Navigation Links
Donor T Cells Change the Fate of Stem Cells in Transplantation

When a transplant patient suffers complications such as graft rejection or graft-versus-host disease, physicians attempt to stop the body's immune response by targeting// a patient's T cells.

In a new study, University of Illinois at Chicago College of Medicine researchers suggest there may be a way to prevent these complications before they occur. The study was published July 1 in the journal Blood.

Previous studies by these researchers found that T cells are stimulated by blood stem cells -- immature cells that have yet to differentiate into the various cell types of the blood.

In the new study, the researchers report finding unexpected two-way communication and stimulation between blood stem cells and T cells.

In laboratory and animal models, the UIC researchers showed that alloreactive T cells change the fate of blood stem cells and may themselves stimulate a strong immune response.

"Knowing what mechanisms cause this change in stem cells would allow us to test immunosuppressive drugs and different T cell subsets, potentially preventing or reducing graft-versus-host disease or rejection," said Dr. Damiano Rondelli, associate professor of hematology at UIC and lead author of the study.

Graft-versus-host disease occurs when white blood cells from the donor attack tissues of the recipient. It is a very serious complication after stem cell transplantation from related or unrelated donors and may represent a cause of death in 30 to 50 percent of patients.

Graft rejection occurs when the immune system of the recipient rejects the donated graft. It is the opposite of graft-versus-host disease, but the mechanisms are the same.

Rondelli suggests that a loop occurs between stem cells and the donor T cells, causing them to grow and become immune-stimulating cells, called antigen-presenting cells. These new cells stimulate more T cells, and they recruit new stem cells to become mo re antigen-presenting cells. The more they activate each other, the more the T cell response grows.

"The idea that graft-versus-host disease and rejection can be related to stem cell function is intriguing," said Rondelli. "We know that by blocking some molecules we might stop these complications, which may translate into better outcomes for transplant patients."

(Source: Newswise)
'"/>




Related medicine news :

1. Transfer Of Rabies Virus Possible From Organ Donor To Recipient
2. World Blood Donors Day on 14th June 2005
3. Kidney Donors Health Can Cause Anxiety Among Kidney Recipients
4. Strategies To Boost Living Donor Kidney Transplants
5. DNA Identity Mix-Up In Bone Marrow Donors, And Miscarriages Of Justice Involved
6. Anonymous Sperm Donor Traced On Internet
7. Declining Rates Of Sperm Donors Over The Past 5 Years
8. Relaxation In Donor’s Age for Blood Donation in Scotlan
9. Scottish Health Minister Launches Organ Donor Plan
10. Baby Born Through Frozen Donor Egg
11. Australia Witnesses A Fall In the Number of Organ Donors
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/31/2016)... ... , ... The Global Wellness Summit (GWS), an annual conference for ... wellness, travel, spa and beauty in Europe. The organization asked its partner experts in ... and researchers - to forecast where wellness is headed in Europe. Predictions range from ...
(Date:5/31/2016)... ... May 31, 2016 , ... Interest is on the ... tool and as an orthogonal tool for RNAi hit validation. A key reason may ... guide RNAs—allows rapid generation of CRISPR RNA (crRNA) collections in arrayed formats. , ...
(Date:5/31/2016)... ... , ... Dr. Charles A. Ditta attained his Doctor of Medical Dentistry Degree ... 1986, where he graduated in the top ten percentile of his class. Dr. Ditta ... He has been a member in good standing for thirty years in the American ...
(Date:5/30/2016)... ... May 30, 2016 , ... As the CDC relaxes its stance on traditional ... to keep their households lice free. , According to a May 26 article ... keep kids in the classroom despite the fact that they may be harboring an ...
(Date:5/29/2016)... ... ... Whole Health Supply is happy to announce the favorable reception of its ... new style of nail clipper has a wider jaw opening that is useful for ... actual handle is 2.5mm thick to accommodate the cutting force. This is the maximum ...
Breaking Medicine News(10 mins):
(Date:5/30/2016)... , May 30, 2016 ... H1 2016" market research report with comprehensive information ... with comparative analysis at various stages, therapeutics assessment ... of administration (RoA) and molecule type, along with ... It also reviews key players involved in the ...
(Date:5/27/2016)... 2016 Hutchison China MediTech ... on the highly lucrative global oncology and immunology ... potential first-in-class or best-in-class tyrosine kinase inhibitor (TKI) ... strategic partners. HCM,s profitable Chinese healthcare business continues ... expect progress of the mid-to-late-stage pipeline during 2016-17 ...
(Date:5/26/2016)... 2016 A key trend that ... emergence of new treatments. Cardax, a development stage life ... The therapy is expected to fulfil large unmet medical ... conducting studies to develop new treatments for osteoarthritis. One ... involved in osteoarthritis are being investigated, and early trials ...
Breaking Medicine Technology: