Dr. Scott Hammer of NewYork-Presbyterian Hospital and Columbia University Medical Center has led the development of two important new guidelines for treatment of HIV.// He is lead author and chair of the panel of the International AIDS Society--USA's (IAS-USA) recommendations for treatment of the disease in developed nations—presented on Aug. 13 at the 2006 International AIDS Conference in Toronto and published in the Aug. 16 Journal of the American Medical Association (JAMA). And he is chairman of the writing committee of new guidelines published by the World Health Organization (WHO) for public health response to the disease in developing nations.

IAS-USA Guidelines for HIV Treatment in Developed Nations.

The IAS-USA guidelines, designed for individual patient management, reflect advances in treatment, simplifying regimens and reducing side effects. Recent advances include the development of a one-a-day combination pill and the ability to fully suppress HIV even in patients with the drug-resistant virus using protease inhibitors or the drug enfuvitide.

"These guidelines for treating HIV patients with antiretroviral therapy (ART) are important for clinicians worldwide given the rapid evolution of knowledge, the complexity of the field, and the varied clinical situations in which these agents are used," says Dr. Hammer, who is the Harold C. Neu Professor and chief of the Division of Infectious Diseases at Columbia University Medical Center and NewYork-Presbyterian. He is also professor of epidemiology at Columbia's Mailman School of Public Health.

In the nearly two decades since the advent of antiretroviral therapy for HIV, 21 new agents in five drug classes have been approved; potent combination therapy has become a worldwide standard of care; and morbidity and mortality in the developed world have been substantially reduced. Balanced against this progress is the identification of major unpredicted toxic effects and r
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