Navigation Links
Drug to Prevent the Onset of Arthritis

Arthritis is a common health problem worldwide. Both osteoarthritis and rheumatoid arthritis cause joint pain and //stiffness in patients. There is no cure for arthritis and no effective treatment to repair damaged cartilage.

A new study could help lead doctors towards a drug to prevent the onset of arthritis. The research pinpoints the molecular pathway and an enzyme that play a pivotal role in the onset of the condition. Researchers from Cardiff University conducted research to better understand the molecular pathway involved in the onset of arthritis.

Early research has shown activity levels of two enzymes, MMP-2 and MMP-9, are frequently increased in the cartilage of people suffering from osteoarthritis. Researchers also know, in patients with arthritis, the cartilage releases a substance called proteoglycan. Scientists cultured cartilage cells in vitro to study this pathway as osteoarthritis develops.

The researchers stimulated the cells with two molecules that activate the arthritis processes. This caused the increased release of proteoglycan and the production and activation of MMPs. Researchers then inhibited the enzyme PKR in the cells. This time they found no increase in the activation of MMPs and that the release of proteoglycan was significantly reduced.

Researchers say the results of this study imply that PKR is involved in the molecular pathways that are implicated in the progression of arthritis. They hope this understanding will help in the discovery of novel targets for arthritis drugs.


'"/>




Page: 1

Related medicine news :

1. Lose stomach for Life....Preventive removal of stomach saves the risk of cancer
2. Prevention is better than cure
3. Prevention of cataracts
4. Medications to Prevent Relapse to Cocaine Use
5. Estrogen Does Not Prevent Recurrent Strokes
6. Over-The-Counter Drugs May Prevent Alzheimers
7. Aspirin and Warfarin Are Equally Effective for Stroke Prevention
8. Alcoholism Drug Fails To Prevent Drinking Relapses
9. Preventing mental decline in the aged
10. Preventing white coat hypertension
11. Simple Stroke Prevention is Best
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... Cary, North Carolina (PRWEB) , ... June 26, 2016 , ... ... the release of a new product that was developed to enhance the health of ... harvested for centuries. , The two main herbs in the PawPaws Cat Kidney ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American Institutes ... Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , ... advance care planning, healthcare costs and patient and family engagement. , AIR researchers ...
(Date:6/25/2016)... ... , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize ... Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into ... Simply select a ProHand generator and drag it above media or text in the ...
(Date:6/25/2016)... , ... June 25, 2016 , ... ... and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a ... area —Johnson is one of the first doctors to perform the treatment. Orthobiologics ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... A ... procedures that most people are unfamiliar with. The article goes on to state that ... but also many of these less common operations such as calf and cheek reduction. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical ... the "Company"), which develops, markets and sells medical devices ... , signed a strategic cooperation agreement with Hongyuan ... "Hongyuan Supply Chain") on June 20, 2016, to develop ... the strategic cooperation agreement, Dehaier will leverage Hongyuan Supply ...
(Date:6/24/2016)... Mass. , June 24, 2016   Pulmatrix, ... pharmaceutical company developing innovative inhaled drugs, announced today that ... Russell Investments reconstituted its comprehensive set of ... "This is an important milestone for Pulmatrix," ... will increase shareholder awareness of our progress in developing ...
(Date:6/23/2016)... 2016 Research and Markets has announced ... Forecast to 2022" report to their offering. ... the patients with kidney failure, it replaces the function of ... patient,s blood and thus the treatment helps to keep the ... balance. Increasing number of ESRD patients & ...
Breaking Medicine Technology: