Navigation Links
Discerning Sour Taste

A team headed by biologists from the University of California, San Diego has found that the cells and protein responsible to pick up the ‘sour’ taste,// which is the key sensor in the cerebro-spinal fluid.

The study, featured on the cover of the August 24 issue of the journal Nature, reports that each of the five basic tastes is detected by distinct taste receptors—proteins that detect taste molecules—in distinct cells. The team previously discovered the sweet, bitter and umami (savory) receptors and showed that they are found in separate cells, but some researchers have argued that sour and salty tastes, which depend on the detection of ions, would not be wired in the same way.

“Our results show that each of the five basic taste qualities is exquisitely segregated into different taste cells” explained Charles Zuker, a professor of biology at UCSD and a Howard Hughes Medical Institute Investigator, who headed the study. “Taken together, our work has also shown that all taste qualities are found in all areas of the tongue, in contrast with the popular view that different tastes map to different areas of the tongue.”

Tongue with bitter, sweet and umami To determine if the taste cells and receptors for sour were separate from the receptors for the other basic tastes, the researchers tested mice in which they had genetically ablated the cells containing the sour taste receptors. The mice could not taste sour, but had completely normal sweet, bitter, umami and salty tastes. Therefore, although the salt taste receptor has not yet been discovered, it and the four identified receptors must each be segregated into distinct taste cells.

In addition to being found in the taste buds, the researchers discovered that the sour protein receptor, PKD2L1, is also found along the entire length of the spinal cord in nerve cells that surround and reach into the central canal. Because sourness is a reflection of the acidity, or the pH of a solution, the researchers suspected that the spinal neurons with PKD2L1 might be responsible for monitoring the pH of the cerebrospinal fluid.

Electrical recordings taken from these spinal neurons showed that they were able to detect and respond to very small changes in pH, confirming their role as pH detectors. “There have been many claims for pH detectors that monitor the health of different body fluids, but the nature of the circuit and the receptors has been unknown,” said Zuker. “Therefore it is significant to discover that the same protein that detects sour tastes also functions as a sentinel of pH in the central nervous system.”

To discover the sour taste receptor, the researchers first turned to bioinformatics. According to Angela Huang, a graduate student working with Zuker and the lead author of the Nature paper, they started with three simple assumptions and then hunted the entire genome.

“First, we expected the taste receptors to be embedded in the cell membrane where they could be in contact with taste molecules on the tongue,” explained Huang. “Therefore, we narrowed the search down to genes for proteins with a structure that would allow them to be in a cell membrane. Second, we ruled out candidates that were found in many different tissues and focused on those mainly in the taste cells. Third, we looked for a candidate that was made in select populations of taste cells, rather than all taste cells.”

The three assumptions resulted in just a handful of possible candidates. PKD2L1 stood out because it was strongly produced in select cells in all of the different types of taste buds. PKD2L1 is a member of a family of proteins called polycystic-kidney-disease-like ion channels. Mutations in some members of this protein family lead to kidney failure, but according to Zuker, the cause of failure has been an open mystery.

“We don’t know if the other members of the protein family work in the same way as PKD2L1, but our findings could be an exciting and unexpected entry into understanding these devastating kidney disorders,” he said.

In addition to Zuker and Huang, the contributors to the study were Nicholas Ryba and Mark Hoon at NIDCR and Xiaoke Chen, Jayaram Chandrashekar, Wei Guo and Dimitri Tr?nkner at UCSD.

The study was supported by the HHMI and grants from the National Institutes on Deafness and Other Communication Disorders, the NIDCR, the Human Frontiers Science program and the Deutsche Forschungsgemeinschaft

Source : Eurea Alert


'"/>




Related medicine news :

1. Hunger Found To Influence Taste
2. Understanding The Link Between Hunger and Taste
3. Understanding The Role Of Olfaction In Taste
4. More About The Coffee Bean Than Just A Heavenly Taste and Smell
5. Cocoa: Doesn’t Taste Like Red Wine But Has Benefits Like It
6. Punjabis Transfer Taste From Chicken To Prawns
7. Genetic Variation In Bitter-Taste Receptor Gene Increases Alcoholic Risk
8. Functional Taste Cells Cultured In Vitro
9. Twins Taste Trend Inherited – Research Say
10. Sensitive Taste Buds Can Be The Blame for LilOne Not Eating Vegetables
11. Sour Taste Sensors Identified
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/26/2017)... ... April 26, 2017 , ... Elisabete Miranda, ... been honored by Enterprising Women magazine as one of its 2017 Enterprising Women ... business owners. Winners have demonstrated that they have fast-growth businesses, mentor or actively ...
(Date:4/26/2017)... ... April 26, 2017 , ... Miami native and local periodontist ... “I could have never imagined back in 1991 that this journey would have taken ... Over the last 25 years, Dr. Gallardo has pioneered implant dentistry innovation, evolving into ...
(Date:4/26/2017)... ... April 26, 2017 , ... New ... profitability of ready-to-drink, high-protein beverages by helping beverage manufacturers more effectively manage protein ... providing direct cost savings as well as more stable pricing over time. Now ...
(Date:4/25/2017)... ... April 25, 2017 , ... Bellus Medical, a leader ... in a new class of photodynamic cosmetics (PDC). , Allumera® is the first ... outward signs of aging, and minimize the appearance of pores – all with ...
(Date:4/25/2017)... ... April 25, 2017 , ... ... Newport Beach, California, committed to raising awareness for Duchenne muscular dystrophy, and ... its randomized CAP-1002 (cardiosphere-derived cells) Phase I/II HOPE clinical trial in Duchenne ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... NASHVILLE , Tenn. and DALLAS , ... and EndoStim, Inc., announced that the first patients in ... with the EndoStim device in the Lower Esophageal Sphincter ... is a minimally-invasive implantable device designed to provide long-term ... through neurostimulation. GERD affects nearly 65 million ...
(Date:4/19/2017)... 2017  New research provides evidence that an old drug ... a study released today that will be presented at the ... Boston , April 22 to 28, 2017. ... Parkinson,s disease, the oral drug levodopa has long been considered ... as the disease progresses, the effects of the medication can ...
(Date:4/18/2017)... -- Cogentix Medical, Inc. (NASDAQ: CGNT), a global medical ... Gynecology markets with innovative and proprietary products, will release ... 2017 after the market close on Tuesday, May 2, ... conference call and webcast to discuss its financial results ... 4:30 p.m. Eastern Time (3:30 p.m. Central Time). ...
Breaking Medicine Technology: