Navigation Links
Dissecting Diabetes - Is protein AKT2 the cause of type 2 diabetes?

"This is a big step forward in dissecting the pathways and mechanisms of diabetes. It is fascinating." Yes the researchers of Yale University have seen a break through in the identification of the missing protein in the adult onset Type II Diabetes mellitus.

They have discovered that mice lacking a gene that produces the enzyme called Akt2 or Protein Kinase B are born without diabetes but develop symptoms of glucose intolerance after two months, roughly the same age that onset begins in humans.

Heading this mission of profound dimension Dr.Kim said that if studies in humans show that the lack of this protein has similar effects, the finding could lead to development of a therapeutic target for preventing Type-2 diabetes.//

This study is is supported by Dr. Morris Birnbaum, a Howard Hughes Medical Institute investigator at the University of Pennsylvania Medical school, who devised the "Akt2 knock out mice". In the knockout mice, they discovered a partial defect in insulin-stimulated glucose uptake in the animals' muscle tissue. Further studies showed that the liver of the Akt2 knockout mice did not respond to insulin by lowering glucose production, and their tissues were consuming less glucose in response to insulin.

"This defect in insulin action in the liver and skeletal muscle altered glucose homeostasis throughout the body. Combined with the delayed onset, (it) suggests that Akt2 might have a role in the diabetes. The researchers are correct in stating that the finding presents an opportunity to test potential targets for drug development and hence the gene therapy.

But for the difficulty in using human subjects in such research it is that most adults are unaware they are becoming glucose intolerant until they are diagnosed with Type 2 diabetes at their later age.

Let us hope that future collaborations between the Yale and University of Pennsylvania researc h teams will result in further understanding the disease.

"This is the future of how we will come to understand the pathology of diabetes."


'"/>




Related medicine news :

1. Is Diabetes the Leading Cause of Kidney Failure in India
2. Diabetes and Depression often go hand-in-hand
3. Thirty minutes of work up per day reduces the risk of Diabetes
4. Diabetes on the rise
5. Irregular Periods Linked to Diabetes
6. Cinnamon combats Diabetes
7. Good News For Women With Gestational Diabetes
8. Processed Meat, Diabetes connection Found
9. Pancreatic Cancer may be linked to Diabetes
10. Gestational Diabetes linked to Chromosomal defici
11. A way to slow the progression of Type 1 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/5/2016)... ... February 05, 2016 , ... Pivot Point Consulting, a leading ... Software & Services for HIT Implementation Support & Staffing report with an outstanding ... performance by healthcare executives, managers and clinicians representing over 4,500 hospitals and 2,500 ...
(Date:2/5/2016)... ... ... Stuart Bentkover, MD, FACS is thrilled to announce the arrival of ... removal today, Dr. Bentkover is the only doctor in Central Massachusetts to offer patients ... approved by the Food and Drug Administration (FDA) as a safe and efficient method ...
(Date:2/5/2016)... ... February 05, 2016 , ... In sleep, when the ... a dream. A hallmark feature of patients with eating disorders is significant self-criticism, and ... disorder behaviors and obsessions are regarded as maladaptive means for coping with this unease, ...
(Date:2/5/2016)... ... February 05, 2016 , ... On June ... Diseases, a continuing medical education (CME) event presented by the Association for Comprehensive ... a first for ACCORD, whose mission is to provide education, tools, and resources ...
(Date:2/5/2016)... ... February 05, 2016 , ... –This week, Atascadero water heater ... having a tankless water heater. To view the report, click here or ... tankless. While each has their pros and cons, the type chosen is almost entirely ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... Feb. 4, 2016 For hospitals considering enrollment ... already participating in the program, the Health Resources and ... as the , Mega-Guidance , could have significant impact ... published in September 2016. Essential Insights , ... Marketing , summarizes the Mega-Guidance,s key proposed changes, including ...
(Date:2/4/2016)... LONDON , Feb. 4, 2016 ... to achieve significant growth as next generation systems ... and use radiology for cancer surgery. New systems ... radiological overdosing that has been such a problem ... be delivered. Radiosurgery robots take cancer surgery far ...
(Date:2/4/2016)... Wegener Polyangiitis - Pipeline Review, H2 ... Polyangiitis - Pipeline Review, H2 2015, provides an ... This report provides comprehensive information on the therapeutic ... at various stages, therapeutics assessment by drug target, ... and molecule type, along with latest updates, and ...
Breaking Medicine Technology: