Navigation Links
Dissecting Diabetes - Is protein AKT2 the cause of type 2 diabetes?

"This is a big step forward in dissecting the pathways and mechanisms of diabetes. It is fascinating." Yes the researchers of Yale University have seen a break through in the identification of the missing protein in the adult onset Type II Diabetes mellitus.

They have discovered that mice lacking a gene that produces the enzyme called Akt2 or Protein Kinase B are born without diabetes but develop symptoms of glucose intolerance after two months, roughly the same age that onset begins in humans.

Heading this mission of profound dimension Dr.Kim said that if studies in humans show that the lack of this protein has similar effects, the finding could lead to development of a therapeutic target for preventing Type-2 diabetes.//

This study is is supported by Dr. Morris Birnbaum, a Howard Hughes Medical Institute investigator at the University of Pennsylvania Medical school, who devised the "Akt2 knock out mice". In the knockout mice, they discovered a partial defect in insulin-stimulated glucose uptake in the animals' muscle tissue. Further studies showed that the liver of the Akt2 knockout mice did not respond to insulin by lowering glucose production, and their tissues were consuming less glucose in response to insulin.

"This defect in insulin action in the liver and skeletal muscle altered glucose homeostasis throughout the body. Combined with the delayed onset, (it) suggests that Akt2 might have a role in the diabetes. The researchers are correct in stating that the finding presents an opportunity to test potential targets for drug development and hence the gene therapy.

But for the difficulty in using human subjects in such research it is that most adults are unaware they are becoming glucose intolerant until they are diagnosed with Type 2 diabetes at their later age.

Let us hope that future collaborations between the Yale and University of Pennsylvania researc h teams will result in further understanding the disease.

"This is the future of how we will come to understand the pathology of diabetes."


Related medicine news :

1. Is Diabetes the Leading Cause of Kidney Failure in India
2. Diabetes and Depression often go hand-in-hand
3. Thirty minutes of work up per day reduces the risk of Diabetes
4. Diabetes on the rise
5. Irregular Periods Linked to Diabetes
6. Cinnamon combats Diabetes
7. Good News For Women With Gestational Diabetes
8. Processed Meat, Diabetes connection Found
9. Pancreatic Cancer may be linked to Diabetes
10. Gestational Diabetes linked to Chromosomal defici
11. A way to slow the progression of Type 1 Diabetes
Post Your Comments:

(Date:11/27/2015)... ... November 27, 2015 , ... Consistent ... sharing, the 2016 Building Better Radiology Marketing Programs meeting will showcase ... Sunday, March 6, 2016, at Caesars Palace in Las Vegas with a pre-conference ...
(Date:11/27/2015)... ... 27, 2015 , ... The moment you stop improving is ... fulfilling the needs of advisers and clients but going above and beyond to ... customer service. However, there's always room for improvement, which is why the entire ...
(Date:11/27/2015)... ... 2015 , ... The men and women on this list ... the country. They have overseen financial turnarounds, shown commitment to their community through ... as a whole through their advocacy and professional efforts. , Becker's Hospital Review ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... contact center software Q-Suite, announces the incorporation of Asterisk 11 LTS (Long Term ... fully supported Asterisk 11 LTS brings Q-Suite 5.10 up-to-date with a version of ...
(Date:11/26/2015)... ON (PRWEB) , ... November 26, 2015 , ... ... of a real-time eReferral system for diagnostic imaging in the Waterloo region. Using ... BMD and Nuclear Medicine tests directly from their electronic medical record (EMR) without ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... India , November 26, 2015 ... --> adds ... Report" and "Investigation Report on China ... and 2021 forecasts data and information ... . ...
(Date:11/26/2015)... November 26, 2015 ... addition of the  "2016 Future Horizons ... Cell Surface Marker Testing Market: Supplier ... to their offering.  --> ... of the  "2016 Future Horizons and ...
(Date:11/25/2015)...  The American Academy of Pediatrics (AAP), American ... March of Dimes cheered today,s signature into law ... of 2015 (S.799), which takes much-needed strides ... to drugs, such as opioids, and to improve ... organizations have worked together leading advocacy efforts for ...
Breaking Medicine Technology: