ... January 14, 2017 , ... Healthy ... expanding line of activated charcoal products. With more and more people opting to ... products according to how they cater to specific needs. , Moody Zook focused ...
(Date:1/13/2017)... ... January 13, 2017 , ... People ... levels. Counting carbohydrates is as easy as checking the nutrition label on foods ... blood sugar levels. Despite being sugar-free, proteins can influence — either positively or ...
(Date:1/13/2017)... ... , ... With the increasing public preference for chemical-free personal ... alternatives for customers who have grown more conscious about maintaining their health and ... charcoal products, Moody Zook Chief Executive Officer Nate Ginsburg explained their company’s decision ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... YORK , Jan. 16, 2017 ... Densitometers Market Outlook to 2022", provides key market data ... provides value, in millions of US dollars, volume (in ... Dual Energy X-Ray Absorptiometry (DEXA) and Quantitative Ultrasound (QUS). ... shares data for each of these market segements, and ...
(Date:1/16/2017)... 16, 2017  Verathon ® Inc., a leading manufacturer and ... new GlideScope ® Spectrum TM Single-Use video laryngoscopes. ... and Ambient Light Reduction TM technology, which actively optimizes ... ... Introducing another bright idea ...
(Date:1/16/2017)... , Jan. 16, 2017 When synthetic Fentanyl ... market their product as top-rate. They offered free samples, inviting ... customer service. Soon, business was booming. ... described as 100 times more powerful than morphine, has racked ... in last 2 years. One dealer,s recorded fentanyl sales ...
Breaking Medicine Technology: