Navigation Links
Drug Risks Must Be Balanced Against Benefits, Researchers

Concern over side effects of various drugs could be increasing, especially so in the wake of some high profile recalls like Vioxx, the osteoarthritis drug.

But dont throw the baby with bathwater, advise Boston researchers at the Tufts-New England Medical Center.

In an analysis appearing in the May/June issue of Health Affairs, researchers compared half a dozen risky drugs to various occupational, recreational and transportation activities, with sometimes surprising results. For instance, few people know that aspirin carries a high risk of gastrointestinal bleeding.

"You can't evaluate the acceptability of a risk without also looking at the benefit of associated activities, because risks are inevitable in all areas of life," study author Joshua Cohen said. "We wanted to see if we could compare risks associated with medication use with other risks that people might be more familiar with."

To that end, Cohen and a colleague evaluated the risk of dying after the use of six drugs: smallpox vaccine; antihistamines for the treatment of allergies for four months out of every year; aspirin for cardiovascular protection; clozapine to treat schizophrenia; Tysabri, a multiple-sclerosis drug; and Vioxx, the now-retired painkiller.

These were then compared to various non-drug activities, with these findings:

* Taking aspirin carries a risk of death similar to driving a car or working as a firefighter. "Motor vehicle risk I've always known to be a very big risk," Cohen said. "The risk associated with aspirin is just as big."

* The risk of dying from Vioxx or Tysabri is about the same as dying in a car, working as a truck driver or rock climbing.

* The odds of dying from aspirin, clozapine, Tysabri and Vioxx are about equal to the corresponding risk for driving in a passenger car.

* Out of all modes of transportation, only motorcycles pose a greater risk (450 per 100,000 perso n-years) than all drugs, even Vioxx, which had a 76 per 100,000 person-years fatality rate.

* Aspirin, clozapine, Tysabri and Vioxx all had risks equal to or greater than the annual mortality risks for firefighters and law enforcement workers (about 11 per 100,000 person-years). The most risky occupation -- tree fallers -- was much higher than any drug, at 360 per 100,000 person-years.

* Rock climbing (36 deaths per 100,000 person-years) had a mortality rate about equivalent to clozapine, while climbing in the Himalayas (13,000 per 100,000 person-years) had a higher risk of death than any of the drugs studied.

* And, just as a curiosity, the researchers found that motorcyclists can potentially face annual fatality risks that are 40 times as great as passenger car travelers, while taxi drivers face three times the death risk of firefighters.

"What we found, and this isn't a huge surprise, is that there are a lot of activities that people engage in voluntarily that have associated with them risks comparable to medication risks," Cohen said. "People must be taking into account benefits for those activities."

But perhaps the illustrations highlighted in this paper will help people make those decisions more clear-headedly, he said.

"When it comes to medication, we have to be methodological and cool-headed in looking at risks, not that they should be ignored, but we need to look at them within a framework," Cohen suggested.. "We need a way of thinking about these risks rationally."


'"/>




Related medicine news :

1. Simvastatin Plus Niacin May Lower Heart Risks
2. Risks for Silent Strokes
3. Ginseng Associated with Pregnancy Risks
4. Benefits and Risks of Asthma Treatment Questioned
5. Lack of Smell And Its Potential Risks
6. A Slight Increase In BP Can Mean big Risks
7. The Risks Of Smoking
8. Risks Of An Enlarged Heart
9. Identifying The Risks Of Developing Schizophrenia
10. Evaluating The Risks and Benefits of Hormone Therapy
11. The Risks Of Vitamin D Deficiency
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal their media with ... X," said Christina Austin - CEO of Pixel Film Studios. , ProSlice Color ... users can now reveal the media of their split screens with growing colorful ...
(Date:6/27/2016)... ... ... TopConsumerReviews.com recently awarded their highest five-star rating to Best Buy Eyeglasses, an ... United States and Canada wear eyeglasses. Once considered to be a purely functional part ... fashion statement. Even celebrities use glasses as a way of creating an iconic image—like ...
(Date:6/26/2016)... ... 2016 , ... PawPaws brand pet supplements owned by Whole Health ... the health of felines. The formula is all-natural and is made from Chinese herbs ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia ...
(Date:6/25/2016)... Austin, TX (PRWEB) , ... June 25, 2016 , ... ... Fellow of the American College of Mohs Surgery and to Dr. Russell Peckham for ... popular and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Bracket , a ... its next generation clinical outcomes platform, Bracket eCOA (SM) ... on June 26 – 30, 2016 in Philadelphia ... electronic Clinical Outcome Assessment product of its kind to fully ... Bracket eCOA 6.0 is a flexible platform for ...
(Date:6/23/2016)... Revolutionary technology includes multi-speaker listening ... industry leaders in advanced audiology and hearing aid technology, ... ™, the world,s first internet connected hearing aid that ...      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) , ... ,world firsts,: , TwinLink™ - the first ...
(Date:6/23/2016)... , June 23, 2016  Experian Health, ... and transforming the patient payment and care ... innovative new products and services that will ... revenue cycle offerings. These award-winning solutions will ... workflows, remain compliant in an ever-changing environment ...
Breaking Medicine Technology: