Navigation Links
Discovery Leads to Way to Curb Anthrax Effect

Researchers have found a mechanism that anthrax bacteria use to elude the body’s defenses, which could lead to a drug or therapy// to lessen the effect of anthrax bacterial species Bacillus anthracis if used in a bioterrorism attack.

For the last four years, Dr. Rowe Byers, professor of microbiology, and Dr. Jean Arceneaux, associate professor of microbiology, have worked on the project that led to this discovery with scientists from the University of California,Berkeley and the Fred Hutchinson Cancer Research Center in Seattle. Assisting Byers and Arceneaux at UMC were Dr. Bianca Garner, currently a postdoctoral fellow in the Department of Medicine and Melissa Wilson, a graduate student in the Department of Microbiology.

A study of how bacteria steal iron from the body uncovered the mechanism that makes an end run around the body’s defense system. Byers said almost everything requires iron, even the anthrax organism.

“Organisms that cause infections have to find a way to get it from their hosts, in this case, humans. There is essentially no free iron available to a pathogen in a normal host. All of the host’s iron is functioning in enzymes or heme containing proteins, or is safely stored, with a small amount in transit bound to a protein called transferrin. Pathogenic bacteria like anthrax must tap into our normal iron flow to grow,” he said.

Bacteria have several means to capture iron from a host. Production of iron binding agents called siderophores is one of the mechanisms by which bacteria take iron away from the body. In response, the body makes a protein called siderocalin, which binds and inactivates some siderophores.

Siderocalin is a major and recently discovered pillar of the host’s innate defense system against infectious diseases, Byers said.

On the other side of this tug-of-war over iron is the anthrax organism, which produces a unique siderophore, called petrobactin. It was first discovered in anthrax by the UMC group. Petrobactin is not bound by host siderocalin so its iron gathering ability isn’t stopped by the body’s production of siderocalin, thus enabling petrobactin to steal iron from the body. It’s referred to as the “stealth” siderophore.

“It evades detection, just like a stealth bomber. It gives anthrax a way to capture iron from the host,” Arceneaux said.

At this time, the only pathogenic bacteria known to produce the unusual siderophore petrobactin are anthrax and one of its close relatives.

“The idea is if you had a way to block or prevent production of petrobactin with some drug or therapy then you would have an antianthrax strategy that would be an effective way to treat infection. That is one reason this has been exciting,” Byers said.

The research also could lead to a way of detecting purposeful release of anthrax. If petrobactin is found, then there’s a presumption there was an anthrax attack with a bioweapon.

UMC has a Level 3 anthrax research laboratory and the exclusive ability of the UMC research group to produce petrobactin from Bacillus anthracis is one of the reasons why UC-Berkeley collaborated on the project. Everyone working in the lab here had to submit to an FBI profile and the laboratory had to be approved by the Centers for Disease Control. Great precautions are taken to ensure the safety of the lab and the MedicalCenter and to provide security for the agent of bioterrorism.

The mail attacks with anthrax spores at the U.S. Senate and in New York confirmed the importance of the research. Arceneaux said the researchers began studying the iron acquisition system of anthrax because few others were doing it.

“One reason it hadn’t been studied much was because anthrax is rare in humans. It wasn’t until it was realized that it could be used as a bioweapon causing mass infections that interest peaked,” she said.

Source-Bio-Bi Technology
SRM
'"/>




Related medicine news :

1. Discovery of bone gene
2. New Discovery May Help Treat Infertility
3. New Discovery to Increase Survival of Breast cancer Patients
4. Discovery of World’s smallest laser
5. Discovery of a built-in fat sensor
6. OHSU Researchers Announce New Discovery
7. Discovery Of New Molecule Could Solve Cancer Spread Mystery
8. Discovery Of Human Skeletons Could Unfold Facts About By-Gone Ages
9. New Discovery Shows That Brain Could repair Itself After Stroke
10. New Sleep Gene Discovery Wakes Up Scientists
11. Discovery of Elevated Amyloid Peptide levels could lead to Alzheimer’s Preventio
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the ... AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in ... topics including advance care planning, healthcare costs and patient and family engagement. , ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe ... from the David Geffen School of Medicine at UCLA. He trained in Internal Medicine ... his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events ... turn to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. ... tools for healthy coping following a traumatic event. , Trauma sufferers tend to feel ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon and the ... in the world, and the most handsome men, look naturally attractive. Plastic surgery ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the ... to 2022" report to their offering. ... patients with kidney failure, it replaces the function of kidneys ... blood and thus the treatment helps to keep the patient ... Increasing number of ESRD patients & substantial ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Global MEMS Devices Medical Market Analysis 2016 - Forecast to ... The report contains up to date financial ... reliable analysis. Assessment of major trends with potential impact on ... dive analysis of market segmentation which comprises of sub markets, ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 ... Tomorrow,s Leaders Scholarship is any indication, the future is ... online at www.diabetesscholars.org by the Diabetes Scholars ... in the way of academic and community service excellence. ... program since 2012, and continues to advocate for people ...
Breaking Medicine Technology: