Navigation Links
Discovery In "Bubble Boy" Disease Gene Therapy

ren to develop full immune systems. However, three of the patients eventually developed leukemia, an event that caused the field of gene therapy to reconsider the safety of this approach.

Researchers later determined that the gamma C gene added to the stem cells had inserted itself into oncogenes (cancer-causing genes). The genetic on-switch that was part of the gamma C gene had turned on the oncogenes in the blood cells and caused them to multiply uncontrollably, causing leukemia. To study this complication of gene therapy, Sorrentino's group developed a mouse model that lacked the gene for gamma C (gamma C-/-) as well as Arf (Arf -/-). Arf is an important "tumor-suppressor" gene that forces cells that multiply abnormally fast to commit suicide. By using a mouse lacking Arf, the team ensured that leukemia caused by gene therapy in this model would not be suppressed by the gene's activity.

The researchers removed bone marrow stem cells from these new mouse models (Arf -/- gamma C -/- ) and inserted gamma C into them using specially modified viruses called vectors. The researchers then infused the treated cells back into the XSCID mice. The gene therapy cured the genetic disease, but 13 out of 15 of the treated XSCID mice went on to develop leukemia, the researchers reported. The team removed leukemic cells from mice that developed cancer and found that gamma C genes had inserted themselves into a variety of oncogenes.

In another experiment, the St. Jude investigators used mouse models that lacked Arf but had normal gamma C genes and therefore did not have XSCID. The team used this model to determine whether gene therapy would cause cancer even if a mouse model did not have XSCID. The researchers found that the rate of cancer development in non-XSCID mice getting gene therapy was significantly lower than among mice that had XSCID. "This finding suggests the presence of XSCID disease is a strong risk factor for developing leukemia fr
'"/>




Page: 1 2 3 4

Related medicine news :

1. Discovery of bone gene
2. New Discovery May Help Treat Infertility
3. New Discovery to Increase Survival of Breast cancer Patients
4. Discovery of World’s smallest laser
5. Discovery of a built-in fat sensor
6. OHSU Researchers Announce New Discovery
7. Discovery Of New Molecule Could Solve Cancer Spread Mystery
8. Discovery Of Human Skeletons Could Unfold Facts About By-Gone Ages
9. New Discovery Shows That Brain Could repair Itself After Stroke
10. New Sleep Gene Discovery Wakes Up Scientists
11. Discovery of Elevated Amyloid Peptide levels could lead to Alzheimer’s Preventio
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Discovery Bubble Boy Disease Gene Therapy

(Date:8/28/2014)... 28, 2014 Now in its 4th year, ... started in 2011 by two brain aneurysm survivors. The ongoing ... awareness, provide education to help increase early detection and to ... a brain aneurysm. We hope that you will be able ... at the 4th Annual Step for Hope Run/ Walk on ...
(Date:8/28/2014)... MMAR Medical is pleased to announce their ... regular customers to enjoy several perks and benefits when ... wholesale license. It’s a great choice for independent athletes, ... who regularly purchase medical braces but could use a ... active lifestyle or those of your club, group or ...
(Date:8/28/2014)... 28, 2014 The revenue cycle process ... from the time a patient books an appointment with ... provide final payments for services rendered to the healthcare ... billing service has the RCM process down to a ... computers become common place in nearly every healthcare facility ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 UniVoIP, Inc, ... El Segundo, CA, today announced that they have been ... of Los Angeles Local Small Business Enterprise (Local SBE) ... and certified by the state of California and LA ... Cloud-hosted Telephony Solution to governmental agencies throughout ...
(Date:8/27/2014)... (PRWEB) August 28, 2014 Author and ... iUniverse) takes readers on the thrilling adventures of sharp ... published in 2012, is gearing up for a new ... Split into two novellas , “Prescription: Murder” follows ... who finds himself dodging assassination attempts and thwarting criminals. ...
Breaking Medicine News(10 mins):Health News:Step for Hope and Raise Brain Aneurysm Awareness 2Health News:MMAR Medical Announces Customer Membership Program 2Health News:Tips on Automating the Revenue Cycle Process with Medical Billing 2Health News:Tips on Automating the Revenue Cycle Process with Medical Billing 3Health News:Cloud PBX Provider UniVoIP Gets Certified by the State of California and the County of Los Angeles Under the Local Small Business Enterprise (SBE) Preference Program 2Health News:William H. Simon Launches New Marketing Campaign for Book 2
... the brain called the choroid plexus that ostensibly possesses ... protein, associated with Alzheimer’s disease.// ,The ... protein, called beta-amyloid, and prevents it from accumulating in ... cord. Wei Zheng, an associate professor in the School ...
... a recent research, Angina, a from of heart disease that ... the fair sex//. Angina can cause heart attacks. ,Angina ... triggered by deficiency in oxygen that is carried to the ... narrowing of coronary arteries. Exercise, cold or emotional stress can ...
... on the newer medications for diabetics had a slightly ... and $1,760 less on annual total healthcare costs. ... the Merrell Dow professor of pharmacy at Ohio State ... data on patients who took thiazolidinediones (TZDs) or either ...
... breast cancer found a savior in her daughter, who helped ... Herceptin could be made available for her to fight debilitating ... the cancer drug to Mrs. Morgan, of Whitchurch. Katie Morgan, ... Owen Paterson, and expressed her mother’s condition, petitioning for humanitarian ...
... one of the deadliest diseases in UK. Symptoms include a ... to rush to the loo//. ,Hence DUP MP ... awareness about prostate cancer. Prostate cancer kills 220 men in ... ,Mr Campbell has won the support of 55 ...
... to sleep more and more and just can’t seem to ... the University of Athens//, one among four adults and one ... of snooze time every night. ,Psychiatry professor and head ... “We spend 20 percent less time sleeping now than 100 ...
Cached Medicine News:Health News:Angina Risks Pronounced In Women over 45 2Health News:New Diabetic Drugs More Effective than Older Ones 2
(Date:8/27/2014)... , Aug. 27, 2014 Decision Resources Group ... the Memphis health system and ... clinical integration, with rivals Methodist Le Bonheur Healthcare and ... groups to coordinate patient care. In addition, a national ... the most health plan enrollment in the ...
(Date:8/27/2014)... 2014 ResearchMoz presents this most ... Market Outlook to 2020. New report, "United States Laparoscopes ... the United States Laparoscopes market . The report ... units) and average prices (in US dollars) within market ... Tip Video Laparoscopes), Robotic Surgical Systems and Rigid Tip ...
(Date:8/27/2014)... WASHINGTON , Aug. 27, 2014 An experimental ... promise as a viable first treatment for anemia of inflammation, ... of the treatment published online today in Blood ... Hematology (ASH).    Anemia is a condition ... or do not function properly. When an individual has anemia, ...
Breaking Medicine Technology:Memphis-area Health Systems Turn Attention to Clinical Integration 2United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 2United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 3United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 4United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 5Drug Represents First Potential Treatment for Common Anemia 2Drug Represents First Potential Treatment for Common Anemia 3
... 11 BioStorage Technologies, a global leader in ... for the pharmaceutical and biotechnology industries, has expanded ... preparation services, including sample aliquoting and nucleic acid ... for comprehensive sample management continues to grow, BioStorage ...
... Oct. 11 CEL-SCI Corp. (Amex: CVM ) ... Virtual ConferenceWhen: , October 13, 2010 @ 11:30 AM ... the Internet -- Simply log on to the web at ... If you are unable to participate during the live webcast, ...
Cached Medicine Technology:Industry Leader BioStorage Technologies Broadens Sample Management Operations to Include Laboratory Sample Preparation Services 2
The perfect quick consult for the busy cardiologist, The Ultimate Echo Guide puts the most clinically essential information in an easy access format....
... a quick-lookup reference for ECG interpretation ... presents the basics (anatomy and physiology ... system of the heart, basic ECG ... algorithms, emergency medications, and comprehensive information ...
Dx/Rx: Heart Failure has tables and figures that summarize important clinical data and current professional society recommendations and up-to-date information for diagnosis and treatment of Heart Fai...
Topics include: ECG reading, ACLS (all the latest protocols and pearls), CHF, acute MI, cardiac testing, palpitations, pericarditis, arrhythmias, murmurs, athletes, valvular disease, endocarditis, sy...
Medicine Products: