Navigation Links
Discredited Drug may Be Used to Aid Mental Development in Down’s Syndrome Patient

Researchers who experimented with a drug used previously in the treatment of epilepsy are planning to extend the study from lab rats// to human subjects.

The researchers found that the drug called pentylenetetrazole, or PTZ, when administered daily to the rats which were bred to have genetic similarities to Down’s Syndrome patients, elicited marked improvement in learning abilities.

Down's syndrome is the most frequent genetic cause of mental retardation and occurs equally around the world, in about one in every 800 births. About 5,000 children born in the United States each year have Down syndrome.

It is caused by the presence of a third chromosome, known as chromosome 21. Most people have two copies of each chromosome and the additional activity of the genes on the third copy of chromosome 21 is believed to cause the symptoms of Down syndrome.

The researchers were led by Craig Garner, a professor of psychiatry and a director of the Down Syndrome Research Center at California's Stanford University and they published results in the journal Nature Neuroscience.

Fabian Fernandez, a student in Garner's lab, was exploring the possibility that the brains of Down's patients are too strongly affected by a chemical called GABA, a neurotransmitter, or message-carrying chemical. This stops brain cells from becoming too excited.

In general, learning involves neuronal excitation in certain parts of the brain.

Says Garner "For example, caffeine, which is a stimulant, can make us more attentive and aware, and enhance learning."

PTZ does this by causing more GABA to be available in the brain. Overdoing this process can cause seizures. PTZ was once used to study epilepsy but it is no longer approved for use in people.

Fernandez gave daily doses of PTZ to the mice for about 2 weeks.

The mice were better able to navigate mazes and recognize new objects after receiving the drug, and were on par with normal mice.

The gains continued for months after the treatment stopped. This makes the scientists believe that as it can cause long-term changes in the brain, it can probably be used as a psychotherapy drug.

Concludes Garner: We think we're slowly being able to understand what's causing reduced cognitive ability in people with Down syndrome and there are new approaches and strategies that could improve their quality of life.
ANN
'"/>




Related medicine news :

1. Link between Mercury based Vaccines and Autism Discredited
2. Mental illness a key factor in suicide
3. Mental retardation linked to brain protein
4. Mental growth in babies at risk
5. Reduced Fatigue Boosts Mental Health
6. Mental Health Services for Children
7. Mentally Demanding Jobs Found To Reduce The Risk Of Alzheimer’
8. Diabetics To Seek Mental Counseling To Cope With Stress
9. Exercise Can Decrease Mental Decline
10. Low Socioeconomic Status May Lead To Mental Illness
11. Mental health may deteriorate as early as in the teens
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/27/2016)... ... May 27, 2016 , ... W.S. Badger Co. ... today that it has been recognized as one of the best small businesses for ... named as one of nine small businesses providing progressive benefits to new parents on ...
(Date:5/27/2016)... ... May 27, 2016 , ... In response to meager public ... unaware of the plight of aphasia. In collaboration with the American Aphasia Association, ... , The link between stroke and aphasia is relatively unknown, but through collaboration ...
(Date:5/27/2016)... ... May 27, 2016 , ... With a team of ... food industries. Aside from its GMP accreditation, Validation Center is also a registered ... products, services and staff. , Validation Center is ISO17025 accredited and only offers ...
(Date:5/26/2016)... ... 26, 2016 , ... Intalere, the healthcare industry leader in ... inaugural Member Conference at the Paris Hotel in Las Vegas, Nev., May 17-20, ... America’s healthcare providers. , The conference was highlighted by the announcement of the ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cardiac arrhythmia is a ... on long-term patient survival, reports a team of UPMC researchers in the largest ... the Journal of Thoracic and Cardiovascular Surgery, provide critical information that will hopefully ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... , May 27, 2016  A new study highlights the necessity of health literacy ... Journal of the American College of Radiology , a majority of oncology patients undergo ... Photo - http://photos.prnewswire.com/prnh/20160527/373022 ... ... Medical Diagnostic Imaging Ampronix ...
(Date:5/27/2016)... , May 27, 2016 LabStyle ... Dario™ Diabetes Management Tool, today announced that the Company,s Chief ... Marcum MicroCap Conference being held June 1-2 in ... being held June 7-9 in Los Angeles, CA. ... discuss recent corporate and operational milestones, including the U.S. FDA ...
(Date:5/27/2016)... According to the 2016 report, ... ambulatory blood pressure monitoring system market growth. With aging, ... to respond to different pressure rates, leading to hypertension ... various cardiovascular disorders such as heart failure, stroke, coronary ... growing in prevalence each year. WHO estimates that 17 ...
Breaking Medicine Technology: