Navigation Links
Drug to Prevent the Onset of Arthritis

Arthritis is a common health problem worldwide. Both osteoarthritis and rheumatoid arthritis cause joint pain and //stiffness in patients. There is no cure for arthritis and no effective treatment to repair damaged cartilage.

A new study could help lead doctors towards a drug to prevent the onset of arthritis. The research pinpoints the molecular pathway and an enzyme that play a pivotal role in the onset of the condition. Researchers from Cardiff University conducted research to better understand the molecular pathway involved in the onset of arthritis.

Early research has shown activity levels of two enzymes, MMP-2 and MMP-9, are frequently increased in the cartilage of people suffering from osteoarthritis. Researchers also know, in patients with arthritis, the cartilage releases a substance called proteoglycan. Scientists cultured cartilage cells in vitro to study this pathway as osteoarthritis develops.

The researchers stimulated the cells with two molecules that activate the arthritis processes. This caused the increased release of proteoglycan and the production and activation of MMPs. Researchers then inhibited the enzyme PKR in the cells. This time they found no increase in the activation of MMPs and that the release of proteoglycan was significantly reduced.

Researchers say the results of this study imply that PKR is involved in the molecular pathways that are implicated in the progression of arthritis. They hope this understanding will help in the discovery of novel targets for arthritis drugs.


'"/>




Page: 1

Related medicine news :

1. Lose stomach for Life....Preventive removal of stomach saves the risk of cancer
2. Prevention is better than cure
3. Prevention of cataracts
4. Medications to Prevent Relapse to Cocaine Use
5. Estrogen Does Not Prevent Recurrent Strokes
6. Over-The-Counter Drugs May Prevent Alzheimers
7. Aspirin and Warfarin Are Equally Effective for Stroke Prevention
8. Alcoholism Drug Fails To Prevent Drinking Relapses
9. Preventing mental decline in the aged
10. Preventing white coat hypertension
11. Simple Stroke Prevention is Best
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2017)... ... May 26, 2017 , ... Rob Lowe acts as ... production of the series is on hiking in American. Viewers can reconnect with America ... great benefits of hiking. , Many consumers have looked for an inventive new place ...
(Date:5/26/2017)... ... May 26, 2017 , ... “THE FLINTHILLS FAMILY-Our Journey to the Cross”: the personal journey of ... Cross” is the creation of published authors, Bob and Margaret Massey. Bob Massey is ... is "panther quick and leather tough." His love for others is apparent in all ...
(Date:5/26/2017)... ... ... Jack: Against All Odds”: the story of Coach Cactus Jack and the impact he ... creation of published author, Walter Hubbard, a retired wildlife and fisheries biologist and pharmacy ... Walter and Jane have three adult children and a granddaughter. Walter and ...
(Date:5/24/2017)... ... May 24, 2017 , ... In ... choosing the most appropriate instruments for research and understanding the basic principles that ... webinar will focus on innovations in stereo microscopy for brightfield and fluorescence typically ...
(Date:5/24/2017)... California (PRWEB) , ... May 24, 2017 , ... ... through innovative medical image management and interpretation, has received U.S. Food and Drug ... , Nucleus.io is a web-based, scalable and secure cloud platform for medical image ...
Breaking Medicine News(10 mins):
(Date:5/15/2017)... Inc., a privately-held CNS pharmaceutical company based in ... disease (PD), has enrolled the first patient in the RASMET ... study involving patients with PD and taking place at 12 ... period. The first stage is open label and involves single ... Denver , Boca Raton ...
(Date:5/10/2017)... Global Health Intelligence (GHI), the leading healthcare data analytics ... 2017 ranking of the Best-Equipped Hospitals in Latin America ... GHI,s hospitals database for Latin America , which is ... database covers 86% of the hospitals in Latin ... each institution in key areas such as beds, medical specialties, ...
(Date:5/9/2017)... -- Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), ... has earned a spot on Forbes, "America,s ... ranked among 500 U.S. employers as well as in ... Services. The annual Forbes rankings ... of over 30,000 employees across 25 industries. The survey ...
Breaking Medicine Technology: