Navigation Links
Drug for Blood Pressure also Treats Lung Cancer

A hormone that is important in the control of blood pressure also shrinks lung cancer tumors in mice, suggesting a new way to prevent or treat the deadly cancer, according to scientists. //

Reporting in the journal Cancer Research, the scientists said that in mice treated with the hormone, angiotensin-(1-7), tumor volume decreased by 30 percent. In mice that did not receive the treatment, the tumor size more than doubled.

Patricia E. Gallagher, Ph.D., and E. Ann Tallant, Ph.D., senior researchers on the project, had previously reported a similar effect in lung cancer cells studied in the laboratory.

'The current study is the first demonstration of the effect in animals,' said Tallant. 'Taken together, the two studies suggest a novel treatment for lung cancer, a disease that kills an estimated 170,000 Americans each year.'

Wake Forest's Comprehensive Cancer Center will begin studies of the hormone in cancer patients.

'We hope that our clinical trials of angiotensin-(1-7) will lead to the identification of an effective new cancer treatment for our patients,' said Frank M. Torti, M.D., M.P.H., director of the Cancer Center, which helped fund the early development of angiotensin (1-7) as an anticancer treatment.

Lung cancer is the leading cause of death in developed countries, accounting for about 170,000 new cases each year in the U.S. In almost two-thirds of cases, the cancer has spread to the lymph nodes by the time of diagnosis, reducing the chances of successful treatment. The five-year survival rate for lung cancer is about 14 percent, the researchers said.

'This grim prognosis indicates a continued need for novel treatment approaches to reduce lung cancer deaths,' said Gallagher.

The idea to evaluate the effects of angiotensin-(1-7) on lung cancer came from studies observing that rates of lung cancer were lower in people whose high blood pressure was treated with angio tensin-converting enzyme (ACE) inhibitors. These drugs, which include Capoten? and Lotensin?, increase levels of angiotensin-(1-7) in the bloodstream.

Gallagher and Tallant have been working with angiotensin -(1-7) for years as members of the Hypertension and Vascular Research Center faculty. Carlos M. Ferrario, M.D., center director, discovered angiotensin-(1-7) in 1988, and found it to be a critical element of the blood pressure control system. The hormone relaxes (dilates) the walls of the blood vessels, causing blood pressure to be lowered. ACE inhibitors may work by increasing angiotensin-(1-7).

For the current study, human cancer cells were obtained from the American Tissue Culture Collection. Mice were inoculated with the cells and 32 days later were randomly selected to receive either an intravenous treatment of angiotensin-(1-7) or saline for 28 days. The blood levels of angiotensin-(1-7) achieved through treatment were similar to levels in humans being treated with an ACE inhibitor.

'The study may explain the molecular mechanism for a decreased risk of lung cancers in patients with high blood pressure taking ACE inhibitors,' said Tallant.

The researchers believe that angiotensin-(1-7) reduces cyclooxygenase-2 (COX-2), an enzyme that regulates cell growth. COX-2 is found at higher levels in 70 to 90 percent of malignant lung tumors.

Theoretically, drugs to reduce COX-2 would also be effective at shrinking tumors. But the drugs, such as Vioxx?, have been shown to increase the risk of heart attack, stroke and angina.

The researchers said that additional studies of angiotensin-(1-7) are needed, but that the hormone shows promise as a lung cancer treatment – either alone or in combination with other drugs.

Source-Eurekalert
'"/>




Related medicine news :

1. Recommendations for Treatment of Blood Pressue
2. Blood Cells Capable of Regenerating Liver
3. Blood clots likely in long travel
4. Hemochromatosis Patients Blood is Safe
5. Blood transfusions beneficial after heart attacks
6. Blood Pressure Drug may slow wasting in burn victims
7. Levels Of Blood Proteins May Help Heart Disease Care
8. Blood test may identify ovarian cancer
9. A Blood test for suicide risk?
10. Blood Pressure Drugs maintain muscle strength
11. Blood test diagnoses heart failure in short time
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, https://wcg.swoogo.com/modern-sop-and-quality-systems , Are one’s SOPs written for the ...
(Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
(Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
(Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
(Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
Breaking Medicine News(10 mins):
(Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
(Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
(Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
Breaking Medicine Technology: