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Does Aspirin Crystallize?

to mean that a molecule can take on one or another packing arrangement in the crystalline state; a single crystal of a specific chemical substance is either one polymorph or the other.

Aspirin is the first case in which two different “polymorphic” structures exist in one single crystal. So is aspirin polymorphic or not? Should the definition of polymorphism be updated? Such questions are not just philosophical in nature, but could have tangible implications in patent law, because each polymorph of a compound is viewed as a separate patentable substance.

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