Navigation Links
Dividing Nerve Cells Could Trigger Alzheimer's Disease

A new study appearing in the January 18 issue of The Journal of Neuroscience, says that Alzheimer's disease (AD) could be triggered off when adult neurons try to undergo division. This finding in laboratory// mice could help scientists understand the mechanism behind the development of the disease.

"If you could stop cell cycling, you might be able to stop neurons from dying prematurely. This could be a fresh approach to therapy for Alzheimer's and other diseases, including stroke, amyotrophic lateral sclerosis [also known as Lou Gehrig's disease], and HIV dementia," said lead researcher Karl Herrup, Ph.D., of Case Western Reserve University in Cleveland. Neurons affected by Alzheimer's and other degenerative disease start to divide before they die. This cell division starts before the amyloid plaques that are distinctive to the disease start to appear. In the current study, researchers compared three different mouse models of AD to the brains of normal mice. They found that in the AD models, proteins related to cell cycle started appearing before amyloid plaques. Many of the neurons had increased chromosome number. The cortex and the hippocampus regions were the most affected in the lab mice. These are the same areas that are affected by AD. "The cell cycle markers mimic the human situation rather well," said Dr. Herrup. "This opens a range of new experimental possibilities using the cell cycle events as indicators of neuronal distress." His team is now working towards finding out if Ibuprofen can stop this neurodegenaration. Ibuprofen is a NSAID that decreases the production of amyloid beta and some studies have indicated that it could be beneficial in AD. This study was partly funded by National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.

Original Article: YangY, Varvel NH, Lamb BT, Herrup K. Ectopic cell cycle events link human Alzheimer's disease and APP transgenic mouse models. The J ournal of Neuroscience, January 18, 2005, Vol. 26, No. 3, pp. 775-784. Contact Natalie Frazin or Paul Girolami NIH/National Institute of Neurological Disorders and Stroke http://www.ninds.nih.gov
'"/>




Related medicine news :

1. Epilepsy Drug Helps Diabetic Nerve Damage
2. World’s First Nerve Stem Cells Produced
3. Children With Epilepsy Can Be Treated With Nerve Stimulation
4. FDA Approved Nerve-Stimulation Therapy Now Available In New York
5. Doctors Finish Mother-To-Son Nerve Surgery
6. Stem Cells From Hair Follicle To Repair Nerve Damage
7. Nerve regeneration for Spinal cord injuries
8. Novel Protein, Staufen2 Important In Maintenance Of Nerve Synapses
9. Protein Found to Be Essential For Maintaining Nerve Health
10. Nerve Stimulator for Depression Though Not Effective Was Given Approval
11. Nerve Damage Can Be Prevented By Xenon Administration During Surgery
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily ... of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures ... . Simply select a ProHand generator and drag it above media or text in ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published ... unfamiliar with. The article goes on to state that individuals are now more comfortable ... less common operations such as calf and cheek reduction. The Los Angeles area medical ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was ... his family verbally and physically. , “When something upset him, he couldn’t control his emotions,” ... He would throw rocks at my other children and say he was going to kill ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, ... treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including robotic ... osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016 Research and Markets has announced ... Diagnostic Tests" report to their offering. ... The World Market for Companion Diagnostics covers ... Market analysis in the report includes the following: ... Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
(Date:6/24/2016)... , Belgium , June 24, ... VNRX), today announced the appointment of Dr. ... Directors as a Non-Executive Director, effective June 23, ... Audit, Compensation and Nominations and Governance Committees.  As ... Futcher will provide independent expertise and strategic counsel ...
(Date:6/23/2016)... 2016 Research and Markets has announced ... Forecast to 2022" report to their offering. ... the patients with kidney failure, it replaces the function of ... patient,s blood and thus the treatment helps to keep the ... balance. Increasing number of ESRD patients & ...
Breaking Medicine Technology: