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Discovery of A New Genetic Pathway Could Lead To Treatment Of Skin Problems And Cancer

Researchers discover the genetic pathway that could help in the eventually help in the treatment of skin problems and cancer.//

The researchers from the Oregon Health & Science University have succeeded in exposing a pathway by which demonstrates as to how a genes over-expression causes skin stem cells to change over from creating hair follicles to creating sebaceous glands.

The results of the discovery by the laboratory of Xiao-Jing Wang, M.D., Ph.D., professor of otolaryngology/head and neck surgery, OHSU School of Medicine, and member of the OHSU Cancer Institute, which is to be published in the latest issue of the journal Developmental Cell, explains that the new pathway that could one day be used as a therapeutic target for not only treating hair loss and oily skin, but also for the prevention and treatment of cancer.

The study's results are published Epidermal stem cells give rise to the outer layer of the skin that serves as a barrier for the body, as well as follicles that produce hairs and sebaceous glands that produce lipid oil to lubricate the skin. In aged skin, a protein called Smad7 is overproduced, which triggers hair loss and sebaceous gland growth.

The Developmental Cell study is the first to definitively link Smad7 over-expression and the pathological changes that occur in aged skin.

'In humans, scientists and medical doctors documented the aging skin phenotype a long time ago, and the Smad7 over-expression in aged skin was reported a few years ago, but nobody knew whether these two events had any link,' said Wang, who also serves in the OHSU departments of Cell and Developmental Biology, and Dermatology. 'We found the mechanism that links these two together.'

For their study, the researchers created genetically engineered mice in which Smad7 is expressed in the skin, including epidermal stem cells, with the expression level comparable to aged skin. They found that Smad7 over
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