Navigation Links
Dietary Vitamin B6, B12 and Folate, may Decrease Pancreatic Cancer Risk Among Leans

PHILADELPHIA − Researchers exploring the notion that certain nutrients might protect against pancreatic cancer found that lean individuals who got most of these nutrients from food were protected against developing cancer. The study also suggests this protective effect does not hold true if the nutrients come from vitamin supplements.

In a study published in the June 1 issue of Cancer Research, a journal of the American Association for Cancer Research, investigators combined data from four large studies and found that people who were at or below normal body weight decreased their risk for developing pancreatic cancer if they took in high levels of vitamin B6, vitamin B12, and folate from food.

The study determined that their risk was 81 percent, 73 percent, and 59 percent lower, vitamin B6, vitamin B12, and folate respectively, compared with participants who did not eat as much of these nutrients or who weighed more. According to the researchers, that was the only statistically significant finding from the study, which is the largest yet to look at these nutrients and pancreatic cancer risk.

All we can say is that a person who has reason to be concerned about their risk of developing this cancer, which is relatively rare but quite deadly, should maintain a normal weight and eat their fruit and vegetables, said the studys lead investigator, Eva Schernhammer, M.D., Dr.P.H., an assistant professor of medicine at Harvard Medical School.

The researchers also say that they uncovered another interesting trend − that some people who received these nutrients from multivitamin pills had an increased risk of developing the disease. According to the researchers, individuals who said they used multivitamins, and whose blood showed traces of these nutrients, had a 139 percent increased relative risk of developing pancreatic cancer.

This is a preliminary, but intriguing, finding because it suggests that something in the vitamins may fuel pancreatic cancer growth, Dr. Schernhammer said.

This isnt the first study to suggest that folate, and vitamin B6 and B12 − so called one carbon nutrients − are protective against pancreatic cancer if they come from food, but not if they come from multivitamins, Dr. Schernhammer said.

One large Finnish study found one carbon food nutrients were associated with a decreased risk of developing pancreatic cancer, but that vitamin pills were not helpful. Two other large American studies also found the food nutrients to be protective, but that vitamin use was associated with a higher, yet non-significant risk of developing the cancer.

In this study, researchers combined four large prospective cohort studies, The Womens Health Initiative, and three from the Harvard School of Public Health: the Nurses Health Study, the Health Professionals Follow-up Study, and the Physicians Health Study. From this large database, they performed a prospective nested case-control study to examine plasma concentrations of the nutrients from participants who had donated blood and answered questionnaires about their food intake and vitamin use before any cancer developed. Their analysis included 208 pancreatic cancer cases and 623 cancer-free control cases.

No one knows why vitamin pills may not help ward off cancer, or why, in this study, it might have a deleterious effect, Dr. Schernhammer said, but some research in animals suggests that if there is a dormant tumor, folate and other similar vitamins may stimulate growth. That might be especially true if a person did not take in enough of these nutrients consistently through diet, and then suddenly started taking multivitamins in an effort to become healthy, she said.

People think that dietary intake of these nutrients reflects a lifelong healthy eating habit, and in those cases, these nutrients may be protective, but they could have an opposite effect if they are used in a person with an occult cancer, Dr. Schernhammer said. It might all depend on whether a person is cancer-free at the time they start using these nutrients.

The same kind of association has been found with use of soy, which is an estrogen-rich food, she said. Women who have eaten soy all their lives, such as people in Asia, have a reduced risk of developing breast cancer, but some studies have found that increased soy intake in women who have not eaten it before appears to be harmful.

The researchers say their study cannot definitively say that one carbon nutrients either pose a benefit or a hazard to most people, but they note that it is the best analysis that can be performed outside of a randomized clinical trial.


'"/>




Related medicine news :

1. Dietary phytonutrients – Secret for the good food to taste ba
2. New Dietary Approach To Manage Kidney Stones
3. Dietary advice for diabetes
4. Dietary cure for fighting Helicobacter pylori
5. Dietary Changes Could Reduce The Risk for Stroke
6. Tackling Prostate Cancer With A New Dietary Supplement
7. Teenagers Using Hormones And Dietary Supplements To Good Physique
8. Dietary supplementation of Folic Acid Requires Critical Evaluation
9. Adding Sorghum Compounds To Dietary Supplements May Help Lower Cholesterol
10. Dietary pattern of Soy consumption among women at risk for breast cancer
11. Dietary intake of Vitamin E by type 2 diabetics for prevention of atherosclerosis
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/5/2016)... ... May 05, 2016 , ... Phycologia ... A (UV-A) for photosynthesis, researchers Juntian Xu and Kunshan Gao tested the magnitude ... pair observed that when photosynthetically active radiation (i.e. the white light in our ...
(Date:5/5/2016)... ... May 05, 2016 , ... Every ... the most heartfelt wishes of these children. The wishes provide hope and ... President and CEO of Make-A-Wish Mississippi, Brent Wilson said, “In 2016, the organization ...
(Date:5/5/2016)... ... , ... Long Island’s fastest growing comprehensive eye care provider, North Shore ... Van Valkenburg, MD as part of their ongoing effort to increase ophthalmic coverage in ... partner of North Shore Eye Care. , “We are extremely proud to welcome ...
(Date:5/5/2016)... ... , ... TIME for Kids and The ZAC Foundation – a national leader ... nearly 1 million children with important water safety messages before summer break begins. ... accidental death in children one to 6 years of age. TIME for Kids ...
(Date:5/5/2016)... ... May 05, 2016 , ... In honor of National Nurses Week ... all over the United States to thank a nurse who's made a difference in ... $5 to the American Red Cross of San Diego/Imperial Counties (up to $10,000) every ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... , May 4, 2016 ... addition of the  "Global Acute Myeloid Leukemia ...  report to their offering.       ... Acute Myeloid Leukemia Market and Competitive Landscape ... Myeloid Leukemia pipeline products, Acute Myeloid Leukemia ...
(Date:5/3/2016)... CITY, Mo. , May 3, 2016 /PRNewswire/ ... Kansas Medical Center,s Institute for Advancing Medical Innovation ... and commercialize new drugs, diagnostics and medical devices. ... provides BioNovus Innovations with rights to license, develop ... "This partnership represents ...
(Date:5/3/2016)... , May 3, 2016 ACME ... Whelan and Delaware County Councilman ... Nasal Spray in all ACME pharmacies across ... for Disease Control and Prevention (CDC), naloxone has saved 26,463 lives ... officers in Delaware County were authorized to ...
Breaking Medicine Technology: