Drinking heavy amounts of alcohol over a long period of time may decrease brain volume, according to research that will be presented at the American Academy of Neurology's 59th Annual Meeting in Boston, April 28 May 5, 2007.

The study involved MRI scans of 1,839 people from the Framingham Offspring study, ages 34 to 88, who were classified as non-drinkers, former drinkers, low drinkers (one to seven drinks per week), moderate drinkers (eight to 14 drinks per week), or high drinkers (more than 14 drinks per week). MRI scans were performed and used to measure brain volume, which can be thought of as a measure of brain aging.

The study found the more alcohol people drink on a regular basis, the lower their brain volume.

"Research has shown that there is a beneficial effect of alcohol in reducing incidence of cardiovascular disease in people who consume low to moderate amounts of alcohol. However, this study found that greater alcohol consumption was negatively correlated with brain volume," said study author Carol Ann Paul, MS, of Wellesley College in Wellesley, MA.

This cross-sectional study found people who had more than 14 drinks per week had an average 1.6 percent reduction in the ratio of brain volume to skull size compared to people who didn't drink. In other words, brain volume decreased .25 percent on average for every increase in drinking category (i.e. non-drinkers, former drinkers, low drinkers, moderate drinkers, or high drinkers).

In addition, Paul reported the inverse relationship between drinking and brain volume was slightly larger in women than in men. Also, drinking heavy amounts of alcohol seemed to have the biggest negative impact on brain volume for women in their 70s.

In looking at the longitudinal effects of drinking, people who had a 12-year history of heavy drinking had less brain volume than those who changed into the high drinking group during those 12 years. R
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