Navigation Links
Dog (Man's best friend) Genome Sequenced

Researchers from Broad Institute of MIT and Harvard have published the entire genome sequence of dog (man's best friend). Human beings share similarity of their ancestral DNA with dogs// and the complete sequencing of the dog genome would provides a powerful tool for identifying genetic factors that contribute to human health and disease as both humans and dogs are mostly affected by cancers and the sequencing will help in identifying treatments for hereditary cancers.

The Researchers isolated the DNA sequence covering nearly 99 percent of the dog genome, from a female boxer named Tasha. The boxer was chosen as a representative of the average purebred dog to produce what has become a reference sequence for the dog genome community. Using the sequence information as a genetic "compass," they navigated the genomes of 10 different dog breeds and other related canine species, including the gray wolf and coyote. In this sampling, they pinpointed tiny spots of genetic variation, called single nucleotide polymorphisms (SNPs), which serve as recognizable signposts that can be used to locate the causes of genetic disease. Dr. Ostrander's laboratory maps genes responsible for cancer susceptibility in canines and humans, including breast and prostate cancers. In addition, Dr. Ostrander was the lead author of the white paper that provided the biomedical rationale for sequencing the dog genome.

The researchers found that the certain sequence in the gene of dogs were present as small elements that are crowded around just a small fraction of the genes in the genome. Future studies of these clusters may give scientists the critical insight needed to unravel how genomes work. Other interesting observations emerged from this cross-genome analysis. The international team of researchers also identified roughly 2.5 million single nucleotide polymorphisms (SNPs) sprinkled throughout the dog genome. SNPs are variations in the DNA code, some of which contribute to disea ses or the overall health of a dog. SNPs also can be used to create a set of coordinates with which to survey genetic changes, both within and across dog breeds. These efforts revealed that individual breeds have maintained a large amount of genetic variability, despite their long history of restrictive breeding. In practical terms, this means that future efforts to locate disease genes in dogs can be much narrower in scope than comparable human studies, requiring a smaller number of genetic markers and DNA samples collected from the blood or cheek from only a few hundred dogs.

Scientists in the canine genetics community worldwide are currently tackling this problem by applying the knowledge gained from SNP analysis to find disease genes. To this end, the dog-owner community is an essential collaborator. "We deeply appreciate the generous cooperation of individual dog owners and breeders, breed clubs and veterinary schools in providing blood samples for genetic analysis and disease gene mapping," said Dr. Lindblad-Toh, who is the paper's first author. "Without their interest and help we could not be doing this work."

Source: Eurekalert.

Related medicine news :

1. Human Genome Project Achieves Technological Triumph
2. Human Diseases May Have Clue In Human-Chimp Genome Difference
3. Race Based Genome Project Launched By Mexico
4. Decoding the Fungi Genome Will Save Millions of Lives.
5. Yeast Genome Unravels Genes Critical For Maintaining DNA Integrity
6. Unraveling the Secrets of MHC in Human Genome
7. NHGRI Aims To Sequence Primate Genomes
8. p53, the Guardian of Our Genome
9. Genome Code Cracked for Breast and Colon Cancers
10. Sea Urchin Genome Similar To Man And May Cure Diseases
11. Scientists Map Key Landmarks in Human Genome
Post Your Comments:

(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
(Date:6/24/2016)... Fla. (PRWEB) , ... June 24, 2016 , ... Global ... Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this recognition ... Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this year’s ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway ... call for a minimum wage raise to $12 an hour by 2020 and then adjusting ... restore the lost value of the minimum wage, assure the wage floor does not erode ...
(Date:6/24/2016)... New York, NY (PRWEB) , ... June 24, ... ... lifestyle publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as ... believes that “the most beautiful women in the world, and the most handsome ...
(Date:6/24/2016)... ... , ... National recruitment firm Slone Partners is pleased to announce ... experience, as Vice President of North American Capital Sales at HTG Molecular . ... sales team in the commercialization of the HTG EdgeSeq system and associated reagents in ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016  MedSource announced today ... its e-clinical software solution of choice.  This latest ... possible value to their clients by offering a ... preferred relationship establishes nowEDC as the EDC platform ... MedSource,s full-service clients.  "nowEDC has long been a ...
(Date:6/23/2016)... 23, 2016  In a startling report released today, National ... by lacking a comprehensive, proven plan to eliminate prescription opioid overdoses. ... of how states are tackling the worst drug crisis in recorded ... – Kentucky , New Mexico ... . Of the 28 failing states, three – Michigan ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... their offering. The current ... environment for MedImmune to enter. The US ageing population creates ... drive considerable growth for effective anti-influenza medications. The introduction of ... but development is still in its infancy. ...
Breaking Medicine Technology: