Navigation Links
Differences Between BP Medicines and Newly-Diagnosed Diabetes Identified

Researchers from Rush University have Identified Antihypertensive Drugs that Facilitate and/or Prevent Diabetes//.

Patients with high blood pressure are more likely to develop new-onset diabetes than those who don’t have hypertension, but this tendency is often attributed to higher weight, recent weight gain, or stronger family history of diabetes among those with high blood pressure.

Doctors have known since 1958 that some drugs used to control high blood pressure have the side effect of increasing blood sugar and causing new-onset diabetes.

Researchers at Rush University Medical Center analyzed the data from all of the randomized clinical trials (in which the assignment of initial drugs is based solely on chance, thus balancing the groups regarding other risk factors for diabetes), and have found significant differences between antihypertensive drugs. ACE-inhibitors and the newer angiotensin receptor blockers, or ARBs prevent people from getting diabetes, and the older diuretics or beta-blockers, increase the chance that a person becomes diabetic, compared to either placebo (inactive sugar-pills) or calcium channel blockers according to a study published in the January 20, 2007 issue of The Lancet.

Rush Preventive Medicine professor Dr. William J. Elliott, and Peter Meyer, Ph.D., director of the Section of Biostatistics, analyzed 22 long-term randomized clinical trials of each class of antihypertensive drugs, including placebo (inactive sugar-pills), to assess the chance that a person would develop diabetes during about 5 years of observation. The studies included 143,153 patients, and took place from 1966 through mid-September of 2006.

Their novel method of combining all the information available from clinical trials found that the lowest risk of new-onset diabetes occurred with ARBs or ACE-inhibitors, followed by calcium channel blockers or placebo (both of which were relatively neutral), and highest with beta -blockers or diuretics. They concluded that compared to inactive sugar-pills, diuretics or beta-blockers slightly increase the risk of becoming diabetic, whereas ARBs or ACE-inhibitors significantly decrease the risk.

“Most other studies of the association between drugs used mostly for high blood pressure could have been confused by differences in the patients studied. By only including studies that used randomization to minimize and balance differences between those assigned to different antihypertensive drugs, and by using a novel technique that can attribute risk both between agents that have been directly compared, and those that compare the results indirectly, we can see differences that other techniques cannot,” said Elliott.

“Our ‘indirect comparisons’ are similar to the way oddsmakers in Las Vegas compute the point spread for Sunday’s Bears-Saints playoff game. Since the Bears and Saints haven’t played each other (i.e., a direct comparison) this season, one can compare the record of the Bears against those teams that the Saints have also played this season. We use a similar strategy to compare, for example, ACE-inhibitors vs. ARBs, which have not been compared directly in any clinical trial to date.”

The study is expected to be of greater interest in the United Kingdom than the United States, because the British National Institute of Health and Clinical Excellence issued a new set of guidelines about hypertension treatment for primary care physicians in June 2006 that are based on economic considerations. Because diabetics generate about 4 times the healthcare expenditures as non-diabetics, the new British guidelines recommend against using both a diuretic and a beta-blocker for the routine treatment of hypertension. In the United States, however, tradition and the 2003 national hypertension guidelines still recommend a diuretic as first-line treatment, and a beta-blocker only one of several acceptable second-line options.

The authors were careful to point out that their data do not address the ongoing controversy about whether new-onset diabetes leads to as many heart attacks, strokes or death, as long-standing diabetes, which will require more studies.

The authors’ data do suggest, however, that the differences between antihypertensive drugs regarding the risk for new-onset diabetes are real and significant. Whether an overweight person with hypertension, others in the family with diabetes, and a recent weight gain can avoid the diagnosis of diabetes in the long-term by taking a specific type of antihypertensive drug is uncertain, and should be discussed with the treating physician as just one aspect of the choice of drug to lower blood pressure in that individual.

Source-Eurekalet
SRI
'"/>




Related medicine news :

1. Differences in brain pattern among liars and cheats in comparison to honest people
2. Functional Differences In Estrogen Receptor Could Be A Therapeutic Target
3. Ethnic Differences in Healthcare
4. Ethnic Variations in Hormone Levels May Cause Differences in Breast Cancer Risk
5. Wide Differences between NHS staff and ministers
6. Diminishing Differences and Empowering Eves
7. Biological Differences in Breast Cancer
8. Link Between Infection And Heart Disease
9. Prescription Drug Use Varies Widely Between States
10. Wait Between Pregnancies
11. Link Between Migraines and Behavioral Disorders
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... or dementia. However, many long-term care insurance companies have a waiver for care if ... the 90-day elimination period, when the family pays for care, is often waived, so ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for ... for action towards gender equality at their inaugural Summit in New York City in ... reached a social audience of over 3 million. To watch the Mobilize Women video, ...
(Date:10/13/2017)... ... 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, ... and least understood books in the Holy Scriptures, Revelation. The Book of Revelation paints ... for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins says ...
(Date:10/13/2017)... ... 13, 2017 , ... Coveros, a leader in agile coaching ... contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile ... of Agile methodologies in a consistent and high value manner across CMS programs. ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “America On The ... identity. “America On The Brink” is the creation of published author, William Nowers. ... great-grandchildren. As a WWII veteran, he spent thirty years in the Navy. ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Labs announces the European launch of their new low volume, high ... in Cambridge, U.K on October 4th. The ... with unprecedented speed and sensitivity while using far less sample volume ... ... ...
(Date:9/27/2017)... 2017  Commended for their devotion to personalized service, SMP ... number one in the South Florida Business Journal,s 50 Fastest-Growing ... yearly list, the national specialty pharmacy has found its niche.  ... will soon be honored by SFBJ as the 2017 Power ... Set to receive his award in October, Bardisa said of ...
(Date:9/23/2017)... Sept. 22, 2017 Janssen Biotech, Inc. (Janssen) ... letter from the U.S. Food and Drug Administration (FDA) ... sirukumab for the treatment of moderately to severely active ... clinical data are needed to further evaluate the safety ... active RA. ...
Breaking Medicine Technology: