Navigation Links
Doubling Plavix Dose Recommended Before Angioplasty

Never mind the side-effects of Plavix, (generic name clopidogrel), the popular anti-blood-clotting drug .

A new study reveals doubling the current recommended dose of Plavix to angioplasty patients, from 300 milligrams to 600, cut the combined risk of heart attack and cardiac death by half.

Dr. Anthony Abbate, an assistant professor of medicine at Virginia Commonwealth University says the higher dose did not increase the risk of serious bleeding, a major concern with Plavix.

Abbate and Dr. Giuseppe G. Biondi-Zoccai, an assistant professor of cardiology at the University of Turin in Italy had analyzed ten previous studies and covered 1,500 patients who had angioplasty. Most had either 300 milligrams or 600 milligrams of Plavix before the procedure.

"The evidence is very powerful," said Dr. Gregory Dehmer, president of the society and a professor of medicine at Texas A&M College of Medicine. "Although Plavix is powerful stuff, the meta-analysis did not find an excessive amount of bleeding. So we have a lower risk of myocardial infarction [heart attack] with no significant increase in adverse side effects."

The incidence of cardiac death or non-fatal heart attack was 50 percent lower in the following 30 days in those getting the higher dose of Plavix. Only 3.1 percent of those getting the 600-milligram dose had in-hospital heart attacks, compared to 6.4 percent of those getting the 300-milligram dose. The overall 30-day incidence of death or heart attack was 3.8 percent for the higher dose and 7.3 percent for the lower dose, according to the study.

"This research has important clinical and cost implications," Biondi-Zoccai said in a prepared statement.

Current guidelines by the American Heart Association, the American College of Cardiology and the Society for Cardiovascular Angiography and Interventions say that physicians should "strongly consider" giving 300 milligrams o f Plavix before angioplasty, a medical procedure to open narrowed or blocked blood vessels of the heart.

"Those guidelines are in the process of having an update," Dehmer said, adding that new guidelines are expected "in the next few months."

"In practical terms, many practitioners are concerned about the current recommendations," Dehmer said. "One concern is that should the patient require elective bypass surgery, does a higher dose of clopidogrel increase the risk of excessive bleeding?

"Also there is the bleeding risk. It is addressed in this meta-analysis, which shows very minimal potential downside," he added.

But the final word is not in yet, said Dr. Marc S. Sabatine, associate professor in the cardiovascular division of Brigham and Women's Hospital in Boston. That will come from a major international study, to include up to 14,000 angioplasty patients, which is still enrolling participants, he said.

The smaller studies included in the current meta-analysis aren't definitive, Sabatine said, because there can be "publication bias," meaning that studies showing a positive result are more likely to get into print.

Timing also plays a role in treatment, he noted. Plavix must be activated in the liver, which takes about six hours, so giving it earlier makes it more effective.

But even with those side considerations, "many laboratories are considering switching to 600 milligrams," Sabatine said.


Related medicine news :

1. Response to chemotherapy could be measured by Prostate-Specific Antigen Doubling Time
2. V P Singh Proposes Doubling Of Medical Seats
3. Surge of HIV Cases in Taiwan Prompts Doubling in Expenditure for HIV Prevention
4. PSA Doubling Predicts Prostate Cancer Recurrence
5. Bush Seeks Doubling of AIDS-fighting Funds
6. Plavix Gets FDA Okay for New Indication
7. Sanofi-Aventis Allows Thais To Make Plavix
8. Plavix Safe During and After Heart Bypass
9. In Early Epilepsy Delay in medications Recommended
10. Exercises Should Be Recommended During Pregnancy
11. Drug Herceptin To Be Recommended To All Breast Cancer Patients
Post Your Comments:

(Date:6/24/2016)... ... June 24, 2016 , ... The ... in Dallas that it will receive two significant new grants to support its ... PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists for ...
(Date:6/24/2016)... Diego, CA (PRWEB) , ... June 24, 2016 , ... ... with the American Cancer Society and the Road To Recovery® program to drive cancer ... to seniors and other adults to ensure the highest quality of life and ongoing ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... the Clinical Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. ... articles published in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... feeding the Frederick area economy by obtaining investment capital for emerging technology companies. ... 2½ years that have already resulted in more than a million dollars of ...
(Date:6/24/2016)... ... 24, 2016 , ... Today, MTI-GlobalStem, a provider of optimized ... difficult to transfect cells, announces its launch of the PluriQ™ G9™ Gene Editing ... is a complete system for culturing and transfecting human pluripotent stem cells ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... addition of the "Structural Electronics 2015-2025: Applications, ... In-Mold Electronics, Smart ... Integrated Photovoltaics Structural electronics involves ... as load-bearing, protective structures, replacing dumb structures such ...
(Date:6/24/2016)... India , June 24, 2016 ... Needles Market by Type (Standard Pen Needles, Safety Pen ... Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, ... by MarketsandMarkets, This report studies the market for the ... expected to reach USD 2.81 Billion by 2021 from ...
(Date:6/23/2016)... Research and Markets has announced the ... to 2022" report to their offering. ... patients with kidney failure, it replaces the function of kidneys ... blood and thus the treatment helps to keep the patient ... Increasing number of ESRD patients & substantial ...
Breaking Medicine Technology: