Navigation Links
Discovery of A New Genetic Pathway Could Lead To Treatment Of Skin Problems And Cancer

Researchers discover the genetic pathway that could help in the eventually help in the treatment of skin problems and cancer.//

The researchers from the Oregon Health & Science University have succeeded in exposing a pathway by which demonstrates as to how a genes over-expression causes skin stem cells to change over from creating hair follicles to creating sebaceous glands.

The results of the discovery by the laboratory of Xiao-Jing Wang, M.D., Ph.D., professor of otolaryngology/head and neck surgery, OHSU School of Medicine, and member of the OHSU Cancer Institute, which is to be published in the latest issue of the journal Developmental Cell, explains that the new pathway that could one day be used as a therapeutic target for not only treating hair loss and oily skin, but also for the prevention and treatment of cancer.

The study's results are published Epidermal stem cells give rise to the outer layer of the skin that serves as a barrier for the body, as well as follicles that produce hairs and sebaceous glands that produce lipid oil to lubricate the skin. In aged skin, a protein called Smad7 is overproduced, which triggers hair loss and sebaceous gland growth.

The Developmental Cell study is the first to definitively link Smad7 over-expression and the pathological changes that occur in aged skin.

'In humans, scientists and medical doctors documented the aging skin phenotype a long time ago, and the Smad7 over-expression in aged skin was reported a few years ago, but nobody knew whether these two events had any link,' said Wang, who also serves in the OHSU departments of Cell and Developmental Biology, and Dermatology. 'We found the mechanism that links these two together.'

For their study, the researchers created genetically engineered mice in which Smad7 is expressed in the skin, including epidermal stem cells, with the expression level comparable to aged skin. They found that Smad7 over -expression shifts the epidermal stem cell differentiation program from forming hair follicles to sebaceous glands, causing the mice to exhibit balding and oily skin.

Surprising to the researchers was that, independent of its normal role in blocking signalling from a group of genes called Smad, Smad7 shuts down signalling of another group of genes called Wnt, by binding to a Wnt signalling protein known as Beta-catenin and degrading it with an enzyme called Smurf2. Wnt signalling is critical for organ development, but if Wnt signalling is too active, it also causes cancer.

'Our study identifies a new Beta-catenin degradation pathway,' the scientists said in the study. 'This finding has a significant impact not only on skin development and diseases, but also on diseases and cancers in other organs.'

For example, enhanced Beta-catenin signalling contributes to many cancer types, including those of the colon, lung and brain. The researchers believe inducing over-expression of Smad7 or delivery of Smad7 directly to tumour cells would provide a therapeutic approach because of the boost in Beta-catenin degradation.

However, impaired Beta-catenin signalling contributes to neurodegeneration, such as that caused by Alzheimer's disease, retina degeneration, bone density defect and aging. For these diseases, blocking Smad7-mediated Beta-catenin degradation may offer a therapeutic approach.

Source-Eurekalert
VIK
'"/>




Related medicine news :

1. Discovery of bone gene
2. New Discovery May Help Treat Infertility
3. New Discovery to Increase Survival of Breast cancer Patients
4. Discovery of World’s smallest laser
5. Discovery of a built-in fat sensor
6. OHSU Researchers Announce New Discovery
7. Discovery Of New Molecule Could Solve Cancer Spread Mystery
8. Discovery Of Human Skeletons Could Unfold Facts About By-Gone Ages
9. New Discovery Shows That Brain Could repair Itself After Stroke
10. New Sleep Gene Discovery Wakes Up Scientists
11. Discovery of Elevated Amyloid Peptide levels could lead to Alzheimer’s Preventio
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/6/2016)... York (PRWEB) , ... May 06, 2016 , ... A wide variety of national pet ... Events Home, Garden and Safety Media Showcase Wednesday, May 18 from noon to 8 p.m. ... offers a sneak peek at new and established home, garden, outdoor and safety pet products ...
(Date:5/6/2016)... (PRWEB) , ... May 06, 2016 , ... Logically, spring ... other seasons, when the weather is too cold, dry or hot, water on the ... can actually absorb moisture from the surrounding air. There’s only one problem, according to ...
(Date:5/6/2016)... ... ... is a speaker, author, and life strategy coach who is spreading the message of his ... publisher Strategic Book Group and its subsidiary Publish on Demand Global (PODG). , ... needed a heart and double-lung transplant. From this came a life-changing transformation that led him ...
(Date:5/6/2016)... ... ... Hawkins, Pastor and Overseer at The House of Yahweh, has written a new article this ... about helping to stop cancer. Yisrayl says there are too many suffering and dying from ... science industries will pay close attention and take action. The Pastor says that the root ...
(Date:5/6/2016)... ... May 06, 2016 , ... Kenneth Cochran, DSc, RN, FACHE, ... of the South announced today that Dr. Robert Menuet, Interventional Cardiologist with Cardiovascular ... Ultrasound Guided Coronary Atherectomy. , This procedure involves the removal of ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... 3, 2016   BIOTRONIK , a leader ... Food and Drug Administration (FDA) approval of Iperia ... heart failure patients with access to diagnostic magnetic ... remote monitoring with daily automatic transmission and closed ... in response to physiological demands. ...
(Date:5/3/2016)... , May 3, 2016   BIOTRONIK will ... extending care beyond the implant at the Heart Rhythm ... in San Francisco . ... the highest quality of patient care and satisfaction possible. ... for each and every tomorrow," said Marlou Janssen ...
(Date:5/3/2016)... , May 3, 2016 Pharmaceutical ... $55 million to a woman who says its talc-based ... awarded Gloria Ristesund $5 million in compensatory ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ... against the company. In February, the same court awarded ...
Breaking Medicine Technology: