Navigation Links
Donor T Cells Change the Fate of Stem Cells in Transplantation

When a transplant patient suffers complications such as graft rejection or graft-versus-host disease, physicians attempt to stop the body's immune response by targeting// a patient's T cells.

In a new study, University of Illinois at Chicago College of Medicine researchers suggest there may be a way to prevent these complications before they occur. The study was published July 1 in the journal Blood.

Previous studies by these researchers found that T cells are stimulated by blood stem cells -- immature cells that have yet to differentiate into the various cell types of the blood.

In the new study, the researchers report finding unexpected two-way communication and stimulation between blood stem cells and T cells.

In laboratory and animal models, the UIC researchers showed that alloreactive T cells change the fate of blood stem cells and may themselves stimulate a strong immune response.

"Knowing what mechanisms cause this change in stem cells would allow us to test immunosuppressive drugs and different T cell subsets, potentially preventing or reducing graft-versus-host disease or rejection," said Dr. Damiano Rondelli, associate professor of hematology at UIC and lead author of the study.

Graft-versus-host disease occurs when white blood cells from the donor attack tissues of the recipient. It is a very serious complication after stem cell transplantation from related or unrelated donors and may represent a cause of death in 30 to 50 percent of patients.

Graft rejection occurs when the immune system of the recipient rejects the donated graft. It is the opposite of graft-versus-host disease, but the mechanisms are the same.

Rondelli suggests that a loop occurs between stem cells and the donor T cells, causing them to grow and become immune-stimulating cells, called antigen-presenting cells. These new cells stimulate more T cells, and they recruit new stem cells to become mo re antigen-presenting cells. The more they activate each other, the more the T cell response grows.

"The idea that graft-versus-host disease and rejection can be related to stem cell function is intriguing," said Rondelli. "We know that by blocking some molecules we might stop these complications, which may translate into better outcomes for transplant patients."

(Source: Newswise)
'"/>




Related medicine news :

1. Transfer Of Rabies Virus Possible From Organ Donor To Recipient
2. World Blood Donors Day on 14th June 2005
3. Kidney Donors Health Can Cause Anxiety Among Kidney Recipients
4. Strategies To Boost Living Donor Kidney Transplants
5. DNA Identity Mix-Up In Bone Marrow Donors, And Miscarriages Of Justice Involved
6. Anonymous Sperm Donor Traced On Internet
7. Declining Rates Of Sperm Donors Over The Past 5 Years
8. Relaxation In Donor’s Age for Blood Donation in Scotlan
9. Scottish Health Minister Launches Organ Donor Plan
10. Baby Born Through Frozen Donor Egg
11. Australia Witnesses A Fall In the Number of Organ Donors
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... Michigan (PRWEB) , ... June 26, 2016 , ... On ... as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle ... honor of the city’s history as home to some of the world’s leading providers ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... was developed to enhance the health of felines. The formula is all-natural and is ... herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus ...
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... TX (PRWEB) , ... June 25, 2016 , ... Austin ... of the American College of Mohs Surgery and to Dr. Russell Peckham for medical ... and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery ...
(Date:6/25/2016)... ... 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can ... CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn ... X . Simply select a ProHand generator and drag it above media or text ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016  MedSource announced today that it has ... solution of choice.  This latest decision demonstrates MedSource,s ... their clients by offering a state-of-the-art electronic data ... nowEDC as the EDC platform of choice in ... "nowEDC has long been a preferred EDC platform ...
(Date:6/23/2016)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that ... PCT (procalcitonin) assay as a dedicated testing solution for ... clearance, Roche is the first IVD company in the ... risk assessment and management. PCT is a ... in blood can aid clinicians in assessing the risk ...
(Date:6/23/2016)... , June 23, 2016 , ... on Thursday, July 7, 2016 , , , , LOCATION: ... , , , , EXPERT PANELISTS:  , , , ... Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and ... The global pharmaceutical industry is witnessing an exceptional era. ...
Breaking Medicine Technology: