Navigation Links
Dividing Nerve Cells Could Trigger Alzheimer's Disease

A new study appearing in the January 18 issue of The Journal of Neuroscience, says that Alzheimer's disease (AD) could be triggered off when adult neurons try to undergo division. This finding in laboratory// mice could help scientists understand the mechanism behind the development of the disease.

"If you could stop cell cycling, you might be able to stop neurons from dying prematurely. This could be a fresh approach to therapy for Alzheimer's and other diseases, including stroke, amyotrophic lateral sclerosis [also known as Lou Gehrig's disease], and HIV dementia," said lead researcher Karl Herrup, Ph.D., of Case Western Reserve University in Cleveland. Neurons affected by Alzheimer's and other degenerative disease start to divide before they die. This cell division starts before the amyloid plaques that are distinctive to the disease start to appear. In the current study, researchers compared three different mouse models of AD to the brains of normal mice. They found that in the AD models, proteins related to cell cycle started appearing before amyloid plaques. Many of the neurons had increased chromosome number. The cortex and the hippocampus regions were the most affected in the lab mice. These are the same areas that are affected by AD. "The cell cycle markers mimic the human situation rather well," said Dr. Herrup. "This opens a range of new experimental possibilities using the cell cycle events as indicators of neuronal distress." His team is now working towards finding out if Ibuprofen can stop this neurodegenaration. Ibuprofen is a NSAID that decreases the production of amyloid beta and some studies have indicated that it could be beneficial in AD. This study was partly funded by National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.

Original Article: YangY, Varvel NH, Lamb BT, Herrup K. Ectopic cell cycle events link human Alzheimer's disease and APP transgenic mouse models. The J ournal of Neuroscience, January 18, 2005, Vol. 26, No. 3, pp. 775-784. Contact Natalie Frazin or Paul Girolami NIH/National Institute of Neurological Disorders and Stroke http://www.ninds.nih.gov
'"/>




Related medicine news :

1. Epilepsy Drug Helps Diabetic Nerve Damage
2. World’s First Nerve Stem Cells Produced
3. Children With Epilepsy Can Be Treated With Nerve Stimulation
4. FDA Approved Nerve-Stimulation Therapy Now Available In New York
5. Doctors Finish Mother-To-Son Nerve Surgery
6. Stem Cells From Hair Follicle To Repair Nerve Damage
7. Nerve regeneration for Spinal cord injuries
8. Novel Protein, Staufen2 Important In Maintenance Of Nerve Synapses
9. Protein Found to Be Essential For Maintaining Nerve Health
10. Nerve Stimulator for Depression Though Not Effective Was Given Approval
11. Nerve Damage Can Be Prevented By Xenon Administration During Surgery
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/27/2017)... ... , ... Elisa Guajardo Carothers is not your typical author. She went from working as a ... she writes about God, when she isn’t swimming as a performing mermaid. , Her book ... (Before Satan),” she offers a comedic look at the dysfunctions of God’s family, before Lucifer ...
(Date:2/27/2017)... , ... February 26, 2017 , ... Miro is the ... sound and video system brings songs, movies, TV shows and much more apps for ... clear, high-definition sound. An immersive view of 1280 x 720 provides crisp images with ...
(Date:2/27/2017)... ... 27, 2017 , ... Sunshine Coast Health Centre (SCHC), one ... at https://www.sunshinecoasthealthcentre.ca/ , is proud to announce the addition of a registered ... Centre's commitment to innovation in drug rehab and alcohol treatment strategies beyond a ...
(Date:2/27/2017)... (PRWEB) , ... February 27, 2017 , ... New Jersey ... rates, among all types and genders. And the need for advanced services is growing. ... and its top-rated cancer care program, in collaboration with their non-profit partners in their ...
(Date:2/26/2017)... ... February 26, 2017 , ... ... lab became the world’s first to be ISO/IEC 17025:2005 INAB accredited for Der ... , ISO/IEC 17025:2005 is the globally recognised standard that sets out requirements for ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... , Feb. 27, 2017   Vitasome ® ... of nutritional supplements using its groundbreaking new liposome technology. ... percent of potency through digestion per Physician,s Desk ... solve the problem of nutritional waste and are scientifically ... during digestive processes Improve bioavailability with ...
(Date:2/27/2017)...  Impax Laboratories, Inc. (NASDAQ: IPXL ) today announced that ... Raymond James and Associates, 38 th Annual ... Orlando, FL. Cowen and Company ... March 7, 2017 in Boston, MA. ... in Miami, FL. Individuals ...
(Date:2/27/2017)... -- Leading Countries, Technologies and Companies ... at a CAGR of 8.9% from 2016-2021 and CAGR of 9.2% ... of 9.1% from 2016 to 2027. The market is estimated at ... ... Read on to discover how you can exploit the future business ...
Breaking Medicine Technology: