Navigation Links
Drug to Prevent the Onset of Arthritis

Arthritis is a common health problem worldwide. Both osteoarthritis and rheumatoid arthritis cause joint pain and //stiffness in patients. There is no cure for arthritis and no effective treatment to repair damaged cartilage.

A new study could help lead doctors towards a drug to prevent the onset of arthritis. The research pinpoints the molecular pathway and an enzyme that play a pivotal role in the onset of the condition. Researchers from Cardiff University conducted research to better understand the molecular pathway involved in the onset of arthritis.

Early research has shown activity levels of two enzymes, MMP-2 and MMP-9, are frequently increased in the cartilage of people suffering from osteoarthritis. Researchers also know, in patients with arthritis, the cartilage releases a substance called proteoglycan. Scientists cultured cartilage cells in vitro to study this pathway as osteoarthritis develops.

The researchers stimulated the cells with two molecules that activate the arthritis processes. This caused the increased release of proteoglycan and the production and activation of MMPs. Researchers then inhibited the enzyme PKR in the cells. This time they found no increase in the activation of MMPs and that the release of proteoglycan was significantly reduced.

Researchers say the results of this study imply that PKR is involved in the molecular pathways that are implicated in the progression of arthritis. They hope this understanding will help in the discovery of novel targets for arthritis drugs.


'"/>




Page: 1

Related medicine news :

1. Lose stomach for Life....Preventive removal of stomach saves the risk of cancer
2. Prevention is better than cure
3. Prevention of cataracts
4. Medications to Prevent Relapse to Cocaine Use
5. Estrogen Does Not Prevent Recurrent Strokes
6. Over-The-Counter Drugs May Prevent Alzheimers
7. Aspirin and Warfarin Are Equally Effective for Stroke Prevention
8. Alcoholism Drug Fails To Prevent Drinking Relapses
9. Preventing mental decline in the aged
10. Preventing white coat hypertension
11. Simple Stroke Prevention is Best
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/25/2017)... ... , ... Buyers and sellers in the thriving multi-billion dollar cannabis marketplace – ... but be heartened by the industry’s current surge. But another thing that unifies them ... At last they can simply, safely and effectively end their aroma anguish thanks ...
(Date:4/25/2017)... ... April 25, 2017 , ... There is no better place ... to a special report in the May issue of Consumer Reports focused on heart ... ranking for results achieved during and after coronary bypass and aortic valve replacement procedures. ...
(Date:4/24/2017)... FLORIDA (PRWEB) , ... April 24, 2017 , ... ... telehealth technology yesterday, featuring Bring Your Own Device (BYOD) capabilities at Telehealth 2.0, ... LG CNS’ pre-packaged telehealth bundles, which pairs medical devices with a pre-programmed tablet ...
(Date:4/24/2017)... ... April 24, 2017 , ... As part of the ... to honor the victims of the Holocaust and Nazi persecution, Center for Medicine ... and Auschwitz on its CMATH Champions trip to Germany and Poland next week. , ...
(Date:4/24/2017)... ... April 24, 2017 , ... The California Dental Association Foundation’s two-day volunteer dental ... 1,961 people during the April 22-23 event at the San Mateo Event Center. ... barriers to care, CDA Cares educates the public and policymakers about the importance of ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... DALLAS , April 19, 2017 /PRNewswire/ ... that the first patients in Nashville ... in the Lower Esophageal Sphincter Stimulation for GERD (LESS ... device designed to provide long-term reflux control by restoring ... GERD affects nearly 65 million people in ...
(Date:4/19/2017)... , April 19, 2017 ... stimulate an immune response in pets such as ... products are of various types such as Attenuated ... Toxoid Vaccines, DNA Vaccines and Recombinant Vaccines. Attenuated ... as virus or bacteria, which have been weakend ...
(Date:4/19/2017)... Calif. , April 19, 2017  SARES•REGIS ... buildings it is developing at Conejo Spectrum Business ... , to Atara Biotherapeutics, Inc. , a ... severe and life-threatening diseases that have been underserved ... allogeneic T-cell therapies for cancer, autoimmune and infectious ...
Breaking Medicine Technology: