Navigation Links
Drugs Delivery Revolutionized by Extremely Stable Glass

A new approach to drug delivery has been achieved. This is made possible with the invention of unusually strong and stable glass made from organic material.// It can be coated with drugs and then chilled. The journal Science has reported the advanced processing by researchers from the University of Wisconsin-Madison and the National Institute of Standards and Technology (NIST) Center for Neutron Research (NCNR).

Pharmaceutical compounds can now be made in non crystalline forms that are readily absorbed by the body, said the researchers. Recent research have been striving to develop such amorphous pharmaceutical compounds to enhance drug delivery to specific targets in the body The new technique entails depositing vapors of organic molecules onto a substrate cooled to 50 degrees (Celsius) below the glass transition temperature—the point at which a compound normally begins to solidify en route to becoming glass, a frozen, liquid-like structure with no long-range internal order. Conceived by UW-Madison chemist Mark Ediger and colleagues, the method short-circuits the conventional cooling process to great practical advantage.

The result, the researchers say, is a dramatically altered internal "energy landscape." The glass molecules position themselves more densely in low-energy valleys that dot this landscape. In contrast, the molecules that make up conventional glasses are dispersed more widely and become "frozen" on higher-energy bluffs and mesas.

Conventional glasses are less stable thermodynamically, because the molecules gradually abandon the higher-energy elevations. During processing or over time, a conventional glass is more apt to convert to a low-energy crystalline order, changing the structural nature of the material. This can be a problem for amorphous pharmaceuticals, in particular. If the internal structure changes during storage, for example, properties such as solubility also will change, potentially undermining the effec tiveness of the drug.

Studies at the NCNR confirmed that molecules in glasses prepared with the team’s vapor-deposition method were very densely packed, yet true glasses—amorphous in arrangement. Neutron probes also were used to study how molecules diffuse during subsequent annealing of the two types of glass samples. After 16 hours of annealing, molecules in the new glass remained fixed in place. The conventional sample, by contrast, began bulk molecular diffusion after less than 30 minutes of annealing.



Source-Eurekalert
MT
'"/>




Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Life Saving Cancer Drugs – From Chicken! Possible Says Dolly’ Creatos
3. Nasal Spray Could Take Drugs Direct to Brain.
4. Emphasis to ban Drugs ads by Doctors
5. Osteoporosis Drugs: right time to take-off
6. Drugs disrupt formation of blood vessels
7. Drugs to stop burgeon of HIV
8. Misleading Advertisements for Prescription Drugs
9. Drugs For Anthrax May Interfere With Oral Contraceptives
10. Over-The-Counter Drugs May Prevent Alzheimers
11. Steps To Improve Quality Of Plant-Based Drugs
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has released ... understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a picture ... Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that is ...
(Date:10/13/2017)... ... 2017 , ... Coveros, a leader in agile coaching services ... by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile Transformation ... Agile methodologies in a consistent and high value manner across CMS programs. Coveros ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history ... The Brink” is the creation of published author, William Nowers. Captain Nowers and ... WWII veteran, he spent thirty years in the Navy. Following his career as ...
(Date:10/12/2017)... ... 12, 2017 , ... CitiDent and San Francisco dentists, Dr. ... Oventus O2Vent technology. As many as 18 million Americans are estimated to suffer ... Oral appliances can offer significant relief to about 75 percent of people with ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has ... today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every formula ... the highest standard. , These products are also: Gluten Free, Non-GMO, Vegan, ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... , Oct. 10, 2017  NDS received FDA 510(k) clearance ... a medical-grade battery-powered display stand specifically designed for endoscopy environments. An ... technology into a clinical solution to support the improvement of patient ... Innovative Design ... Wireless Solution ...
(Date:10/5/2017)... Ill. , Oct. 5, 2017  In ... Association of Oral and Maxillofacial Surgeons (AAOMS) released ... opioids – to be used as a first-line ... pain. Recognizing ... the AAOMS White Paper "Opioid Prescribing: Acute and ...
(Date:10/4/2017)... Oct. 4, 2017 OBP Medical ... illuminating medical devices, today announced regulatory approval from ... Agency (or Agência Nacional de Vigilância Sanitária (ANVISA)) ... cordless surgical retractor with integrated LED light source ... illumination and exposure of a tissue pocket or ...
Breaking Medicine Technology: