Navigation Links
Discredited Drug may Be Used to Aid Mental Development in Down’s Syndrome Patient

Researchers who experimented with a drug used previously in the treatment of epilepsy are planning to extend the study from lab rats// to human subjects.

The researchers found that the drug called pentylenetetrazole, or PTZ, when administered daily to the rats which were bred to have genetic similarities to Down’s Syndrome patients, elicited marked improvement in learning abilities.

Down's syndrome is the most frequent genetic cause of mental retardation and occurs equally around the world, in about one in every 800 births. About 5,000 children born in the United States each year have Down syndrome.

It is caused by the presence of a third chromosome, known as chromosome 21. Most people have two copies of each chromosome and the additional activity of the genes on the third copy of chromosome 21 is believed to cause the symptoms of Down syndrome.

The researchers were led by Craig Garner, a professor of psychiatry and a director of the Down Syndrome Research Center at California's Stanford University and they published results in the journal Nature Neuroscience.

Fabian Fernandez, a student in Garner's lab, was exploring the possibility that the brains of Down's patients are too strongly affected by a chemical called GABA, a neurotransmitter, or message-carrying chemical. This stops brain cells from becoming too excited.

In general, learning involves neuronal excitation in certain parts of the brain.

Says Garner "For example, caffeine, which is a stimulant, can make us more attentive and aware, and enhance learning."

PTZ does this by causing more GABA to be available in the brain. Overdoing this process can cause seizures. PTZ was once used to study epilepsy but it is no longer approved for use in people.

Fernandez gave daily doses of PTZ to the mice for about 2 weeks.

The mice were better able to navigate mazes and recognize new objects after receiving the drug, and
'"/>




Page: 1 2

Related medicine news :

1. Link between Mercury based Vaccines and Autism Discredited
2. Mental illness a key factor in suicide
3. Mental retardation linked to brain protein
4. Mental growth in babies at risk
5. Reduced Fatigue Boosts Mental Health
6. Mental Health Services for Children
7. Mentally Demanding Jobs Found To Reduce The Risk Of Alzheimer’
8. Diabetics To Seek Mental Counseling To Cope With Stress
9. Exercise Can Decrease Mental Decline
10. Low Socioeconomic Status May Lead To Mental Illness
11. Mental health may deteriorate as early as in the teens
Post Your Comments:
(Date:10/22/2014)... October 22, 2014 Hay House is pleased ... Addiction and Upgrade Your Life (Paperback; $10.82) written by the ... & Recovery. This book is meant to help readers ... life of recovery. , Recovery 2.0 is not the ... Recovery 2.0 is a guide for what comes next. ...
(Date:10/22/2014)... Best Cheap Hosting USA is among the most ... recently announced that iPower ( http://www.best-cheap-hosting-usa.com/go/iPower/ ) is the ... the world. , “iPower is one of the most ... various kinds of useful products for new and old ... customer service and a number of features which will ...
(Date:10/22/2014)... Although there are only 24 hours in a ... who have trouble finding time within their busy schedules for exercise ... periods of time to get in shape. Here are five ways ... go. , Change Up Your Commute , Consider riding a ... some exercise into your daily routine. If you must use your ...
(Date:10/22/2014)... Akeso Biomedical, Inc. , a privately held ... infections, microbial biofilms, and chronic wounds, announced that Dr. ... , Dr. Sinskey is a Professor ... of Technology, or MIT. He has been a member ... holds positions as Co-Director of the Malaysia-MIT Biotechnology Partnership ...
(Date:10/22/2014)... TUESDAY, Oct. 21, 2014 (HealthDay News) -- Two sisters ... and heart damage. Ilina and Medha Krishen use ... for sounds of trouble in breathing patterns or heartbeats. ... School in Michigan, wanted to find a way to ... air pollutants. Using an electronic stethoscope, Ilina recorded one ...
Breaking Medicine News(10 mins):Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 2Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 3Health News:Best Cheap Hosting USA Has Recently Announced The Best Cheap Web Hosting Companies In 2014 2Health News:HealthGuideMD Presents Ways to Improve Your Exercise and Fitness 2Health News:Akeso Biomedical Appoints Dr. Anthony J. Sinskey to Board of Directors 2Health News:Teen Sisters Develop Ways to Measure Lung, Heart Damage 2
... - make rounds to assist those ... ... 700,dialysis patients requiring vital services benefited from the emergency,response efforts enacted by ... kidney care services, during the recent wildfires,affecting areas of Southern California. The ...
... Local residents show America how they ,Think About Their Drink, ST. LOUIS, ... prize winner of the Think About ... The Maples family entered the photo contest by submitting a ... As part of a ...
... they ,Think About Their Drink, NEW HAVEN, Conn., Oct. 29 , WHO: ... among the 25 winning families ... Drink Family Challenge from hundreds of entrants nationwide., WHAT: The ... submitting a creative snapshot of their gangs choosing ...
... 29, 2007 -- Another disease can be added ... Researchers have found that smoking increases the risk ... further, and the risk decreases only slowly after ... and Women,s Hospital, the Harvard School of Public ...
... physicians improve ... administrative burden., ANNAPOLIS, Md., Oct. 29 ... today announced the,introduction of CBayPraxis. (Logo: ... electronic patient folder, a simple,intuitive, and web enabled ...
... is marked by the breakdown of articular cartilage, which ... of most limb bones. It can afflict any ... as well as the weight-bearing knees and hips. ... affected joint. This inflammation has been attributed to ...
Cached Medicine News:Health News:DaVita Emergency Response Efforts Ensure Vital Treatment for More than 700 Kidney Failure Patients in Need of Life-Saving Dialysis Treatments in Areas Affected by Southern California Wildfires 2Health News:MilkPEP: St. Louis Family Wins Nationwide got milk? Contest 2Health News:MilkPEP: St. Louis Family Wins Nationwide got milk? Contest 3Health News:MilkPEP: New Haven Area Families Win Nationwide got milk? Contest 2Health News:MilkPEP: New Haven Area Families Win Nationwide got milk? Contest 3Health News:New study shows smoking increases risk of psoriasis 2Health News:CBaySystems Introduces CBayPraxis - A Breakthrough Solution Focused on Physician Practice Efficiency 2Health News:CBaySystems Introduces CBayPraxis - A Breakthrough Solution Focused on Physician Practice Efficiency 3Health News:CBaySystems Introduces CBayPraxis - A Breakthrough Solution Focused on Physician Practice Efficiency 4Health News:New insights into inflammation in osteoarthritis 2Health News:New insights into inflammation in osteoarthritis 3
(Date:10/22/2014)... , Oct 22, 2014 Antigen Discovery ... Irvine, California , announced the receipt of a ... Innovation Research award (SBIR) from the National Institute of Dental and ... the development of a Pan-HIV Protein Microarray Chip, which ... and HIV-2 subtypes and aid in the development of ...
(Date:10/22/2014)... 2014 Moms are ready to live the ... and their kids, according to the results of the ... Go Mobile for Moms, the latest installment in BabyCenter,s ... 1 pregnancy and parenting web and mobile destination worldwide, ... moms surveyed say they can,t think of a reason ...
(Date:10/22/2014)... , October 22, 2014 A ... Gloves Market (Product type, Form, End user, Application and ... Insights, Analysis, Research, Report, Opportunities, Segmentation and Forecast, 2013 ... gloves market. Based on key trends tracked, it is ... at $7.9 billion by 2020, registering a CAGR of ...
Breaking Medicine Technology:Biomarker Discovery Company, Antigen Discovery Inc., Awarded an NIH Phase I Small Business Innovation Research Grant to Develop a Pan-HIV Protein Microarray Chip 2BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 2BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 3BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 4Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 2Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 3Global Disposable Gloves Market Expected to Grow to $7.9 Billion by 2020 - Allied Market Research 4
... OvaGene Oncology Inc., a biotechnology company specializing in the development and ... opening of its new clinical and research laboratory in Irvine, ... for operations, research, and molecular clinical lab testing.   , ... The opening of the ...
... HARBIN, China , June ... Bulletin Board: WKBT) ("Weikang" or the,"Company"), a leading developer, ... and OTC pharmaceuticals and other,health and nutritional products in ... the Company had filed an application to list its ...
Cached Medicine Technology:OvaGene Oncology Opens New Innovative Gynecologic Cancer Laboratory and Research Facility 2Weikang Bio-Technology Announces Filing for NASDAQ Listing 2Weikang Bio-Technology Announces Filing for NASDAQ Listing 3
... kg, Interior Dimensions (WxDxH): 31.1 x 13.6 ... 44.6 x 22.4 x 20.5 cm, Capacity: ... - 300 x 35 mm bottles, 4 ... 1 - 240 x 80 mm bottle, ...
... The Minifold I system consists of four ... vacuum plenum, and metal clamping plate (see diagram). ... configurations for producing spots, dots, or slots (see ... be purchased as an accessory plate in conjunction ...
... Bio-Dot SF (slot format) microfiltration units provide ... nucleic acid in solution onto nitrocellulose or ... accommodated by using interchangeable templates to form ... format Bio-Dot SF apparatus. Each is available ...
... SF (slot format) microfiltration units provide a ... acid in solution onto nitrocellulose or Zeta-Probe ... by using interchangeable templates to form the ... Bio-Dot SF apparatus. Each is available as ...
Medicine Products: