Navigation Links
Dietary Vitamin B6, B12 and Folate, may Decrease Pancreatic Cancer Risk Among Leans

PHILADELPHIA − Researchers exploring the notion that certain nutrients might protect against pancreatic cancer found that lean individuals who got most of these nutrients from food were protected against developing cancer. The study also suggests this protective effect does not hold true if the nutrients come from vitamin supplements.

In a study published in the June 1 issue of Cancer Research, a journal of the American Association for Cancer Research, investigators combined data from four large studies and found that people who were at or below normal body weight decreased their risk for developing pancreatic cancer if they took in high levels of vitamin B6, vitamin B12, and folate from food.

The study determined that their risk was 81 percent, 73 percent, and 59 percent lower, vitamin B6, vitamin B12, and folate respectively, compared with participants who did not eat as much of these nutrients or who weighed more. According to the researchers, that was the only statistically significant finding from the study, which is the largest yet to look at these nutrients and pancreatic cancer risk.

All we can say is that a person who has reason to be concerned about their risk of developing this cancer, which is relatively rare but quite deadly, should maintain a normal weight and eat their fruit and vegetables, said the studys lead investigator, Eva Schernhammer, M.D., Dr.P.H., an assistant professor of medicine at Harvard Medical School.

The researchers also say that they uncovered another interesting trend − that some people who received these nutrients from multivitamin pills had an increased risk of developing the disease. According to the researchers, individuals who said they used multivitamins, and whose blood showed traces of these nutrients, had a 139 percent increased relative risk of developing pancreatic cancer.

This is a preliminary, but intriguing, finding because it suggests that something in the vitamins may fuel pancreatic cancer growth, Dr. Schernhammer said.

This isnt the first study to suggest that folate, and vitamin B6 and B12 − so called one carbon nutrients − are protective against pancreatic cancer if they come from food, but not if they come from multivitamins, Dr. Schernhammer said.

One large Finnish study found one carbon food nutrients were associated with a decreased risk of developing pancreatic cancer, but that vitamin pills were not helpful. Two other large American studies also found the food nutrients to be protective, but that vitamin use was associated with a higher, yet non-significant risk of developing the cancer.

In this study, researchers combined four large prospective cohort studies, The Womens Health Initiative, and three from the Harvard School of Public Health: the Nurses Health Study, the Health Professionals Follow-up Study, and the Physicians Health Study. From this large database, they performed a prospective nested case-control study to examine plasma concentrations of the nutrients from participants who had donated blood and answered questionnaires about their food intake and vitamin use before any cancer developed. Their analysis included 208 pancreatic cancer cases and 623 cancer-free control cases.

No one knows why vitamin pills may not help ward off cancer, or why, in this study, it might have a deleterious effect, Dr. Schernhammer said, but some research in animals suggests that if there is a dormant tumor, folate and other similar vitamins may stimulate growth. That might be especially true if a person did not take in enough of these nutrients consistently through diet, and then suddenly started taking multivitamins in an effort to become healthy, she said.

People think that dietary intake of these nutrients reflects a lifelong healthy eating habit, and in those cases, these nutrients may be protective, but they could have an opposite effect if they are used in a person with an occult cancer, Dr. Schernhammer said. It might all depend on whether a person is cancer-free at the time they start using these nutrients.

The same kind of association has been found with use of soy, which is an estrogen-rich food, she said. Women who have eaten soy all their lives, such as people in Asia, have a reduced risk of developing breast cancer, but some studies have found that increased soy intake in women who have not eaten it before appears to be harmful.

The researchers say their study cannot definitively say that one carbon nutrients either pose a benefit or a hazard to most people, but they note that it is the best analysis that can be performed outside of a randomized clinical trial.


'"/>




Related medicine news :

1. Dietary phytonutrients – Secret for the good food to taste ba
2. New Dietary Approach To Manage Kidney Stones
3. Dietary advice for diabetes
4. Dietary cure for fighting Helicobacter pylori
5. Dietary Changes Could Reduce The Risk for Stroke
6. Tackling Prostate Cancer With A New Dietary Supplement
7. Teenagers Using Hormones And Dietary Supplements To Good Physique
8. Dietary supplementation of Folic Acid Requires Critical Evaluation
9. Adding Sorghum Compounds To Dietary Supplements May Help Lower Cholesterol
10. Dietary pattern of Soy consumption among women at risk for breast cancer
11. Dietary intake of Vitamin E by type 2 diabetics for prevention of atherosclerosis
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2017)... ... May 26, 2017 , ... The Radiology Business Management ... on current legislative activity and the latest regulatory concerns impacting RBMA members. The ... 10, and will continue through Monday, Sept. 11, at the Ritz-Carlton, Tysons Corner ...
(Date:5/26/2017)... ... May 26, 2017 , ... via seating is ... back 24/7 task chair specifically designed for clinical areas. Genie Copper Mesh is ... partner with Cupron® to provide customers with a game changing chair that is ...
(Date:5/26/2017)... ... 2017 , ... Rob Lowe acts as host and helps educate and inform ... hiking in American. Viewers can reconnect with America as it explores some of the ... consumers have looked for an inventive new place for a family vacation, and have ...
(Date:5/26/2017)... ... ... of Eden”: retells the stories of three Bible figures in modern terms. “Just What ... trader, horse farmer, artist and a former GM journeyman. Born in 1953 in Portland, ... to Dayton, Ohio, where Penny graduated high school. At sixteen, she toured France to ...
(Date:5/24/2017)... ... 24, 2017 , ... Dr. Alan I. Benvenisty, MD is dual board certified ... is known for his distinguished expertise and experience in the diagnosis and treatment of ... in treating renovascular disease and aortic aneurysm . He is known for his ...
Breaking Medicine News(10 mins):
(Date:5/6/2017)... 5, 2017  May is Stroke Awareness Month and ... most important methods to prevent a stroke: monitor and ... Disease Control and Prevention, undetected and uncontrolled hypertension is ... the global leader in personal heart health technology, recently ... heart attack and stroke and is advancing a national ...
(Date:5/4/2017)... Fix Inc. (" Fortuna "), a private, clinical-stage biotech ... need for embryonic and fetal stem cells by using direct ... Fortuna announced today the launch of its Scientific ... PhD; Father Kevin FitzGerald , S.J., PhD; Col. (R) ... Giordano , PhD. "We are excited and honored ...
(Date:5/4/2017)... 2017 Clarius Mobile Health, a digital ... scanners this week at the American Congress of ... San Diego, CA from ... the perfect tool for clinicians to easily confirm ... evaluate pregnancy-related complications like ectopic pregnancy and placenta ...
Breaking Medicine Technology: