( A new approach to drug delivery has bee...)Drugs Delivery Revolutionized by Extremely Stable Glass,Health

A new approach to drug delivery has been achieved. This is made possible with the invention of unusually strong and stable glass made from organic material.// It can be coated with drugs and then chilled. The journal Science has reported the advanced processing by researchers from the University of Wisconsin-Madison and the National Institute of Standards and Technology (NIST) Center for Neutron Research (NCNR).

Pharmaceutical compounds can now be made in non crystalline forms that are readily absorbed by the body, said the researchers. Recent research have been striving to develop such amorphous pharmaceutical compounds to enhance drug delivery to specific targets in the body The new technique entails depositing vapors of organic molecules onto a substrate cooled to 50 degrees (Celsius) below the glass transition temperature—the point at which a compound normally begins to solidify en route to becoming glass, a frozen, liquid-like structure with no long-range internal order. Conceived by UW-Madison chemist Mark Ediger and colleagues, the method short-circuits the conventional cooling process to great practical advantage.

The result, the researchers say, is a dramatically altered internal "energy landscape." The glass molecules position themselves more densely in low-energy valleys that dot this landscape. In contrast, the molecules that make up conventional glasses are dispersed more widely and become "frozen" on higher-energy bluffs and mesas.

Conventional glasses are less stable thermodynamically, because the molecules gradually abandon the higher-energy elevations. During processing or over time, a conventional glass is more apt to convert to a low-energy crystalline order, changing the structural nature of the material. This can be a problem for amorphous pharmaceuticals, in particular. If the internal structure changes during storage, for example, properties such as solubility also will change, potentially undermining the effec
'"/>




Page: 1 2
Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Life Saving Cancer Drugs – From Chicken! Possible Says Dolly’ Creatos
3. Nasal Spray Could Take Drugs Direct to Brain.
4. Emphasis to ban Drugs ads by Doctors
5. Osteoporosis Drugs: right time to take-off
6. Drugs disrupt formation of blood vessels
7. Drugs to stop burgeon of HIV
8. Misleading Advertisements for Prescription Drugs
9. Drugs For Anthrax May Interfere With Oral Contraceptives
10. Over-The-Counter Drugs May Prevent Alzheimers
11. Steps To Improve Quality Of Plant-Based Drugs