Navigation Links
Discredited Drug may Be Used to Aid Mental Development in Down’s Syndrome Patient

Researchers who experimented with a drug used previously in the treatment of epilepsy are planning to extend the study from lab rats// to human subjects.

The researchers found that the drug called pentylenetetrazole, or PTZ, when administered daily to the rats which were bred to have genetic similarities to Down’s Syndrome patients, elicited marked improvement in learning abilities.

Down's syndrome is the most frequent genetic cause of mental retardation and occurs equally around the world, in about one in every 800 births. About 5,000 children born in the United States each year have Down syndrome.

It is caused by the presence of a third chromosome, known as chromosome 21. Most people have two copies of each chromosome and the additional activity of the genes on the third copy of chromosome 21 is believed to cause the symptoms of Down syndrome.

The researchers were led by Craig Garner, a professor of psychiatry and a director of the Down Syndrome Research Center at California's Stanford University and they published results in the journal Nature Neuroscience.

Fabian Fernandez, a student in Garner's lab, was exploring the possibility that the brains of Down's patients are too strongly affected by a chemical called GABA, a neurotransmitter, or message-carrying chemical. This stops brain cells from becoming too excited.

In general, learning involves neuronal excitation in certain parts of the brain.

Says Garner "For example, caffeine, which is a stimulant, can make us more attentive and aware, and enhance learning."

PTZ does this by causing more GABA to be available in the brain. Overdoing this process can cause seizures. PTZ was once used to study epilepsy but it is no longer approved for use in people.

Fernandez gave daily doses of PTZ to the mice for about 2 weeks.

The mice were better able to navigate mazes and recognize new objects after receiving the drug, and were on par with normal mice.

The gains continued for months after the treatment stopped. This makes the scientists believe that as it can cause long-term changes in the brain, it can probably be used as a psychotherapy drug.

Concludes Garner: We think we're slowly being able to understand what's causing reduced cognitive ability in people with Down syndrome and there are new approaches and strategies that could improve their quality of life.
ANN
'"/>




Related medicine news :

1. Link between Mercury based Vaccines and Autism Discredited
2. Mental illness a key factor in suicide
3. Mental retardation linked to brain protein
4. Mental growth in babies at risk
5. Reduced Fatigue Boosts Mental Health
6. Mental Health Services for Children
7. Mentally Demanding Jobs Found To Reduce The Risk Of Alzheimer’
8. Diabetics To Seek Mental Counseling To Cope With Stress
9. Exercise Can Decrease Mental Decline
10. Low Socioeconomic Status May Lead To Mental Illness
11. Mental health may deteriorate as early as in the teens
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/25/2017)... ... , ... Just ask anyone old enough to remember what it was like ... up and containing so much metal that jokes about radio reception abounded. But thanks ... barely be observed. As a result, it’s now a billion-dollar industry and is, in ...
(Date:9/25/2017)... ... September 25, 2017 , ... Tim Rial Agency of Burleson, TX announces the ... By working closely with nonprofit groups and community leaders, the agency hopes to bring ... worthy organizations, families and individuals. , Tim Rial, the owner of Tim Rial ...
(Date:9/25/2017)... ... September 25, 2017 , ... NCPDP Foundation ... that it has awarded a $40,000 grant to Johns Hopkins Medicine to address ... CancelRx enables prescribers to electronically cancel a prescription already submitted to a pharmacy. ...
(Date:9/25/2017)... ... September 25, 2017 , ... Bobbie Horowitz was hardly able ... multiple health issues. As a cabaret and theater producer, Horowitz would manage to get ... of transportation in New York City, so she had to take a cab everywhere. ...
(Date:9/25/2017)... Port Richey, FL (PRWEB) , ... September 25, 2017 , ... ... New Port Richey, Fla. location at 5304 Main Street as an interventional pain management ... of the spine and extremities. He joins PPOA from private practice In Brooksville, Fla. ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... , Sept. 6, 2017 NeuroRx, a clinical ... Suicidal Ideation and Behavior (ASIB), has been granted Fast Track ... sequential therapy of NRX-100 (ketamine HCl) followed by NRX-101 (D-cycloserine ... a pivotal trial of this sequential therapy targeting patients who ... 1 ...
(Date:9/5/2017)... 2017  Just 18 months after its February 2016 ... announce the appointment of three new senior people to ... Dominic Jones-Phillips and James Wright bring ... Tammy Wynne joins as ... writers. She has over ten years, experience in global ...
(Date:8/31/2017)... Aug. 31, 2017 PM360,s annual Innovations ... to the latest innovations happening across the industry. Established ... to focus on providing a comprehensive look at the ... covers the most innovative companies, startups, divisions, products, services, ... "Everyone in this industry wants to ...
Breaking Medicine Technology: