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Drexel Research in Cytokines Could Treat Sepsis

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“The beauty and power of our technology is its ability to fine-tune the carbon microstructure and pore size to target a specific application,” says Yury Gogotsi, director of the A. J. Drexel Nanotechnology Institute (DNI) and a co-inventor of the technology. Gogotsi’s team and his collaborators from Brighton, led by Sergey Mikhalovsky, tested the new adsorbents for the removal of inflammatory cytokines from blood plasma and obtained very promising results. The nano-engineered adsorbents outperformed any other materials or methods in the efficiency of cytokine adsorption, and the results are comparable only to highly specific antibody-antigen interactions. The development of these materials could be a major step toward fighting severe sepsis.

Similar materials could be used for the selective adsorption of other large organic molecules and possibly viruses for other bio-related or medical applications. “Maybe one day we will be able to apply our technology to fight Hepatitis C or bird flu or HIV,” says Dr. Gleb Yushin, research assistant professor at the Drexel Nanotechnology Institute and lead author on the journal article that reports this work.

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