Navigation Links
Digestive acid production dependent on newly found hormone

A newly discovered hormone has been found to play an important role in the digestion of fat, cholesterol, and fat-soluble vitamins, such as vitamins A, E, and D. The hormone is found to control the production of bile acid by sending signals to the liver//.

The bile acids play a very important role in the emulsification of fats that enables absorption. The hormone is called fibroblast growth factor (FGF 15), the secretion of which depends on the level of bile acid secretion. FGF15 in turn limits further production of bile acid by the liver by negative feedback mechanism.

Bile acids are powerful detergents; the concentrations must be tightly regulated for proper functioning of the human body. The body needs enough quantity of the bile acid to absorb fat and other nutrients. However, too much can damage tissues and organs. This new mechanism probably holds the key to protect the body from the effects of over production of the bile acid.

Researchers have identified a receptor that senses bile acid and responds by secreting FGF15. In the liver, the secreted intestinal protein limits the activity of an enzyme called cholesterol 7a-hydroxylase (CYP7A1) critical to bile acid production. Animal models lacking FGF15 were found to have increased CYP7A1 activity and excrete greater quantities of bile acid.

The results of the present study have valuable clinical implications. For example, the above mentioned feedback mechanism might be an explanation to the liver damage associated with intravenous infusion of nutrients.

The findings also raise additional questions about the role that the circulating hormone may play in other parts of the body. An additional insight into cholesterol-derived bile acids might also yield important clues regarding cholesterol control. However, further studies in human beings are needed at the moment.
'"/>




Page: 1

Related medicine news :

1. Breast-fed Children Weather Digestive Disease
2. Obesity: Digestive Disorders Come In The Way Of Exercise
3. Silence Puts Comfort For Digestive Syndrome
4. Many Irish in the Grips of Digestive Disorders
5. Bioengineering production strains - Microbia develops new methods
6. Roche confirms Tamiflu production talks in US
7. Pigs have another utility: production of healthy oils!
8. WHO takes initiative to fight corruption tainted medicine production-supply chain
9. Adult bone health is dependent on lifestyle we live
10. Religious sensitivity of medicos gender-dependent
11. Time for Bono to Rock The Independent For AIDS Awareness
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/25/2017)... ... September 25, 2017 , ... Dr. Edward Hebert is celebrating ... imagine doing anything else,” said Dr. Hebert. “I count my blessings daily for the ... with my patients is what I look forward to the most. The relationships I ...
(Date:9/25/2017)... ... September 25, 2017 , ... “Grandpa's Visit”: a tender and ... share with the others. “Grandpa's Visit” is the creation of published author, Beverly Brumfield, ... is much like the character in her book. She shares, “Mr. Rice is struggling ...
(Date:9/25/2017)... ... , ... The trend-spotters, tastemakers, and healthy lifestyle product experts at the ... drinks, with the new NEXTY Gold Award at the Natural Products Expo East trade ... which is reserved for just those companies that hit high marks on the criteria ...
(Date:9/25/2017)... ... September 25, 2017 , ... Emerald Ash Borers kill Ash trees in as ... throughout the Philadelphia region. A video by Rob Nagy, ISA Certified Arborist at Giroud ... While several are dead or showing signs of decline from Emerald Ash Borers, two ...
(Date:9/24/2017)... ... ... Andrea Purcell, NMD, had an epiphany one evening. Four months pregnant, she sat sobbing at ... pregnancy was so hard. She wondered why no one talks about what it is really ... she decided to write what she wished her friends and colleagues could have told her: ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... NeuroRx, a clinical stage biopharma company developing the ... has been granted Fast Track status by the US Food ... HCl) followed by NRX-101 (D-cycloserine + lurasidone). The company will ... sequential therapy targeting patients who are admitted to Emergency Departments ... ...
(Date:9/5/2017)... , Sept. 5, 2017  Just 18 months after ... is pleased to announce the appointment of three new ... Wynne , Dominic Jones-Phillips and James ... Tammy Wynne ... of market access writers. She has over ten years, ...
(Date:8/31/2017)... , Aug. 31, 2017 PM360,s annual ... guide to the latest innovations happening across the industry. ... publication to focus on providing a comprehensive look at ... issue covers the most innovative companies, startups, divisions, products, ... "Everyone in this industry wants ...
Breaking Medicine Technology: